The DOI matches its Crossref record; 47 of the 49 references it cites were found in a registry or an index.
Opioid overdose prevention with intranasal naloxone among people who take methadone
Abstract
Overdose education and naloxone distribution (OEND) is an intervention that addresses overdose, but has not been studied among people who take methadone, a drug involved in increasing numbers of overdoses. This study describes the implementation of OEND among people taking methadone in the previous 30 days in various settings in Massachusetts. From 2008 to 2010, 1553 participants received OEND who had taken methadone in the past 30 days. Settings included inpatient detoxification (47%), HIV prevention programs (25%), methadone maintenance treatment programs (MMTP) (17%), and other settings (11%). Previous overdose, recent inpatient detoxification and incarceration, and polysubstance use were overdose risks factors common among all groups. Participants reported 92 overdose rescues. OEND programs are public health interventions that address overdose risk among people who take methadone and their social networks. OEND programs can be implemented in MMTPs, detoxification programs, and HIV prevention programs.
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“This route of administration has been validated for both OT (6, 71) and NAL (72–74) in previous human studies”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [73]
Citations
Cites
Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain
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Release from prison–a high risk of death for former inmates
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Loss of tolerance and overdose mortality after inpatient opiate detoxification: follow up study
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Saved by the nose: Bystander-administered intranasal naloxone hydrochloride for opioid overdose
Doe-Simkins, M., Walley, A. Y., Epstein, A., & Moyer, P. (2009) · American Journal of Public Health · doi:10.2105/ajph.2008.146647 · Cited by 250
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Einsatz von Take-Home Naloxon in Intoxikationssituationen
Essen, H. W.-V. (2022) · doi:10.20378/irb-54208
Patients with Substance Use Disorders and Dual Diagnoses
Brant, J. M., & Edwards, T. (2021) · doi:10.1093/med/9780197559321.003.0047
Message testing intentions to administer naloxone
Wygonik, Q. R., Glassman, T., Na, L., & Tucker‐Gail, K. (2024) · International Journal of Health Promotion and Education · doi:10.1080/14635240.2024.2438962
“Most opioid overdoses are witnessed by the victims’ family member or friend (Jones et al. 2017; Lankenau et al. 2013; Walley et al. 2013).”
Understanding the Opioid Overdose Crisis: A Comprehensive Bibliometric Analysis
Altherwi, T. I. (2025) · International Journal of Pharmacology · doi:10.31083/ijp44192
“Awareness of how frequently opioid overdose occurs enables timely action by focusing on particular interventions and preventative measures, such as naloxone distribution sites and supervised injection facilities [2,7–11].”
InfluentialBascou, N. A., Haslund-Gourley, B. S., Amber-Monta, K., Samson, K. R., Goss, N. C., Meredith, D. M., Friedman, A. V., Needleman, A., Kumar, V. K., & Fischer, B. D. (2022) · Figshare · doi:10.6084/m9.figshare.18517701
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Dennett, G., & Dennett, B. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6750622
Metadata
- Authors
- Walley, A. Y., Doe-Simkins, M., Quinn, E., Pierce, C., Xuan, Z., & Ozonoff, A.
- Affiliations
- Boston University (US)
- Boston Children's Hospital (US)
- Venue
- Journal of Substance Abuse Treatment
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 44
- Issue
- 2
- Pages
- 241-247
- ISSN
- 0740-5472 (ISSN-L)
- OpenAlex
- W1979851403
- Cited by
- 107
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 6 · 2017: 11 · 2016: 16 · 2015: 13 · 2014: 10 · 2013: 3
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Substance Abuse Treatment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention (1R21CE001602-02)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Keywords
- opioid overdose prevention, intranasal naloxone, overdose education and naloxone distribution, methadone maintenance treatment, opioid use disorder, overdose risk factors, inpatient detoxification, HIV prevention programs, polydrug use, prison history, public health interventions
- MeSH terms
- Administration, Intranasal, Adult, Female, Humans, Male, Massachusetts, Methadone, Middle Aged, Naloxone, Narcotic Antagonists, Opioid-Related Disorders, Narcotics, Patient Education as Topic, Pilot Projects, Risk Factors, Substance Withdrawal Syndrome, HIV Infections, Young Adult, Opiate Substitution Treatment, Drug Overdose
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