Cited by 166Child Abuse and TraumaStress Responses and CortisolAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.

Childhood trauma history differentiates amygdala response to sad faces within MDD

Open access

Grant, Merida M., Cannistraci, Christopher, Hollon, Steven D., Gore, John, Shelton, Richard·2011·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2010.12.004PMC PMC3090525

Open this paper in CoChat — free account

Abstract

Objective Heightened amygdala reactivity to aversive stimuli in major depression is regarded as a core feature of the underlying physiology but individual differences in amygdala response may also arise secondary to persistent changes in limbic function during early neurodevelopment relative to stressors such as childhood trauma. We sought to determine whether heightened amygdala response is a core feature of depression or a general risk factor for psychopathology secondary to early life stress. Method Twenty unipolar depressed patients with and without a history of significant early life trauma and 16 healthy comparison subjects underwent functional MRI in a cross-sectional study comparing neural response to sad and neutral faces. Results We observed a robust positive correlation between physical abuse and right amygdala response. A much weaker relationship with other forms of abuse and neglect was also found, suggesting differences between abuse subtypes and amygdala response. Group differences in amygdala response suggest heightened reactivity was not characteristic of persons with depression in general but was true primarily in those with a significant history of abuse. Conclusion These findings suggest the relationship between childhood trauma and risk for depression is mediated by heightened amygdala response but varies by abuse type. Preliminary evidence for two distinct depression phenotypes based on trauma history was also supported, consistent with differential etiology.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jpsychires.2010.12.004

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410 · cited 3×
“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript Rating Scale for Depression; HRSD-17) (Piotrowski, 1999; Hamilton, 1967).”
BackgroundMethod
The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · cited 1×
“Keywords childhood trauma; amygdala; stress sensitization; depression Major depressive disorder is a serious illness estimated to affect 13 to 14 million adults annually and approximately 16% of the U.S. population across the lifespan (Kessler et al., 2003).”
Background
Effects of noise letters upon the identification of a target letter in a nonsearch task
Eriksen, B. A., & Eriksen, C. W. (1974) · Perception & Psychophysics · doi:10.3758/bf03203267 · Cited by 7,230 · cited 1×
“Imaging Protocol Stimuli and Paradigm Participants performed a gender identification variant of the Eriksen flanker task of selective attention (Eriksen and Eriksen, 1974) using selected Ekman faces as stimuli (Ekman and Friesen, 1976).”
Method
Co-planar stereotaxic atlas of the human brain : 3-dimensional proportional system : an approach to cerebral imaging
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058
Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications
Clark, L. A., & Watson, D. (1991) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.100.3.316 · Cited by 4,601
Pictures of Facial Affect
Ekman, P. (1976) · Medical Entomology and Zoology · Cited by 4,345
Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia
Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391 · cited 1×
“…are also linked to amygdala response including sex, (Killgore and Yurgelun-Todd, 2001; Schneider et al., 2000) severity of illness, (Drevets, 2003) anxiety, (Phan et al., 2006; Etkin and Wager, 2007) adult onset trauma (Shin et al., 2005) and basal glucocorticoid activity (Drevets et al., 2002).”
Background
Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708 · cited 2×
“…during early neurodevelopment in rodent and nonhuman primates, such as early maternal separation and poor postnatal care, has been linked specifically with long-term changes in structure and function of the brain (Kaffman and Meaney, 2007; Meaney, 2001; Mirescu et al., 2004; Sanchez, 2006).”
Background
Adverse childhood experiences and the risk of depressive disorders in adulthood
Chapman, D. P., Whitfield, C. L., Felitti, V. J., Dube, S. R., Edwards, V. J., & Anda, R. F. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2003.12.013 · Cited by 2,267 · cited 1×
“Parallel findings in clinical populations suggest child abuse and neglect significantly increase risk for depression (Chapman et al., 2004; Putnam, 2003; Widom et al., 2007).”
Background

Show all 63 references

Sorted by citations

The effects of childhood maltreatment on brain structure, function and connectivity
Teicher, M. H., Samson, J. A., Anderson, C. M., & Ohashi, K. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.111 · Cited by 1,856
Annual research review: enduring neurobiological effects of childhood abuse and neglect
Teicher, M. H., & Samson, J. A. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12507 · Cited by 1,473
Childhood maltreatment and psychopathology: a case for ecophenotypic variants as clinically and neurobiologically distinct subtypes
Teicher, M. H., & Samson, J. A. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12070957 · Cited by 1,050
Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics
Heim, C., & Binder, E. B. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.10.032 · Cited by 986
“In general, it is assumed that lack of validity of retrospective self reports leads to underestimation of the actual occurrence rather than overestimation (Hardt and Rutter, 2004).”
Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging
Dannlowski, U., Stuhrmann, A., Beutelmann, V., Zwanzger, P., Lenzen, T., Grotegerd, D., Domschke, K., Hohoff, C., Ohrmann, P., Bauer, J., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.021 · Cited by 954
Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation
Agorastos, A., Pervanidou, P., Chrousos, G. P., & Baker, D. G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00118 · Cited by 385
“In addition, some studies even suggested that the relation between ELS/CT and risk for adult depression is actually mediated by this preceding amygdala hyperactivity (448, 449).”
Background
Sensitive periods of amygdala development: the role of maltreatment in preadolescence
Pechtel, P., Lyons-Ruth, K., Anderson, C. M., & Teicher, M. H. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.04.025 · Cited by 342
“Future studies will need to assess whether functional response shows a similar sensitive period given that amygdala hyperreactivity to emotional stimuli has been frequently reported in individuals with ELS (Dannlowski et al., 2012; Grant et al., 2011;McCrory et al., 2011; van Harmelen et al., 2012).”
Background
Gray matter abnormalities in childhood maltreatment: a voxel-wise meta-analysis
Lim, L., Radua, J., & Rubia, K. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13101427 · Cited by 336
“and adults (61) relative to healthy subjects, together with”
Background
The Impact of Childhood Maltreatment: A Review of Neurobiological and Genetic Factors
McCrory, E., De Brito, S. A., & Viding, E. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00048 · Cited by 329
Traumatic Childhood Events and Autism Spectrum Disorder
Kerns, C. M., Newschaffer, C. J., & Berkowitz, S. J. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2392-y · Cited by 312
“chopathology (Grant et al. 2011; Williams et al. 2006).”
The theory of latent vulnerability: reconceptualizing the link between childhood maltreatment and psychiatric disorder
McCrory, E. J., & Viding, E. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000115 · Cited by 295
Childhood maltreatment is associated with an automatic negative emotion processing bias in the amygdala
Dannlowski, U., Kugel, H., Huber, F., Stuhrmann, A., Redlich, R., Grotegerd, D., Dohm, K., Sehlmeyer, C., Konrad, C., Baune, B. T., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22112 · Cited by 249
“In line with this notion, it was demonstrated that childhood maltreatment is associated with increased amygdala responsiveness to sad faces in depressed patients (Grant et al., 2011), to fearful/angry faces in a large sample of healthy subjects (Dannlowski et al.”
Background
Overlapping and segregated resting‐state functional connectivity in patients with major depressive disorder with and without childhood neglect
Wang, L., Dai, Z., Peng, H., Tan, L., Ding, Y., He, Z., Zhang, Y., Xia, M., Li, Z., Li, W., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22241 · Cited by 236
Early life adversity and health-risk behaviors: Proposed psychological and neural mechanisms
Duffy, K. A., McLaughlin, K. A., & Green, P. A. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13928 · Cited by 237
Childhood maltreatment: altered network centrality of cingulate, precuneus, temporal pole and insula
Teicher, M. H., Anderson, C. M., Ohashi, K., & Polcari, A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.016 · Cited by 202
Child Maltreatment and Developmental Psychopathology: A Multilevel Perspective
Cicchetti, D., & Toth, S. L. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy311 · Cited by 193
Resilience and the brain: a key role for regulatory circuits linked to social stress and support
Holz, N. E., Tost, H., & Meyer-Lindenberg, A. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0551-9 · Cited by 162
Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health
Heim, C. M., Entringer, S., & Buss, C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.011 · Cited by 158
Amygdala Reactivity and Anterior Cingulate Habituation Predict Posttraumatic Stress Disorder Symptom Maintenance After Acute Civilian Trauma
Stevens, J. S., Kim, Y. J., Galatzer-Levy, I. R., Reddy, R., Ely, T. D., Nemeroff, C. B., Hudak, L. A., Jovanovic, T., Rothbaum, B. O., & Ressler, K. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.015 · Cited by 177
Long-term consequences of childhood maltreatment: altered amygdala functional connectivity
Jedd, K., Hunt, R. H., Cicchetti, D., Hunt, E., Cowell, R. A., Rogosch, F. A., Toth, S. L., & Thomas, K. M. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000954 · Cited by 149
“Some previously reported results have come from children or adolescents (e.g., De Bellis & Hooper, 2012; McCrory et al., 2011, 2013), some from patient groups (e.g., Grant et al., 2011), and some from samples that did not include control subjects matched on demographic variables such as SES.”
Result
PTSD and autism spectrum disorder: Co-morbidity, gaps in research, and potential shared mechanisms.
Haruvi-Lamdan, N., Horesh, D., & Golan, O. (2017) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000298 · Cited by 166
“These include alterations in the functional connectivity of the amygdala and prefrontal cortex (Grant, Cannistraci, Hollon, Gore, & Shelton, 2011; Mazefsky et al., 2013; Williams et al., 2006), as well as dysregulation of the Hypothalamic-Pituitary-Adernal (HPA) axis (Baumeister, Lightman, &…”
Background
Childhood adversities and depression in adulthood: Current findings and future directions.
