The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances in US Military Veterans
Open accessAbstract
Objective Pharmacological and cognitive-behavioral treatments targeting insomnia and nightmares have been shown to be effective in the treatment of military veterans with sleep complaints comorbid with symptoms of stress-related disorders, including Post-Traumatic Stress Disorder (PTSD), but the two approaches have not been directly compared. This randomized controlled trial compared the effects of prazosin vs. a behavioral sleep intervention (BSI), targeting nightmares and insomnia against a placebo pill control condition on sleep and daytime symptoms. Methods Fifty United States military veterans (mean age 40.9 years, SD = 13.2 years) with chronic sleep disturbances were randomized to prazosin (n = 18), BSI (n = 17), or placebo (n = 15). Each intervention lasted eight weeks. Participants completed self-report measures of insomnia severity, sleep quality, and sleep disturbances. All kept a sleep diary throughout the intervention period. Polysomnographic studies were conducted pre- and post-intervention. Results Both active treatment groups showed greater reductions in insomnia severity and daytime PTSD symptom severity. Sleep improvements were found in 61.9% of those who completed the active treatments and 25% of those randomized to placebo. Conclusion BSI and prazosin were both associated with significant sleep improvements and reductions in daytime PTSD symptoms in this sample of military veterans. Sleep-focused treatments may enhance the benefits of first-line PTSD treatments.
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Sleep disturbances as the hallmark of PTSD: where are we now?
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Psychiatric Disorders and Sleep
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Metadata
- Authors
- Germain, A., Richardson, R., Moul, D. E., Mammen, O., Haas, G., Forman, S. D., Rode, N., Begley, A., & Nofzinger, E. A.
- Venue
- Journal of Psychosomatic Research
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 72
- Issue
- 2
- Pages
- 89-96
- ISSN
- 0022-3999 (ISSN-L)
- OpenAlex
- W2060373473
- Cited by
- 229
- References
- 13
- FWCI
- 21.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Germain, A., Richardson, R., Moul, D. E., Mammen, O., Haas, G., Forman, S. D., Rode, N., Begley, A., & Nofzinger, E. A. (2012). Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances in US Military Veterans. Journal of Psychosomatic Research. https://doi.org/10.1016/j.jpsychores.2011.11.010
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