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Cited by 141Steroid Chemistry and BiochemistryEstrogen and related hormone effectsSexual Differentiation and Disorders

The DOI matches its Crossref record; 39 of the 41 references it cites were found in a registry or an index.

Enzymes involved in the formation and transformation of steroid hormones in the fetal and placental compartments

Pasqualini, J.R.·2005·The Journal of Steroid Biochemistry and Molecular Biology
DOI 10.1016/j.jsbmb.2005.08.004
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Abstract

Human fetal and placental compartments have all the enzymatic systems necessary to produce steroid hormones. However, their activities are different and complementary: the fetus is very active in converting acetate into cholesterol, in transforming pregnanes to androstanes, various hydroxylases, sulfotransferases, whilst all these transformations are absent or very limited in the placenta. This compartment can transform cholesterol to C21-steroids, convert 5-ene to 4-ene steroids, and has a high capacity to aromatize C19 precursors and to hydrolyse sulfates. Steroid hormone receptors are present at an early stage of gestation and are functional for important physiological activities. The production rate of some steroids increases drastically with fetal evolution (e.g. estriol increases 500-1000 times in relation to non-pregnant women). We can hypothesize that the control of active steroid hormones could be carried out by fetal and placental factors, which act by stimulating or inhibiting the enzymes involved in their formation and transformation during pregnancy evolution and, consequently, limiting the high levels of the biologically active hormone.

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Crossref · 10.1016/j.jsbmb.2005.08.004

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Research works printed but not linked: 1

  1. Guichard, 1975, Activité de la Δ5-3β hydroxystéroide deshydrogenase dans le placenta humain à terme après culture: influence de l’hormone gonadotrope chorionique, C.R. Acad. Sci. – Paris, 280, 1481

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Metadata

Authors
Pasqualini, J. R.
Corresponding author
Pasqualini, J.R.
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
2005-12
Volume
97
Issue
5
Pages
401-415
ISSN
0960-0760 (ISSN-L)
DOI
10.1016/j.jsbmb.2005.08.004
OpenAlex
W2063029948
Cited by
141
References
41
Citations by year
2026: 6 · 2025: 10 · 2024: 2 · 2023: 10 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 9 · 2013: 4 · 2012: 12
FWCI
0.88
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
steroidogenesis, fetal steroidogenesis, placental steroidogenesis, steroid hydroxylase, sulfotransferase, cholesterol biosynthesis, aromatization, steroid hormone receptors, estriol, pregnancy, enzyme regulation
MeSH terms
Androgens, Breast Neoplasms, Cholesterol, Estriol, Estrogens, Female, Fetus, Glucocorticoids, Humans, Mineralocorticoids, Models, Biological, Placenta, Pregnancy, Progestins, Progesterone, Gonadal Steroid Hormones

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