Liu, R. T. (2017) · Clinical Psychology Science and Practice · doi:10.1111/cpsp.12190 · Cited by 160
“Collectively, these findings are generally consistent with the view espoused by several researchers that depression in individuals with a history of childhood adversities may be a distinct subtype of this disorder with its own unique etiology (Grant et al., 2011).”
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139
The social ecology of childhood and early life adversity
Lopez, M., Ruiz, M. O., Rovnaghi, C. R., Tam, G. K.-Y., Hiscox, J., Gotlib, I. H., Barr, D. A., Carrión, V. G., & Anand, K. J. S. (2021) · Pediatric Research · doi:10.1038/s41390-020-01264-x · Cited by 200
Early life stress and trauma: developmental neuroendocrine aspects of prolonged stress system dysregulation
Agorastos, A., Pervanidou, P., Chrousos, G. P., & Kolaitis, G. A. (2018) · HORMONES · doi:10.1007/s42000-018-0065-x · Cited by 139
Amygdala hyper-connectivity in a mouse model of unpredictable early life stress
Johnson, F. K., Delpech, J.-C., Thompson, G. J., Wei, L., Jin, H., Hermán, P., Hyder, F., & Kaffman, A. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0092-z · Cited by 123
The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis
Antoniou, G., Lambourg, E. J., Steele, J. D., & Colvin, L. (2023) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.03.008 · Cited by 133
Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder
Murrough, J. W., Collins, K. A., Fields, J., DeWilde, K. E., Phillips, M. L., Mathew, S. J., Wong, E., Tang, C. Y., Charney, D. S., & Iosifescu, D. V. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.10 · Cited by 109
Childhood adversity as a transdiagnostic risk factor for affective disorders in adulthood: A systematic review focusing on biopsychosocial moderating and mediating variables
Hoppen, T. H., & Chalder, T. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.08.002 · Cited by 110
Attentional biases and the persistence of sad mood in major depressive disorder.
Clasen, P. C., Wells, T. T., Ellis, A. J., & Beevers, C. G. (2013) · Journal of Abnormal Psychology · doi:10.1037/a0029211 · Cited by 93
Everyday emotional dynamics in major depression.
Nelson, J., Klumparendt, A., Doebler, P., & Ehring, T. W. (2018) · Emotion · doi:10.1037/emo0000541 · Cited by 88
The Resilient Emotional Brain: A Scoping Review of the Medial Prefrontal Cortex and Limbic Structure and Function in Resilient Adults With a History of Childhood Maltreatment
Moreno-López, L., Ioannidis, K., Askelund, A. D., Smith, A., Schueler, K., & van Harmelen, A. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.12.008 · Cited by 98
Facial expression recognition: A meta-analytic review of theoretical models and neuroimaging evidence
Xu, P., Peng, S., Luo, Y., & Gong, G. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.023 · Cited by 102
Negative childhood experiences alter a prefrontal‐insular‐motor cortical network in healthy adults: A preliminary multimodal rsfMRI‐fMRI‐MRS‐dMRI study
Duncan, N. W., Hayes, D. J., Wiebking, C., Tiret, B., Pietruska, K., Chen, D. Q., Rainville, P., Marjańska, M., Ayad, O., Doyon, J., et al. (2015) · Human Brain Mapping · doi:10.1002/hbm.22941 · Cited by 91
“For instance, brain imaging studies have correlated NCEs to changes in both task-related [Grant et al., 2011; Mueller et al., 2010; Thomaes et al., 2012] and intrinsic (or resting state) brain activity [Bluhm et al.”
Background
Early adverse experience and substance addiction: Dopamine, oxytocin, and glucocorticoid pathways
Kim, S., Kwok, S., Mayes, L. C., Potenza, M. N., Rutherford, H. J. V., & Strathearn, L. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13140 · Cited by 85
Gene–Environment Interactions and Intermediate Phenotypes: Early Trauma and Depression
Hornung, O. P., & Heim, C. C. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00014 · Cited by 85
“In several of the above studies, neurobiological changes clearly distinguished between depressed persons or suicide victims with and without ELS experiences, including HPA axis reactivity (54, 59), hippocampal volume (65), PFC volume (62), amygdala reactivity (69), and methylation pattern (74, 76), suggesting that the…”
Background
Psilocybin and MDMA for the treatment of trauma-related psychopathology
Bird, C., Modlin, N. L., & Rucker, J. (2021) · International Review of Psychiatry · doi:10.1080/09540261.2021.1919062 · Cited by 94
“Furthermore, there are a variety of factors that influence outcomes following traumatic experiences (Grant et al., 2011).”
