The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Porous scaffolds for bone regeneration
Open accessAbstract
Globally, bone fractures due to osteoporosis occur every 20 s in people aged over 50 years. The significant healthcare costs required to manage this problem are further exacerbated by the long healing times experienced with current treatment practices. Novel treatment approaches such as tissue engineering, is using biomaterial scaffolds to stimulate and guide the regeneration of damaged tissue that cannot heal spontaneously. Scaffolds provide a three-dimensional network that mimics the extra cellular micro-environment supporting the viability, attachment, growth and migration of cells whilst maintaining the structure of the regenerated tissue in vivo. The osteogenic capability of the scaffold is influenced by the interconnections between the scaffold pores which facilitate cell distribution, integration with the host tissue and capillary ingrowth. Hence, the preparation of bone scaffolds with applicable pore size and interconnectivity is a significant issue in bone tissue engineering. To be effective however in vivo, the scaffold must also cope with the requirements for physiological mechanical loading. This review focuses on the relationship between the porosity and pore size of scaffolds and subsequent osteogenesis, vascularisation and scaffold degradation during bone regeneration.
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Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Bone Mechanical Properties in Healthy and Diseased States
Morgan, E. F., Unnikrisnan, G. U., & Hussein, A. I. (2018) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-062117-121139 · Cited by 1,026 · cited 1×
“variations in compressive strength and tensile values in different regions of bone [80].”
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Cited by
Bone Tissue Engineering Scaffolds: Function of Multi‐Material Hierarchically Structured Scaffolds
Koushik, T. M., Miller, C. M., & Antunes, E. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202766 · Cited by 359
Scaffold degradation in bone tissue engineering: An overview
Tajvar, S., Hadjizadeh, A., & Samandari, S. S. (2023) · International Biodeterioration & Biodegradation · doi:10.1016/j.ibiod.2023.105599 · Cited by 291
Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare
Jia, Z., Xu, X., Zhu, D., & Zheng, Y. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101072 · Cited by 176
Farjaminejad, S., Farjaminejad, R., Hasani, M., Garcia-Godoy, F., Abdouss, M., Marya, A., Harsoputranto, A., & Jamilian, A. (2024) · Polymers · doi:10.3390/polym16233303 · Cited by 158
Novel approaches and biomaterials for bone tissue engineering: a focus on silk fibroin
Paladini, F., & Pollini, M. (2022) · Materials · doi:10.3390/ma15196952 · Cited by 51
Metadata
- Authors
- Abbasi, N., Hamlet, S., Love, R. M., & Nguyen, N.-T.
- Venue
- Journal of Science: Advanced Materials and Devices
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 5
- Issue
- 1
- Pages
- 1-9
- ISSN
- 2468-2179 (ISSN-L)
- OpenAlex
- W3004519387
- Cited by
- 858
- References
- 2
- FWCI
- 30.37
- Type
- journal article
- Language
- en
- Open access
- gold
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- Abbasi, N., Hamlet, S., Love, R. M., & Nguyen, N.-T. (2020). Porous scaffolds for bone regeneration. Journal of Science: Advanced Materials and Devices. https://doi.org/10.1016/j.jsamd.2020.01.007
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