Gene Polymorphisms of Stress Hormone and Cytokine Receptors Associate with Immunomodulatory Profile and Psychological Measurement
Abstract
Objective We sought to identify whether stable single nucleotide polymorphisms (SNPs) of various endocrine and immune molecules could be used as biomarkers associated with specific immune alterations and chronic stress measures in normal humans.Methods A total of 207 volunteer participants answered stress questionnaire and gave peripheral blood cells for identification of SNPs in genes coding for glucocorticoid receptor (GR), beta 2 adrenergic receptor (B2AR), interferon-gamma receptors (IFNGR1, IFNGR2), and interleukin-4 receptor (IL4R). Immunoregulatory profiles were measured by flow cytometry and genotyping assays were performed by allelic discrimination real-time PCR.Results Several significant differences were revealed in associations between stress marker and immune indicators based on SNP categories. For instance, Th1 levels of the minor alleles of GR TthIIII (AA) and IFNGR2 Q64R (Arg/Arg) groups were positively associated with chronic stress (PSS) (p = 0.024 and 0.005, respectively) compared with wild type (WT) and negatively associated with PSS in the heterozygous genotypes of GR BclI and IL4R Ile50Val (p = 0.040 and p = 0.052, respectively). Treg levels of the minor alleles of BclI (GG) and IFNGR1 T-56C (CC) groups were positively associated with PSS (p = 0.045 and p = 0.010, respectively) and negatively associated in the minor allele (Val/Val) of IL4R Ile50Va and the heterozygous genotype of IL4R Q576R (p = 0.041 and p = 0.017, respectively) compared to WT.Conclusion The data support the notion that gene polymorphisms from various components of the psychoneuroendocrine-immune network may be useful as biomarkers to categorize individual stress-associated immune responses.
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There is a genetic predisposition to stress-induced immune dysregulation.
“This indicates a genetic predisposition to stress-induced immune dysregulation [13,27,62].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [62]
Chronic stress is linked with higher levels of Th1 cells in individuals carrying specific minor alleles of the glucocorticoid receptor and interferon-gamma receptor genes.
“The results showed that chronic stress is linked with higher levels of Th1 cells in individuals carrying specific minor alleles of the glucocorticoid receptor and interferon-gamma receptor genes.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [62]
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Shchaslyvyi, A. Y., Antonenko, S. V., & Telegeev, G. D. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21081077 · Cited by 73 · see citing works
- Authors
- Xiang, L., Rehm, K. E., Sunesara, I., Griswold, M., & Marshall, G. D.
- Affiliations
- University of Mississippi Medical Center (US)
- Corresponding author
- Xiang, Lianbin
- Venue
- Journal of Psychosomatic Research
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 78
- Issue
- 5
- Pages
- 438-444
- ISSN
- 0022-3999 (ISSN-L)
- OpenAlex
- W1986866712
- Cited by
- 6
- References
- 51
- Citations by year
- 2025: 1 · 2024: 3 · 2018: 1 · 2016: 1
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychosomatic Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- single nucleotide polymorphisms, glucocorticoid receptor, beta2-adrenergic receptor, interferon-gamma receptor, interleukin-4 receptor, chronic stress, Th1 cells, regulatory T cells, immunological markers, cytokine receptors
- MeSH terms
- Interferon gamma Receptor, Adult, Alleles, Chronic Disease, Female, Flow Cytometry, Genotype, Humans, Male, Receptors, Glucocorticoid, Stress, Psychological, Receptors, Interferon, Receptors, Cytokine, Receptors, Adrenergic, beta-2, Polymorphism, Single Nucleotide, Interleukin-4 Receptor alpha Subunit
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