Background
The neural correlates of Childhood Trauma Questionnaire scores in adults: A meta-analysis and review of functional magnetic resonance imaging studies
Heany, S. J., Groenewold, N. A., Uhlmann, A., Dalvie, S., Stein, D. J., & Brooks, S. J. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001717 · Cited by 87
Treatment for Patients With a Functional Neurological Disorder (Conversion Disorder): An Integrated Approach
O’Neal, M. A., & Baslet, G. C. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17040450 · Cited by 78
Early life trauma and directional brain connectivity within major depression
Grant, M. M., White, D. M., Hadley, J. A., Hutcheson, N. L., Shelton, R. C., Sreenivasan, K. R., & Deshpande, G. (2014) · Human Brain Mapping · doi:10.1002/hbm.22514 · Cited by 76
“An affective paradigm described previously in more detail in our prior work related to ELT and amygdala reactivity was performed [Grant et al., 2011].”
BackgroundMethodResultInfluentialSelf-citation
Systemic Trauma
Goldsmith, R. E., Martin, C. G., & Smith, C. P. (2014) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2014.871666 · Cited by 71
“In addition, many psychological problems other than PTSD are associated with trauma exposure (Grant et al., 2011; O’Brien & Sher, 2013; Subica et al., 2012).”
Background
Associations between childhood maltreatment and emotion processing biases in major depression: results from a dot-probe task
Günther, V., Dannlowski, U., Kersting, A., & Suslow, T. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0501-2 · Cited by 65
“Abbreviations BAI: Beck anxiety inventory; BDI-II: Beck depression inventory; CTQ: Childhood trauma questionnaire; EA: Emotional abuse; EN: Emotional neglect; HAMD: Hamilton depression scale; LTE-Q: List of threatening experiences questionnaire; M: Mean; MDD: Major depressive disorder; PA: Physical abuse; PN: Physical…”
BackgroundResultInfluential
The association between childhood trauma and facial emotion recognition in adults with bipolar disorder
Russo, M., Mahon, K., Shanahan, M. R., SOLON, C. A., Ramjas, E., Turpin, J., & Burdick, K. E. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.08.004 · Cited by 62
“Data suggest that abnormally increased amygdala activity is associated with a history of childhood maltreatment in response to sad faces in depressed patients (Grant et al., 2011) and to negative faces (i.”
Background
Social Judgement in Borderline Personality Disorder
Nicol, K., Pope, M., Sprengelmeyer, R., Young, A. W., & Hall, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073440 · Cited by 58
HISTORY OF CHILDHOOD ABUSE AND MOTHER-INFANT INTERACTION: A SYSTEMATIC REVIEW OF OBSERVATIONAL STUDIES
Vaillancourt, K., Pawlby, S. J., & Fearon, P. R. M. (2017) · Infant Mental Health Journal · doi:10.1002/imhj.21634 · Cited by 69
Childhood maltreatment and impact on clinical features of major depression in adults
Medeiros, G. C., Prueitt, W. L., Minhajuddin, A., Patel, S. S., Czysz, A. H., Furman, J. L., Mason, B. L., Rush, A. J., Jha, M. K., & Trivedi, M. H. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113412 · Cited by 61
Imaging studies of functional neurologic disorders
Aybek, S., & Vuilleumier, P. O. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-12-801772-2.00007-2 · Cited by 60
Influence of Early Life Stress on Intra- and Extra-Amygdaloid Causal Connectivity
Grant, M. M., Wood, K. H., Sreenivasan, K. R., Wheelock, M. D., White, D. M., Thomas, J., Knight, D. C., & Deshpande, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.28 · Cited by 56
Self-citation
HPA axis genetic variation, pubertal status, and sex interact to predict amygdala and hippocampus responses to negative emotional faces in school-age children
Pagliaccio, D., Luby, J. L., Bogdan, R., Arpana Agrawal, A., Gaffrey, M. S., Belden, A. C., Botteron, K. N., Harms, M. P., & Barch, D. M. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.01.017 · Cited by 59
“Stress exposure has been shown to predict elevated threat-related amygdala reactivity across development (Bogdan et al., 2012; Ganzel et al., 2013; Grant et al., 2011; Tottenham et al., 2011).”
Increased amygdala reactivity following early life stress: a potential resilience enhancer role
Yamamoto, T., Toki, S., Siegle, G. J., Takamura, M., Takaishi, Y., Yoshimura, S., Okada, G., Matsumoto, T., Nakao, T., Muranaka, H., et al. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1201-x · Cited by 55
“Each statistical threshold of fMRI data analysis was set on the basis of previous studies [10, 11, 48].”
BackgroundMethod
Mothers' amygdala response to positive or negative infant affect is modulated by personal relevance
Strathearn, L., & Kim, S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00176 · Cited by 59
“In contrast, post-natal depressive and anxiety symptoms [which may also be associated with childhood maltreatment (Grant et al., 2011; McCrory et al., 2011)] are related to a diminished amygdala response to faces (Moses-Kolko et al., 2010; Barrett et al., 2011).”
