The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study
Open accessAbstract
The central nervous system has the second highest concentration of lipids after adipose tissue. Alterations in neural membrane phospho- and sphingolipid composition can influence crucial intra- and intercellular signalling and alter the membrane's properties. Recently, the polyunsaturated fatty acids (PUFA) hypothesis for depression suggests that phospho- and sphingolipid metabolism includes potential pathways for the disease. In 742 people from a Dutch family-based study, we assessed the relationships between 148 different plasma phospho- and sphingolipid species and depression/anxiety symptoms as measured by the Hospital Anxiety and Depression Scales (HADS-A and HADS-D) and the Centre for Epidemiological Studies Depression Scale (CES-D). We observed significant differences in plasma sphingomyelins (SPM), particularly the SPM 23:1/SPM 16:0 ratio, which was inversely correlated with depressive symptom scores. We observed a similar trend for plasma phosphatidylcholines (PC), particularly the molar proportion of PC O 36:4 and its ratio to ceramide CER 20:0. Absolute levels of PC O 36:4 were also associated with depression symptoms in an independent replication. To our knowledge this is the first study on depressive symptoms that focuses on specific phospho- and sphingolipid molecules in plasma rather than total PUFA concentrations. The findings of this lipidomic study suggests that plasma sphingomyelins and ether phospholipids should be further studied for their potential as biomarkers and for a better understanding of the underlying mechanisms of this systemic disease.
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“Several studies have indicated an association between the lipid concentrations of octadecyl-phosphatidylethanolamine (PE-O) [58], SM, and PC-O [63] and symptom severity according to the specific scales.”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [63]
Citations
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
The validity of the Hospital Anxiety and Depression Scale
Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00296-3 · Cited by 9,779 · cited 1×
“Several validation studies on various types of patients using different diagnostic tools have shown that HADS performs well in assessing symptom severity and case status for anxiety disorders and depression in both somatic, psychiatric and primary care patients and in the general population (Bjelland et al., 2002).”
MethodMultipoint Quantitative-Trait Linkage Analysis in General Pedigrees
Almasy, L. A., & Blangero, J. (1998) · The American Journal of Human Genetics · doi:10.1086/301844 · Cited by 3,021
Fisher, R. A. (1915) · Biometrika · doi:10.1093/biomet/10.4.507 · Cited by 2,230
Fisher, R. A. (1915) · Biometrika · doi:10.2307/2331838 · Cited by 1,334
Beekman, A. T. F., Deeg, D. J. H., van Limbeek, J., Braam, A. W., VRIES, M. Z. D., & van Tilburg, W. (1997) · Psychological Medicine · doi:10.1017/s0033291796003510 · Cited by 1,135
Brügger, B., Erben, G., Sandhoff, R., Wieland, F., & Lehmann, W. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2339 · Cited by 882
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00128-6 · Cited by 555
Handbook of clinical neurology
Munsat, T. L. (1993) · Neuromuscular Disorders · doi:10.1016/0960-8966(93)90014-b · Cited by 552
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Brain membrane lipids in major depression and anxiety disorders
Müller, C. P., Reichel, M., Mühle, C., Rhein, C., Gulbins, E., & Kornhuber, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.014 · Cited by 308
“amined persons with other types of disorders that also had depressive symptoms [46,83,144].”
BackgroundAntidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
Gulbins, A., Schumacher, F., Becker, K. A., Wilker, B., Soddemann, M., Boldrin, F., Müller, C. P., Edwards, M. J., Goodman, M. D., Caldwell, C. C., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0090-9 · Cited by 230
Analytical Methods in Lipidomics and Their Applications
Li, M., Li, Y., Bai, Y., & Liu, H. (2013) · Analytical Chemistry · doi:10.1021/ac403554h · Cited by 220
Gadad, B. S., Jha, M. K., Czysz, A., Furman, J. L., Mayes, T. L., Emslie, M. P., & Trivedi, M. H. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.001 · Cited by 205
“Most notably the ratio of sphingomyelin 23:1 to sphingomyelin 16:0 was inversely related to depression severity (Demirkan et al., 2013).”
BackgroundRegulation of sphingomyelin metabolism
Bienias, K., Fiedorowicz, A., Sadowska, A. J., Prokopiuk, S., & Car, H. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2015.12.008 · Cited by 199
Metadata
- Authors
- Demirkan, A., Isaacs, A., Ugocsai, P., Liebisch, G., Struchalin, M., Rudan, I., Wilson, J. F., Pramstaller, P. P., Gyllensten, U., Campbell, H., Schmitz, G., Oostra, B. A., & van Duijn, C. M.
- Affiliations
- Erasmus MC (NL)
- University Hospital Regensburg (DE)
- University of Split (HR)
- University of Edinburgh (GB)
- Eurac Research (IT)
- Uppsala University (SE)
- Corresponding author
- Isaacs, Aaron
- ORCID
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 47
- Issue
- 3
- Pages
- 357-362
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2164766370
- Cited by
- 163
- References
- 51
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 22 · 2023: 14 · 2022: 15 · 2021: 14 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 9 · 2016: 12 · 2015: 11 · 2014: 7 · 2013: 3
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- H2020 European Research Council
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- depression, anxiety, phospholipids, sphingolipids, ether phospholipids, polyunsaturated fatty acids, lipid biomarkers, family studies, ceramide
- MeSH terms
- Adult, Aged, Anxiety, Depression, Family Health, Female, Humans, Male, Middle Aged, Netherlands, Phosphatidylcholines, Psychiatric Status Rating Scales, Sphingomyelins
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