The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.
Childhood trauma history differentiates amygdala response to sad faces within MDD
Open accessAbstract
Objective Heightened amygdala reactivity to aversive stimuli in major depression is regarded as a core feature of the underlying physiology but individual differences in amygdala response may also arise secondary to persistent changes in limbic function during early neurodevelopment relative to stressors such as childhood trauma. We sought to determine whether heightened amygdala response is a core feature of depression or a general risk factor for psychopathology secondary to early life stress. Method Twenty unipolar depressed patients with and without a history of significant early life trauma and 16 healthy comparison subjects underwent functional MRI in a cross-sectional study comparing neural response to sad and neutral faces. Results We observed a robust positive correlation between physical abuse and right amygdala response. A much weaker relationship with other forms of abuse and neglect was also found, suggesting differences between abuse subtypes and amygdala response. Group differences in amygdala response suggest heightened reactivity was not characteristic of persons with depression in general but was true primarily in those with a significant history of abuse. Conclusion These findings suggest the relationship between childhood trauma and risk for depression is mediated by heightened amygdala response but varies by abuse type. Preliminary evidence for two distinct depression phenotypes based on trauma history was also supported, consistent with differential etiology.
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“In addition, some studies even suggested that the relation between ELS/CT and risk for adult depression is actually mediated by this preceding amygdala hyperactivity (448, 449).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [449]
Experimental — accuracy not yet measuredIn the citing paper
“Experiences of deprivation may be more likely to lead to blunted VS reactivity to reward than experiences of threat,112 while both types of ELA can produce a pattern of heightened amygdala reactivity to threat.63,86,94,95”
From Early life adversity and health-risk behaviors: Proposed psychological and neural mechanisms (2018) · cites this paper as [94]
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Metadata
- Authors
- Grant, M. M., Cannistraci, C., Hollon, S. D., Gore, J., & Shelton, R.
- Affiliations
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
- Corresponding author
- Grant, Merida M.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 45
- Issue
- 7
- Pages
- 886-895
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC3090525
- OpenAlex
- W1994014181
- Semantic Scholar
- 95aa569437b33717259beb8794575622516915bb
- Cited by
- 166
- References
- 63
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 7 · 2021: 15 · 2020: 9 · 2019: 13 · 2018: 16 · 2017: 11 · 2016: 16 · 2015: 19 · 2014: 12 · 2013: 14 · 2012: 8
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (1 UL1 RR024975, K01 MH073092, K02 MH01697, R01 MH60713)
- National Center for Research Resources
- National Institutes of Health
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- childhood trauma, major depressive disorder, amygdala reactivity, physical abuse, neglect, early life stress, depression subtypes, limbic system
- MeSH terms
- Adult, Affect, Amygdala, Attention, Child, Child Abuse, Cross-Sectional Studies, Major Depressive Disorder, Facial Expression, Female, Humans, Hydrocortisone, Image Processing, Computer-Assisted, Individuality, Magnetic Resonance Imaging, Male, Pattern Recognition, Visual, Reaction Time, Reference Values, Saliva, Young Adult
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