Background
Increased activation of the fear neurocircuitry in children exposed to violence
van Rooij, S. J. H., Smith, R. D., Stenson, A. F., Ely, T. D., Xinyi, Y., Tottenham, N., Stevens, J. S., & Jovanović, T. (2020) · Depression and Anxiety · doi:10.1002/da.22994 · Cited by 57
“Increased amygdala activation has been demonstrated in adults reporting childhood maltreatment (Dannlowski, 2013; Dannlowski, 2012; Grant, 2011; van Harmelen, 2013) as well as in maltreated or neglected children (Maheu, 2010; McCrory, 2013; Suzuki, 2014; Tottenham, 2011).”
Background
Retrospectively reported childhood physical abuse, systemic inflammation, and resting corticolimbic connectivity in midlife adults
Kraynak, T. E., Marsland, A. L., Hanson, J. L., & Gianaros, P. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.186 · Cited by 54
Behavioral Evidence for an Impairment of Affective Theory of Mind Capabilities in Chronic Depression
Mattern, M., Walter, H., Hentze, C., Schramm, E., Drost, S., Schoepf, D., Fangmeier, T., Normann, C., Zobel, I., & Schnell, K. (2015) · Psychopathology · doi:10.1159/000430450 · Cited by 54
Early Life Stress and Pediatric Posttraumatic Stress Disorder
Pervanidou, P., Makris, G., Chrousos, G. P., & Agorastos, A. (2020) · Brain Sciences · doi:10.3390/brainsci10030169 · Cited by 58
“It has also been suggested that amygdala hyperactivity as a result of ELS or childhood trauma may mediate the risk for depression later in adult life [78,79].”
Background
Childhood trauma and amygdala nuclei volumes in youth at risk for mental illness
Nogovitsyn, N., Addington, J., de Souza, R. M., Placsko, T. J., Stowkowy, J., Wang, J., Goldstein, B. I., Bray, S., Lebel, C. A., Taylor, V. H., et al. (2020) · Psychological Medicine · doi:10.1017/s0033291720003177 · Cited by 54
Childhood Maltreatment, Cortical and Amygdala Morphometry, Functional Connectivity, Laterality, and Psychopathology
Teicher, M. H., & Khan, A. (2019) · Child Maltreatment · doi:10.1177/1077559519870845 · Cited by 45
Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats
Holschneider, D. P., Guo, Y., Mayer, E. A., & Wang, Z. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.12.003 · Cited by 44
“…the prominent role the amygdala plays in mediating the effects of stress, including ELS (Brydges et al., 2013; Fan et al., 2014; Fonzo et al., 2013; Grant et al., 2011; Pechtel et al., 2014; Suzuki et al., 2014; Whittle et al., 2013; Yang et al., 2014), as well as our finding of a broader positive…”
BackgroundResult
Relationship of Trauma Symptoms to Amygdala‐Based Functional Brain Changes in Adolescents
Nooner, K. B., Mennes, M., Brown, S., Castellanos, F. X., Leventhal, B., Milham, M. P., & Colcombe, S. J. (2013) · Journal of Traumatic Stress · doi:10.1002/jts.21873 · Cited by 43
Impact of family history and depression on amygdala volume
Saleh, K., Carballedo, A., Lisiecka, D., Fagan, A. J., Connolly, G., Boyle, G., & Frodl, T. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.10.004 · Cited by 42
“A recent study found a strong correlation between physical abuse and right amygdala reactivity to sad faces in MDD patients, showing one way in which these types of interactions could be influential (Grant et al., 2011).”
Early adversity contributes to chronic stress induced depression-like behavior in adolescent male rhesus monkeys
Zhang, Z.-Y., Mao, Y., Feng, X., Zheng, N., Lü, L., Ma, Y., Qin, D., & Hu, X. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.040 · Cited by 44
CHILDHOOD MALTREATMENT PREDICTS REDUCED INHIBITION-RELATED ACTIVITY IN THE ROSTRAL ANTERIOR CINGULATE IN PTSD, BUT NOT TRAUMA-EXPOSED CONTROLS: Research Article: Childhood Maltreatment, Inhibition, and PTSD
Stevens, J. S., Ely, T. D., Sawamura, T., Guzman, D., Bradley, B., Ressler, K. J., & Jovanovic, T. (2016) · Depression and Anxiety · doi:10.1002/da.22506 · Cited by 40
Effects of Early Neglect Experience on Recognition and Processing of Facial Expressions: A Systematic Review
Doretto, V. F., & Scivoletto, S. (2018) · Brain Sciences · doi:10.3390/brainsci8010010 · Cited by 43
“Five studies employed specific methods to explore neurological aspects of perception of facial expressions [49,52,53,55,56] and three attentional aspects [50,51,57].”
