The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The beginning of a beautiful friendship: Cross-linking/mass spectrometry and modelling of proteins and multi-protein complexes
Open accessAbstract
After more than a decade of method development, cross-linking in combination with mass spectrometry and bioinformatics is finally coming of age. This technology now provides improved opportunities for modelling by mapping structural details of functional complexes in solution. The structure of proteins or protein complexes is ascertained by identifying amino acid pairs that are positioned in close proximity to each other. The validity of this technique has recently been benchmarked for large multi-protein complexes, by comparing cross-link data with that from a crystal structure of RNA polymerase II. Here, the specific nature of this cross-linking data will be discussed to assess the technical challenges and opportunities for model building. We believe that once remaining technological challenges of cross-linking/mass spectrometry have been addressed and cross-linking/mass spectrometry data has been incorporated into modelling algorithms it will quickly become an indispensable companion of protein and protein complex modelling and a corner-stone of integrated structural biology.
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Cited by
False discovery rate estimation for cross-linked peptides identified by mass spectrometry
Walzthoeni, T., Claassen, M., Leitner, A., Herzog, F., Bohn, S., Förster, F., Beck, M., & Aebersold, R. (2012) · Nature Methods · doi:10.1038/nmeth.2103 · Cited by 301
Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5
Komolov, K. E., Du, Y., Duc, N. M., Betz, R. M., Rodrigues, J. P. G. L. M., Leib, R. D., Patra, D., Skiniotis, G., Adams, C. M., Dror, R. O., et al. (2017) · Cell · doi:10.1016/j.cell.2017.03.047 · Cited by 152
Mass spectrometry supported determination of protein complex structure
Walzthoeni, T., Leitner, A., Stengel, F., & Aebersold, R. (2013) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2013.02.008 · Cited by 146
Ion Activation Methods for Peptides and Proteins
Macias, L. A., Santos, I. C., & Brodbelt, J. S. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04859 · Cited by 107
XL-MS: protein cross-linking coupled with mass spectrometry
Holding, A. N. (2015) · Methods · doi:10.1016/j.ymeth.2015.06.010 · Cited by 107
Metadata
- Authors
- Rappsilber, J.
- Venue
- Journal of Structural Biology
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 173
- Issue
- 3
- Pages
- 530-540
- ISSN
- 1047-8477 (ISSN-L)
- OpenAlex
- W1967086556
- Cited by
- 422
- References
- 7
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
