Novel approaches and biomaterials for bone tissue engineering: a focus on silk fibroin
Open accessAbstract
Bone tissue engineering (BTE) represents a multidisciplinary research field involving many aspects of biology, engineering, material science, clinical medicine and genetics to create biological substitutes to promote bone regeneration. The definition of the most appropriate biomaterials and structures for BTE is still a challenge for researchers, aiming at simultaneously combining different features such as tissue generation properties, biocompatibility, porosity and mechanical strength. In this scenario, among the biomaterials for BTE, silk fibroin represents a valuable option for the development of functional devices because of its unique biological properties and the multiple chances of processing. This review article aims at providing the reader with a general overview of the most recent progresses in bone tissue engineering in terms of approaches and materials with a special focus on silk fibroin and the related mechanisms involved in bone regeneration, and presenting interesting results obtained by different research groups, which assessed the great potential of this protein for bone tissue engineering.
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The β-sheet structure of silk fibroin contributes to network reinforcement and improved mechanical performance.
“Its β-sheet structure contributes to network reinforcement and improved mechanical performance [18].”
From Montmorillonite-reinforced methacrylated collagen/methacrylated silk fibroin hydrogel-based inks: rheological and physicochemical characterization for bone scaffold applications (2026) · cites this paper as [18]
Section 4 reports that increased fibroin crystallinity led to improved mechanical properties, and separately discusses β-sheet content in relation to degradation and osteogenic differentiation (page not provided). It does not say that β-sheets reinforce a network or directly attribute the mechanical improvement to β-sheet structure. (LLM, conf=0.83)
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- Authors
- Paladini, F., & Pollini, M.
- Affiliations
- University of Salento (IT)
- Corresponding author
- Paladini, Federica
- Pollini, Mauro
- Venue
- Materials
- Publisher
- MDPI AG
- Published
- 2022-10-07
- Volume
- 15
- Issue
- 19
- Pages
- 6952
- ISSN
- 1996-1944 (ISSN-L)
- PMC
- PMC9572978
- OpenAlex
- W4303856725
- Cited by
- 51
- References
- 132
- Citations by year
- 2026: 6 · 2025: 22 · 2024: 17 · 2023: 6
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- AIRUS (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- bone tissue engineering, silk fibroin, biomaterials, bone regeneration, biocompatibility, porosity, mechanical strength, protein scaffolds, bone substitutes
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