BackgroundInfluential
Impact of childhood maltreatment and resilience on behavioral and neural patterns of inhibitory control during emotional distraction
Demers, L. A., Hunt, R. H., Cicchetti, D., Cohen‐Gilbert, J. E., Rogosch, F. A., Toth, S. L., & Thomas, K. M. (2021) · Development and Psychopathology · doi:10.1017/s0954579421000055 · Cited by 42
Childhood maltreatment and response to novel face stimuli presented during functional magnetic resonance imaging in adults
Edmiston, E. K., & Blackford, J. U. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.11.009 · Cited by 39
“When viewing sad faces, depressed adults with a history of childhood maltreatment demonstrate increased amygdala activation (Grant et al., 2011).”
Background
Dysregulated responses to emotions among abstinent heroin users: correlation with childhood neglect and addiction severity
Gerra, G., Somaini, L., Manfredini, M., Raggi, M. A., Saracino, M. A., Amore, M., Leonardi, C., Cortese, E., & Donnini, C. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.011 · Cited by 37
Hippocampal pattern separation of emotional information determining risk or resilience in individuals exposed to childhood trauma: Linking exposure to neurodevelopmental alterations and threat anticipation
Lecei, A., & van Winkel, R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.010 · Cited by 45
Effects of childhood adversity on the volumes of the amygdala subnuclei and hippocampal subfields in individuals with major depressive disorder
Aghamohammadi‐Sereshki, A., Coupland, N. J., Silverstone, P. H., Huang, Y., Hegadoren, K., Carter, R., Seres, P., & Malykhin, N. V. (2021) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.200034 · Cited by 37
Dissoziation: ein transdiagnostisches Phänomen
Wallis, H., Vogel, M., Junne, F., & Binneböse, M. (2023) · Die Psychotherapie · doi:10.1007/s00278-022-00641-7 · Cited by 37
“Bezüglich der Disposition für dissoziative Symptome zeigte sich überdies, dass Kindheitstraumata zu einer gestörten emotionalen Regulation und Veränderung der Aktivität der Amygdala führen können (Grant et al. 2011).”
Background
A Preliminary Study of the Influence of Age of Onset and Childhood Trauma on Cortical Thickness in Major Depressive Disorder
Jaworska, N., Macmaster, F., Gaxiola, I., Cortese, F., Goodyear, B., & Ramasubbu, R. (2014) · BioMed Research International · doi:10.1155/2014/410472 · Cited by 32
Patterns of Cortico-Limbic Activations During Visual Processing of Sad Faces in Depression Patients: A Coordinate-Based Meta-Analysis
Lai, C. (2013) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.12060143 · Cited by 35
Interpersonal early‐life trauma alters amygdala connectivity and sustained attention performance
Fortenbaugh, F. C., Corbo, V., Poole, V. N., McGlinchey, R. E., Milberg, W., Salat, D. H., Degutis, J. M., & Esterman, M. S. (2017) · Brain and Behavior · doi:10.1002/brb3.684 · Cited by 38
Moderation of prior exposure to trauma on the inverse relationship between callous-unemotional traits and amygdala responses to fearful expressions: an exploratory study
Meffert, H., Thornton, L. C., Tyler, P. M., Botkin, M. L., Erway, A. K., Kolli, V. B., Pope, K., White, S. F., & Blair, J. (2018) · Psychological Medicine · doi:10.1017/s0033291718000156 · Cited by 35
“Youth with mood and anxiety disorders were included given the high comorbidity with DBDs (e.g. Angold et al. 1999; Loeber et al. 2000; Greene et al. 2002; Nock et al. 2007).”
Gene x environment interactions in conduct disorder: Implications for future treatments
Holz, N. E., Zohsel, K., Laucht, M., Banaschewski, T., Hohmann, S., & Brandeis, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.017 · Cited by 35
Childhood Sexual Abuse and Brain Development: A Discussion of Associated Structural Changes and Negative Psychological Outcomes
Edwards, D. (2018) · Child Abuse Review · doi:10.1002/car.2514 · Cited by 43
Varying Cognitive Scars – Differential Associations Between Types of Childhood Maltreatment and Facial Emotion Processing
Iffland, B., & Neuner, F. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00732 · Cited by 33
Early Adversity and Emotion Processing From Faces: A Meta-analysis on Behavioral and Neurophysiological Responses
Saarinen, A. I. L., Keltikangas‐Järvinen, L., Jääskeläinen, E., Huhtaniska, S., Pudas, J., Tovar-Perdomo, S., Penttilä, M., Miettunen, J., & Lieslehto, J. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.01.002 · Cited by 40
Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task
Nagy, S. A., Kürtös, Z., Németh, N., Perlaki, G., Csernela, E., Lakner, F. E., Doczi, T. P., Czéh, B., & Simon, M. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100399 · Cited by 32
Aberrant function of frontoamygdala circuits in adolescents with previous verbal abuse experiences
Lee, S. W., Yoo, J. H., Kim, K. W., Lee, J.-S., Kim, D., Park, H., Choi, J., & Jeong, B. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.10.029 · Cited by 34
“Previous studies using subliminal emotional stimuli (Costafreda et al., 2008; Dannlowski et al., 2013) or indirectly presented stimuli during gender-matching (Grant et al., 2011) showed higher responses in the right amygdala.”
