Cited by 250Opioid Use Disorder TreatmentSubstance Abuse Treatment and OutcomesHIV, Drug Use, Sexual Risk

Saved by the nose: Bystander-administered intranasal naloxone hydrochloride for opioid overdose

Open access
Doe-Simkins, Maya, Walley, Alexander Y., Epstein, Andy, Moyer, Peter·2009·American Journal of Public Health

Abstract

Administering naloxone hydrochloride (naloxone) during an opioid overdose reverses the overdose and can prevent death. Although typically delivered via intramuscular or intravenous injection, naloxone may be delivered via intranasal spray device. In August 2006, the Boston Public Health Commission passed a public health regulation that authorized an opioid overdose prevention program that included intranasal naloxone education and distribution of the spray to potential bystanders. Participants were taught by trained nonmedical needle exchange staff. After 15 months, the program provided training and intranasal naloxone to 385 participants who reported 74 successful overdose reversals. Problems with intranasal naloxone were uncommon. Overdose prevention education with distribution of intranasal naloxone is a feasible public health intervention to address opioid overdose.

Integrity signals

Registry

Crossref · 10.2105/ajph.2008.146647

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25 of 25 references verified0 citation errors · 0 not checkable

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Authors
Doe-Simkins, M., Walley, A. Y., Epstein, A., & Moyer, P.
Affiliations
Boston University (US)
Venue
American Journal of Public Health
Published
2009-05
Volume
99
Issue
5
Pages
788-791
ISSN
  • 0090-0036 (ISSN-L)
  • 1541-0048
OpenAlex
W2160243203
Cited by
250
References
25
Citations by year
2026: 5 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 19 · 2021: 20 · 2020: 13 · 2019: 17 · 2018: 20 · 2017: 19 · 2016: 25 · 2015: 22 · 2014: 22 · 2013: 14 · 2012: 9
FWCI
9.37
Type
journal article
Language
en
Open access
Locations
  • American Journal of Public Health (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
Keywords
intranasal naloxone, opioid overdose, overdose reversal, bystander intervention, public health regulation, harm reduction, opioid use disorder
MeSH terms
Administration, Intranasal, Adult, Emergency Medical Services, Female, Humans, Male, Naloxone, Narcotic Antagonists, Opioid-Related Disorders, Risk Factors, Program Evaluation, Needle-Exchange Programs, Drug Overdose

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