BackgroundResult
History of childhood maltreatment augments dorsolateral prefrontal processing of emotional valence in PTSD
Fonzo, G. A., Huemer, J., & Etkin, A. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.12.015 · Cited by 33
“Moreover, recent research suggests that different prefrontal regions modulate different aspects of bottom-up reactivity instantiated in the amygdala.”
Background
5-HTTLPR–environment interplay and its effects on neural reactivity in adolescents
Walsh, N., Dalgleish, T., Dunn, V. J., Abbott, R., Clair, M. S., Owens, M., Fairchild, G. F., Kerslake, W. S., Hiscox, L. V., Passamonti, L., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.07.067 · Cited by 32
Functional Correlates of childhood maltreatment and symptom severity during affective theory of mind tasks in chronic depression
Hentze, C., Walter, H., Schramm, E., Drost, S., Schoepf, D., Fangmeier, T., Mattern, M., Normann, C., Zobel, I., & Schnell, K. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.02.004 · Cited by 29
“…distinguishable from a stimulus driven automatic response to highly overlearned emotional cues such as facial expressions (Dannlowski et al., 2013; Grant et al., 2011; Klein et al., 2014; Siegle et al., 2002; Van Harmelen et al., 2013), as it has been suggested that CM inhibits early development…”
Background
Impact of early adverse life events and sex on functional brain networks in patients with urological chronic pelvic pain syndrome (UCPPS): A MAPP Research Network study
Gupta, A., Bhatt, R. R., Naliboff, B. D., Kutch, J. J., Labus, J. S., Vora, P. P., Alaverdyan, M., Schrepf, A., Lutgendorf, S. K., & Mayer, E. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217610 · Cited by 31
The beneficial effect of oxytocin on avoidance-related facial emotion recognition depends on early life stress experience
Feeser, M., Fan, Y., Weigand, A., Hahn, A., Gärtner, M., Aust, S., Böker, H., Bajbouj, M., & Grimm, S. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3631-1 · Cited by 29
Mediating processes between stress and problematic marijuana use
Ketcherside, A., & Filbey, F. M. (2015) · Addictive Behaviors · doi:10.1016/j.addbeh.2015.01.015 · Cited by 26
Childhood trauma is not a confounder of the overlap between autistic and schizotypal traits: A study in a non-clinical adult sample
Gong, J., Wang, Y., Lui, S. S. Y., Cheung, E. F. C., & Chan, R. C. K. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.07.035 · Cited by 27
“…showed alterations in the functional connectivity between the amygdala and the prefrontal cortex (Mazefsky and White, 2014), and such anomalies are also observed in individuals with history of chronic childhood adversity and other-related psychopathology (Grant et al., 2011; Williams et al., 2006).”
Heterogeneity of amygdala response in major depressive disorder: the impact of lifetime subthreshold mania
Fournier, J. C. J., Keener, M. T., Mullin, B. C., Hafeman, D., LaBarbara, E. J., Stiffler, R. S., Almeida, J., Kronhaus, D. M., Frank, E., & Phillips, M. L. (2012) · Psychological Medicine · doi:10.1017/s0033291712000918 · Cited by 27
“Indeed, a recent report by Grant et al. (2011) found that the association between depression and amygdala activity to sad facial displays was driven largely by the prior experience of childhood maltreatment.”
Background
Stress, psychiatric disorders, molecular targets, and more
Atrooz, F., Liu, H., & Salim, S. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.006 · Cited by 27
Stressful experiences in youth: “Set-up” for diminished resilience to chronic pain
Nelson, S., Burns, M. T. S., McEwen, B. S., & Borsook, D. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100095 · Cited by 26
The relationship between childhood trauma, emotion recognition, and irritability in schizophrenia patients
Bilgi, M. M., Taspinar, S., Özkul, B., Oğuz, K., Coburn, K. L., & Gönül, A. S. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.01.091 · Cited by 25
“, 2011), and apparently reflecting an underlying amygdala dysfunction (Grant et al., 2011; Marusak et al., 2015).”
Background
Hippocampal development in youth with a history of childhood maltreatment
Paquola, C., Bennett, M. R., Hatton, S. N., Hermens, D. F., Groote, I. R., & Lagopoulos, J. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.03.019 · Cited by 25
“Enhanced amygdala activation to emotional faces is consistently detected amongst individuals with a history CM (Bogdan et al., 2012; Grant et al., 2011; van Harmelen et al., 2013).”
Background
Early life stress and HPA axis function independently predict adult depressive symptoms in metropolitan Cebu, Philippines
Kim, A. W., Adam, E. K., Bechayda, S. A., & Kuzawa, C. W. (2020) · American Journal of Physical Anthropology · doi:10.1002/ajpa.24105 · Cited by 25
Neural correlates of three types of negative life events during angry face processing in adolescents
Gollier-Briant, F., Martinot, M. P., Lemaître, H., Miranda, R., Vulser, H., Goodman, R., Penttilä, J., Struve, M., Fadai, T., Kappel, V., et al. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw100 · Cited by 23
“regional response (Grant et al., 2011), supporting the need to investigate the type of NLE, but it is still unclear whether findings of atypical emotional processing may generalize to juveniles who have experienced other, more common, NLE.”
Background
Early life maltreatment but not lifetime depression predicts insecure attachment in women
Zietlow, A., Nonnenmacher, N., Reck, C., Mueller, M., Herpertz, S. C., Neukel, C., Fuchs, A., Bermpohl, F., Fuehrer, D., Kluczniok, D., et al. (2017) · Archives of Women s Mental Health · doi:10.1007/s00737-017-0731-z · Cited by 21
Decreased functional coupling within default mode network in major depressive disorder with childhood trauma
Wang, X., Liu, Q., Fan, J., Gao, F., Xia, J., Liu, X., Du, H., Liao, H., Tan, C., & Zhu, X. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.07.051 · Cited by 21
Altered Function of Ventrolateral Prefrontal Cortex in Adolescents with Peer Verbal Abuse History
Lee, S. W., Choi, J., Lee, J.-S., Yoo, J. H., Kim, K. W., Kim, D., Park, H., & Jeong, B. (2017) · Psychiatry Investigation · doi:10.4306/pi.2017.14.4.441 · Cited by 23
The role of sexual abuse on functional neuroimaging markers associated with major depressive disorder
Skokauskas, N., Carballedo, A., Fagan, A. J., & Frodl, T. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1048723 · Cited by 21
¿Influye el trauma infantil en el reconocimiento de las emociones faciales independientemente del diagnóstico de trastorno mental grave?
Catalán, A., Díaz, A., Angosto, V., Zamalloa, I., Martínez, N., Guede, D., Aguirregomoscorta, F., Bustamante, S. E. Z., Larrañaga, L., Osa, L., et al. (2018) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2018.10.003 · Cited by 21
The neurobiology of self-processing in abused depressed adolescents
Quevedo, K. M., Ng, R., Scott, H., Smyda, G. W., Pfeifer, J. H., & Malone, S. (2016) · Development and Psychopathology · doi:10.1017/s0954579416001024 · Cited by 20
Pregnancy-specific stress and sensitive caregiving during the transition to motherhood in adolescents
Scorza, P., Merz, E. C., Spann, M. N., Steinberg, E. J., Feng, T., Lee, S., Werner, E. A., Peterson, B. S., & Monk, C. E. (2021) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-021-03903-5 · Cited by 19

Authors: Grant, M. M., Cannistraci, C., Hollon, S. D., Gore, J., & Shelton, R.
Affiliations: Vanderbilt University (US)
Vanderbilt University Medical Center (US)
Corresponding author: Grant, Merida M.
ORCID: Grant, Merida M.
Hollon, Steven D.
Gore, John
Shelton, Richard
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2011-07
Volume: 45
Issue: 7
Pages: 886-895
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2010.12.004
PMC: PMC3090525
OpenAlex: W1994014181
Semantic Scholar: 95aa569437b33717259beb8794575622516915bb
Cited by: 166
References: 63
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 7 · 2021: 15 · 2020: 9 · 2019: 13 · 2018: 16 · 2017: 11 · 2016: 16 · 2015: 19 · 2014: 12 · 2013: 14 · 2012: 8
FWCI: 12.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (1 UL1 RR024975, K01 MH073092, K02 MH01697, R01 MH60713)
National Center for Research Resources
National Institutes of Health
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: childhood trauma, major depressive disorder, amygdala reactivity, physical abuse, neglect, early life stress, depression subtypes, limbic system
MeSH terms: Adult, Affect, Amygdala, Attention, Child, Child Abuse, Cross-Sectional Studies, Major Depressive Disorder, Facial Expression, Female, Humans, Hydrocortisone, Image Processing, Computer-Assisted, Individuality, Magnetic Resonance Imaging, Male, Pattern Recognition, Visual, Reaction Time, Reference Values, Saliva, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Childhood trauma history differentiates amygdala response to sad faces within MDD

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks