Cited by 141Steroid Chemistry and BiochemistryEstrogen and related hormone effectsSexual Differentiation and Disorders

The DOI matches its Crossref record; 39 of the 41 references it cites were found in a registry or an index.

Enzymes involved in the formation and transformation of steroid hormones in the fetal and placental compartments

Pasqualini, J.R.·2005·The Journal of Steroid Biochemistry and Molecular Biology

DOI 10.1016/j.jsbmb.2005.08.004

Open this paper in CoChat — free account

Abstract

Human fetal and placental compartments have all the enzymatic systems necessary to produce steroid hormones. However, their activities are different and complementary: the fetus is very active in converting acetate into cholesterol, in transforming pregnanes to androstanes, various hydroxylases, sulfotransferases, whilst all these transformations are absent or very limited in the placenta. This compartment can transform cholesterol to C21-steroids, convert 5-ene to 4-ene steroids, and has a high capacity to aromatize C19 precursors and to hydrolyse sulfates. Steroid hormone receptors are present at an early stage of gestation and are functional for important physiological activities. The production rate of some steroids increases drastically with fetal evolution (e.g. estriol increases 500-1000 times in relation to non-pregnant women). We can hypothesize that the control of active steroid hormones could be carried out by fetal and placental factors, which act by stimulating or inhibiting the enzymes involved in their formation and transformation during pregnancy evolution and, consequently, limiting the high levels of the biologically active hormone.

Integrity signals

Registry

Crossref · 10.1016/j.jsbmb.2005.08.004

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Carcinogenicity of catechol estrogens in Syrian hamsters
Liehr, J. G., Wan-Fen, F., Sirbasku, D. A., & Ari-Ulubelen, A. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90080-4 · Cited by 356
Tissue Distribution of Estrogen Receptors Alpha (ER- ) and Beta (ER- ) mRNA in the Midgestational Human Fetus
Brandenberger, A. W., Tee, M. K., Lee, J. Y., Chao, V. A., & Jaffe, R. B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4400 · Cited by 335
Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?
Zhu, B. T., & Conney, A. H. (1998) · PubMed · Cited by 282
The selective estrogen enzyme modulators in breast cancer: a review
Pasqualini, J. R. (2004) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2004.03.001 · Cited by 192
Self-citation
Profiling transcript levels for steroidogenic enzymes in fetal tissues
Pezzi, V., Mathis, J. M., Rainey, W. E., & Carr, B. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2003.07.006 · Cited by 156
Upregulation of Estradiol C16 -hydroxylation in Human Breast Tissue: a Potential Biomarker of Breast Cancer Risk
Osborne, M. P., Bradlow, H. L., Wong, G. Y., & TELANG, N. T. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.23.1917 · Cited by 149
Comparative properties of the catechol estrogens, I: Methylation by catechol-O-methyltransferase and binding to cytosol estrogen receptors
Merriam, G. R., MacLusky, N. J., Picard, M. K., & Naftolin, F. N. (1980) · Steroids · doi:10.1016/0039-128x(80)90062-8 · Cited by 111
Expression and Cellular Localization of Estrogen Receptors α and β in the Human Fetus1
Takeyama, J., Suzuki, T., Inoue, S., Kaneko, C., Nagura, H., Harada, N., & Sasano, H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7447 · Cited by 102
Late Gestation Increase in 11β-Hydroxysteroid Dehydrogenase 1 Expression in Human Fetal Membranes: A Novel Intrauterine Source of Cortisol
Alfaidy, N., Li, W., MacIntosh, T., Yang, K., & Challis, J. R. G. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021915 · Cited by 97
The effect of endogenous estradiol metabolites on the proliferation of human breast cancer cells
Lippert, C., Seeger, H., & Mueck, A. O. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02305-6 · Cited by 85

Flagged first, then by citations

Show all 41 references

2 of the 41 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Guichard, 1975, Activité de la Δ5-3β hydroxystéroide deshydrogenase dans le placenta humain à terme après culture: influence de l’hormone gonadotrope chorionique, C.R. Acad. Sci. – Paris, 280, 1481

Sorted by citations

Weight Gain During Pregnancy: Reexamining the Guidelines
Rasmussen, K. M., & Yaktine, A. L. (2009) · Cited by 4,052
Endocrine Factors Modulating Immune Responses in Pregnancy
Schumacher, A., Costa, S., & Zenclussen, A. C. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00196 · Cited by 220
Placental steroidogenesis in pregnant women with polycystic ovary syndrome
Maliqueo, M. A., Lara, H. E., Sánchez, F., Echiburú, B., Crisosto, N., & Sir‐Petermann, T. (2012) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2012.10.015 · Cited by 223
The Role of the Placenta in Fetal Exposure to Xenobiotics: Importance of Membrane Transporters and Human Models for Transfer Studies
Prouillac, C., & Lecoeur, S. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.033571 · Cited by 214
Basics of androgen synthesis and action
Elzenaty, R. N., du Toit, T., & Flück, C. E. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101665 · Cited by 218
Regulation and deregulation of cholesterol homeostasis: The liver as a metabolic “power station”
Trapani, L. (2012) · World Journal of Hepatology · doi:10.4254/wjh.v4.i6.184 · Cited by 178
Alternative (backdoor) androgen production and masculinization in the human fetus
O’Shaughnessy, P. J., Antignac, J. P., Le Bizec, B., Morvan, M.-L., Svechnikov, K., Söder, O., Savchuk, I., Monteiro, A., Soffientini, U., Johnston, Z. C., et al. (2019) · PLOS Biology · doi:10.1371/journal.pbio.3000002 · Cited by 177
Potential significance of physiological and pharmacological glucocorticoids in early pregnancy
Michael, A. E., & Papageorghiou, A. T. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn021 · Cited by 173
Sex hormone metabolism in lung development and maturation
Seaborn, T., Simard, M., Provost, P. R., Piedbœuf, B., & Tremblay, Y. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.09.001 · Cited by 152
Steroid hormones and pregnancy
Noyola-Martínez, N., Halhali, A., & Barrera, D. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1564742 · Cited by 150
Evolution of steroids during pregnancy: Maternal, placental and fetal synthesis
Morel, Y., Roucher, F., Plotton, I., Goursaud, C., Tardy, V., & Mallet, D. (2016) · Annales d'Endocrinologie · doi:10.1016/j.ando.2016.04.023 · Cited by 119
Fetal programming by maternal stress: Insights from a conflict perspective
Giudice, M. D. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.014 · Cited by 113
Steroid profiling in pregnancy: A focus on the human fetus
Hill, M., Pašková, A., Kančeva, R., Velíková, M., Kubátová, J., Kancheva, L., Adamcová, K., Mikešová, M., Žižka, Z., Koucký, M., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.03.008 · Cited by 101
The role of sulfated steroid hormones in reproductive processes
Geyer, J., Bakhaus, K., Bernhardt, R., Blaschka, C., Dezhkam, Y., Fietz, D., Grosser, G., Hartmann, K., Hartmann, M. F., Neunzig, J., et al. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.07.002 · Cited by 88
The Human Placenta Expresses CYP17 and Generates Androgens De Novo
Escobar, J. C., Patel, S. S., Beshay, V. E., Suzuki, T., & Carr, B. R. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2504 · Cited by 80
Potassium channels are involved in testosterone-induced vasorelaxation of human umbilical artery
Cairrão, E., Álvarez, E., Santos-Silva, A. J., & Verde, I. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0213-3 · Cited by 76
Obesity-Induced Down-Regulation of the Mitochondrial Translocator Protein (TSPO) Impairs Placental Steroid Production
Lassance, L., Haghiac, M., Minium, J., Catalano, P., & Hauguel-de Mouzon, S. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2792 · Cited by 73
Metabolic Pathfinding Using RPAIR Annotation
Faust, K., Croes, D., & van Helden, J. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.03.006 · Cited by 71
Perfluorooctane Sulfonate Concentrations in Amniotic Fluid, Biomarkers of Fetal Leydig Cell Function, and Cryptorchidism and Hypospadias in Danish Boys (1980–1996)
Toft, G. V., Jönsson, B., Bonde, J. P., Nørgaard‐Pedersen, B., HOUGAARD, D. M., Cohen, A. S., Lindh, C. H., Ivell, R., Anand‐Ivell, R., & Lindhard, M. S. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409288 · Cited by 64
Steroid hormones specifically modify the activity of organic anion transporting polypeptides
Koenen, A., Köck, K., Keiser, M., Siegmund, W., Kroemer, H. K., & Grube, M. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.08.017 · Cited by 62
Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures
Saal, F. S. V., VandeVoort, C. A., Taylor, J. A., Welshons, W. V., Toutain, P., & Hunt, P. A. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.01.007 · Cited by 63
Vascular mechanisms of testosterone: The non-genomic point of view
Lorigo, M., Mariana, M., Lemos, M. C., & Cairrão, E. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105496 · Cited by 61
Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy
O’Shaughnessy, P. J., Monteiro, A., Bhattacharya, S., Fraser, M., & Fowler, P. (2012) · Molecular Human Reproduction · doi:10.1093/molehr/gas059 · Cited by 58
Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells
Karahoda, R., Kallol, S., Groessl, M., Ontsouka, E. C., Anderle, P., Flück, C. E., Štaud, F., & Albrecht, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041704 · Cited by 56
Cholesterol: From Feeding to Gene Regulation
Martini, C., & Pallottini, V. (2007) · Genes & Nutrition · doi:10.1007/s12263-007-0049-y · Cited by 53
Fetoplacental vasculature as a model to study human cardiovascular endocrine disruption
Lorigo, M., & Cairrão, E. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101054 · Cited by 50
Dysregulation of 11beta-hydroxysteroid dehydrogenases: implications during pregnancy and beyond
Konstantakou, P., Mastorakos, G. P., Vrachnis, N., Tomlinson, J., & Valsamakis, G. (2016) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2016.1171308 · Cited by 49
Reproductive immunomodulatory functions of B cells in pregnancy
Dutta, S., Sengupta, P., & Haque, N. (2019) · International Reviews of Immunology · doi:10.1080/08830185.2019.1674299 · Cited by 46
A single amino acid residue, Ala 105, confers 16α-hydroxylase activity to human cytochrome P450 17α-hydroxylase/17,20 lyase
Swart, A. C., Storbeck, K., & Swart, P. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.014 · Cited by 44
Adrenal and thyroid function in the fetus and preterm infant
Chung, H. R. (2014) · Korean Journal of Pediatrics · doi:10.3345/kjp.2014.57.10.425 · Cited by 44
Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines
Monier, M., El‐Mekabaty, A., Abdel-Latif, D. A., Mert, B. D., & Elattar, K. M. (2019) · Steroids · doi:10.1016/j.steroids.2019.108548 · Cited by 40
Modulation of fetoplacental growth, development and reproductive function by endocrine disrupters
Basak, S., Varma, S., & Duttaroy, A. K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1215353 · Cited by 39
Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother–newborn pairs
Pedersen, M., Halldorsson, T. I., Mathiesen, L., Mose, T., Brouwer, A., Hedegaard, M. S., Loft, S. H., Kleinjans, J. C. S., Besselink, H. T., & Knudsen, L. E. (2010) · Environment International · doi:10.1016/j.envint.2010.02.002 · Cited by 39
Obesity during pregnancy affects sex steroid concentrations depending on fetal gender
Maliqueo, M. A., Cruz, G., Espina, C., Contreras, I., García, M. I., Echiburú, B., & Crisosto, N. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.159 · Cited by 36
Emerging roles for LXRs and LRH-1 in female reproduction
Mouzat, K., Baron, S., Marceau, G., Caira, F., Sapin, V., Volle, D. H., Lumbroso, S., & Lobaccaro, J. A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.009 · Cited by 40
Endocrine Activity of Extraembryonic Membranes Extends beyond Placental Amniotes
Albergotti, L. C., Hamlin, H. J., McCoy, M. W., & Guillette, L. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005452 · Cited by 35
PKG is involved in testosterone-induced vasorelaxation of human umbilical artery
Cairrão, E., Santos-Silva, A. J., & Verde, I. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.04.025 · Cited by 34
Long‐ and short‐term effects of androgens in human umbilical artery smooth muscle
Saldanha, P., Cairrão, E., Maia, C. J., & Verde, I. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12047 · Cited by 34
Alterations of adrenal steroidomic profiles in preterm infants at birth
Travers, S. A. A., Martinerie, L., Boileau, P., Lombès, M., & Pussard, E. (2017) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2016-312457 · Cited by 33
Revisiting the physiological role of androgens in women
Rosato, E., Sciarra, F., Anastasiadou, E., Lenzi, A., & Venneri, M. A. (2022) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2022.2144834 · Cited by 36
Environmental cadmium exposure during gestation impairs fetal brain and cognitive function of adult offspring via reducing placenta-derived E2 level
Liu, W., Zhu, H.-L., Xiong, Y.-W., Lv, J., Huang, Y., & Wang, H. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.135668 · Cited by 31
Association of Maternal-Neonatal Steroids With Early Pregnancy Endocrine Disrupting Chemicals and Pregnancy Outcomes
Banker, M. M., Puttabyatappa, M., O’Day, P., Goodrich, J. M., Kelley, A. S., Domino, S. E., Smith, Y. R., Dolinoy, D. C., Song, P. X. ‐., Auchus, R. J., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa909 · Cited by 29
Immunohistochemical analysis of steroid sulfatase in human tissues
Selcer, K. W., DiFrancesca, H. M., Chandra, A. B., & Li, P. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.12.105 · Cited by 30
Heterocyclic ring extension of androstenedione: Synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives
Mohareb, R. M., Abbas, N. S., & Abdelaziz, M. A. (2014) · Steroids · doi:10.1016/j.steroids.2014.04.011 · Cited by 29
Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology
Marcuzzi, A., Piscianz, E., Zweyer, M., Bortul, R., Loganes, C., Girardelli, M., Baj, G., Monasta, L., & Celeghini, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030365 · Cited by 27
Heterocyclic steroids: Synthetic routes and biological characteristics of steroidal fused bicyclic pyrimidines
Elattar, K. M., & El‐Mekabaty, A. (2020) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.4174 · Cited by 26
The effects of di-2-ethylhexyl phthalate on testicular ultrastructure and hormone-regulated gene expression in male rats
Qin, X., Ma, Q., Yuan, J., Xinnan, H., Tan, Q., Zhang, Z., Wang, L., & Xu, X. (2018) · Toxicology Research · doi:10.1039/c7tx00257b · Cited by 23
Identification of amniotic fluid metabolomic and placental transcriptomic changes associated with abnormal development of cloned pig fetuses
Ao, Z., Li, Z., Wang, X., Zhao, C., Gan, Y., Wu, X. F., Zeng, F., Shi, J., Gu, T., Hong, L., et al. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23102 · Cited by 23
Does steroid sulfatase deficiency influence postpartum psychosis risk?
Davies, W. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.03.001 · Cited by 22
Computational modeling and biological validation of novel non-steroidal ligands for the cholesterol recognition/interaction amino acid consensus (CRAC) motif of the mitochondrial translocator protein (TSPO)
Midzak, A. S., Akula, N., Rone, M. B., & Papadopoulos, V. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.03.023 · Cited by 20
Biosynthesis of estetrol in human pregnancy: Potential pathways
Stanczyk, F. Z., & Archer, D. F. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106359 · Cited by 24
Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Umbilical Cord Serum from Pregnant Women Living Near a Chemical Plant in Tianjin, China
Yu, D., Liu, X., Liu, X., Cao, W., Zhang, X., Tian, H., Wang, J., Xiong, N., Wen, S., Wu, Y., et al. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16122178 · Cited by 21
Progesterone levels in cesarean and normal delivered term placentas
Feinshtein, V., Ben‐Zvi, Z., Sheiner, E., Amash, A., Sheizaf, B., & Holcberg, G. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1125-x · Cited by 21
Composition and Components of Gestational Weight Gain: Physiology and Metabolism
Rasmussen, K. M., & Yaktine, A. L. (2009) · Cited by 20
Breast cancer and steroid metabolizing enzymes: The role of progestogens
Pasqualini, J. R. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.11.006 · Cited by 20
Self-citation
The in ovo conversion of oestrone to oestrone sulfate is rapid and subject to inhibition by Bisphenol A
Paitz, R. T., & Bowden, R. M. (2015) · Biology Letters · doi:10.1098/rsbl.2014.0946 · Cited by 20
Metabolomic Changes after Coffee Consumption: New Paths on the Block
Favari, C., Righetti, L., Tassotti, M., Gethings, L. A., Martini, D., Rosi, A., Antonini, M., Rubert, J., Manach, C., Dei, A., et al. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000875 · Cited by 20
Lack of Renal 11 Beta-Hydroxysteroid Dehydrogenase Type 2 at Birth, a Targeted Temporal Window for Neonatal Glucocorticoid Action in Human and Mice
Martinerie, L., Pussard, E., Méduri, G., Delezoide, A., Boileau, P., & Lombès, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031949 · Cited by 20
Towards an Understanding of the Evolution of the Chorioallantoic Placenta: Steroid Biosynthesis and Steroid Hormone Signaling in the Chorioallantoic Membrane of an Oviparous Reptile1
Cruze, L., Kohno, S., McCoy, M. W., & Guillette, L. J. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.112.101360 · Cited by 22
Comparative profiling of adrenal steroids in maternal and umbilical cord blood
Travers, S. A. A., Martinerie, L., Boileau, P., Xue, Q.-Y., Lombès, M., & Pussard, E. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.11.012 · Cited by 19
Structure–activity relationship (SAR) analysis of a family of steroids acutely controlling steroidogenesis
Midzak, A. S., Rammouz, G., & Papadopoulos, V. (2012) · Steroids · doi:10.1016/j.steroids.2012.08.019 · Cited by 17
Elucidating Potential Profibrotic Mechanisms of Emerging Biomarkers for Early Prognosis of Hepatic Fibrosis
Zehra, M., Curry, J. C., Pillai, S. S., Lakhani, H. V., Edwards, C. E., & Sodhi, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134737 · Cited by 17
Biochemical Screening for Fetal Trisomy 21: Pathophysiology of Maternal Serum Markers and Involvement of the Placenta
Guibourdenche, J., Leguy, M.-C., Pidoux, G., Hébert-Schuster, M., Laguillier, C., Anselem, O., Grangé, G., Bonnet-Serrano, F., & Tsatsaris, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087669 · Cited by 17
Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism
Koskivuori, J., Voutilainen, R., Storvik, M., Häkkinen, M. R., Uusitalo, L., Keski‐Nisula, L., Backman, K., Auriola, S. O. K., & Lehtonen, M. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106357 · Cited by 16
Molecular cloning and characterization of the mouse Na+ sulfate cotransporter gene (Slc13a4): structure and expression
Dawson, P. A., Pirlo, K. J., Steane, S. E., Kunzelmann, K., Chien, Y. J., & Markovich, D. (2006) · Genes & Genetic Systems · doi:10.1266/ggs.81.265 · Cited by 16
Plasma steroid hormone concentrations and their relationships in Suffolk ewes during gestation and parturition
Miura, H., Yamazaki, T., KIKUCHI, M., & Sakaguchi, M. (2019) · Animal Science Journal · doi:10.1111/asj.13286 · Cited by 16
Maternal and Fetal Pharmacokinetics of Oral Radiolabeled and Authentic Bisphenol A in the Rhesus Monkey
VandeVoort, C. A., Gerona, R. R. L., Saal, F. S. V., Tarantal, A. F., Hunt, P. A., Hillenweck, A., & Zalko, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165410 · Cited by 16
Sex Differences in Pulmonary Anatomy and Physiology
Sathish, V., & Prakash, Y. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802388-4.00006-9 · Cited by 15
Altered umbilical sex steroids in preterm infants born small for gestational age
Allvin, K., Ankarberg‐Lindgren, C., Niklasson, A., Jacobsson, B., & Dahlgren, J. (2019) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2019.1598362 · Cited by 15
Pathophysiological Implications of Interstitial Cajal-like Cells (ICC-like) in Uterus: A Comparative Study with Gastrointestinal ICCs
López‐Pingarrón, L., Almeida, H., Pereboom, D., & García, J. J. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45090476 · Cited by 14
Hydroxylation and sulfation of sex steroid hormones in inflammatory liver
Sang, R., Seung-yeon, L., Sang-yun, K., Ryu, S., Bae-kuen, P., & Hong, E. (2017) · Journal of Biomedical Research · doi:10.7555/jbr.31.20170031 · Cited by 14
Evidence of steroid hormone activity in the chorioallantoic membrane of a Turtle (Pseudemys nelsoni)
Cruze, L., Hamlin, H. J., Kohno, S., McCoy, M. W., & Guillette, L. J. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.02.007 · Cited by 13
Maternal first trimester serum levels of free-beta human chorionic gonadotrophin and male genital anomalies
Schneuer, F. J., Bower, C. I., Holland, A. J. A., Tasevski, V., Jamieson, S., Barker, A., Lee, L., Majzoub, J. A., & Nassar, N. (2016) · Human Reproduction · doi:10.1093/humrep/dew150 · Cited by 13
Prenatal exposure to glycol ethers and sex steroid hormones at birth
Warembourg, C., Binter, A.-C., Giton, F., Fiet, J., Labat, L., Monfort, C., Chevrier, C., Multigner, L., Cordier, S., & Garlantézec, R. (2018) · Environment International · doi:10.1016/j.envint.2018.01.013 · Cited by 12
Protease Inhibitor Anti-HIV, Lopinavir, Impairs Placental Endocrine Function
Fraichard, C., Bonnet-Serrano, F., Laguillier, C., Hébert-Schuster, M., Lai–Kuen, R., Sibiude, J., Fournier, T., Cohen, M., & Guibourdenche, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020683 · Cited by 12
Atrazine disrupts gonadal development in a live-bearing lizard
Parsley, L. M., Wapstra, E., & Jones, S. (2015) · Endocrine Disruptors · doi:10.1080/23273747.2015.1006071 · Cited by 12
Expression of steroidogenic proteins in bovine placenta during the first half of gestation
Verduzco, A. R., Fecteau, G., Lefebvre, R. C., Smith, L. C., & Murphy, B. D. (2011) · Reproduction Fertility and Development · doi:10.1071/rd10303 · Cited by 11
Hormones, grossesse et relation materno-fætale
Gailly-Fabre, E., Kerlan, V., & Christin‐Maître, S. (2015) · Annales d Endocrinologie · doi:10.1016/s0003-4266(16)30006-3 · Cited by 11
Progestins in the menopause in healthy women and breast cancer patients
Pasqualini, J. R. (2009) · Maturitas · doi:10.1016/j.maturitas.2008.12.008 · Cited by 11
Self-citation
Role of the Sodium-Dependent Organic Anion Transporter (SOAT/SLC10A6) in Physiology and Pathophysiology
Wannowius, M., Karakuş, E., Aktürk, Z., Breuer, J., & Geyer, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129926 · Cited by 10
Placental production of progestins is fully effective in villous cytotrophoblasts and increases with the syncytiotrophoblast formation
Fraichard, C., Bonnet-Serrano, F., Garnier, A., Hébert-Schuster, M., Bouzerara, A., Gerbaud, P., Ferecatu, I., Fournier, T., Hernandez, I., Trabado, S., et al. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110586 · Cited by 10
Turning the spotlight on the C11-oxy androgens in human fetal development
du Toit, T., & Swart, A. C. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105946 · Cited by 11
Gestational cadmium exposure disrupts fetal liver development via repressing estrogen biosynthesis in placental trophoblasts
Fu, Y., Zhang, J., Liu, W., Zhang, Y., Zhang, S., Tan, L., Lin, Q., Ouyang, K.-W., Xiong, Y.-W., Chang, W., et al. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113807 · Cited by 9
Viviparity in Reptiles
Albergotti, L. C., & Guillette, L. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374930-7.10009-3 · Cited by 9
Maternal metabolomics linking prenatal exposure to fine particulate matter and birth weight: a cross-sectional analysis of the MADRES cohort
Chen, W., Qiu, C., Hao, J., Liao, J., Lurmann, F. W., Pavlovic, N., Habre, R., Jones, D. P., Bastain, T. M., Breton, C. V., et al. (2025) · Environmental Health · doi:10.1186/s12940-025-01162-x · Cited by 8
The Measurement of Estrogens
Holder, G., Makin, H. L. J., & Bradlow, H. L. (2010) · Springer eBooks · doi:10.1023/b135931_8 · Cited by 8
Bilirubin Reduces the Uptake of Estrogen Precursors and the Followed Synthesis of Estradiol in Human Placental Syncytiotrophoblasts via Inhibition and Downregulation of Organic Anion Transporter 4
Zhang, Y., Chen, Y., Dai, B., Bai, M., Lu, S., Lin, N., Zhou, H., & Jiang, H. (2022) · Drug Metabolism and Disposition · doi:10.1124/dmd.121.000685 · Cited by 7
Prenatal Exposure to Synthetic Phenols Assessed in Multiple Urine Samples and Dysregulation of Steroid Hormone Homeostasis in Two European Cohorts
Jedynak, P., Bustamante, M., Rolland, M., Mustieles, V., Thomsen, C., Sakhi, A. K., Sabaredzovic, A., Foraster, M., Gascón, M., Gómez‐Roig, M. D., et al. (2025) · Environmental Health Perspectives · doi:10.1289/ehp15117 · Cited by 6
Lethal Hypoplasia and Developmental Anomalies of the Lungs in a Newborn with Intrauterine Adrenal Hemorrhage and Cerebral Infarcts: A Proposed Pulmonary Disruption Sequence
Lertsburapa, T., Vargas, D., Lambert-Messerlian, G. M., Tantravahi, U., Gündoğan, F., de la Monte, S. M., Coyle, M. G., & Paepe, M. E. D. (2014) · Pediatric and Developmental Pathology · doi:10.2350/14-05-1485-cr.1 · Cited by 6
Maternal exercise alters rat fetoplacental stress response: Minimal effects of maternal growth restriction and high-fat feeding
Mangwiro, Y. T. M., Cuffe, J. S. M., Vickers, M. H., Reynolds, C. M., Mahizir, D., Anevska, K., Gravina, S., Romano, T., Moritz, K. M., Briffa, J. F., et al. (2020) · Placenta · doi:10.1016/j.placenta.2020.11.006 · Cited by 6
Lavender Essential Oil Modulates Hepatic Cholesterol Metabolism in HepG2 Cells
Martella, N., Colardo, M., Sergio, W., Petraroia, M., Varone, M., Pensabene, D., Russo, M., Bartolomeo, S. D., Ranalli, G., Saviano, G., et al. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45010026 · Cited by 7
Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate
Liu, J., Kandel, S. E., Lampe, J. N., & Scott, E. E. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104993 · Cited by 6
Understanding the Intersection of Environmental Pollution, Pneumonia, and Inflammation: Does Gender Play a Role?
Silveyra, P., Fuentes, N., & Rivera, L. (2017) · InTech eBooks · doi:10.5772/intechopen.69627 · Cited by 6
Placental RTN3L‐dependent ER‐Phagy Contributes to Fetal Testicular Dysplasia Upon Environmental Stress
Luo, Y., Zhu, H., Huang, B., Sun, C., Zhang, X., Wang, X., Hu, Y., Zhang, X., Xu, S., Zhou, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202500924 · Cited by 5
Risk Factors in Fetal Ovarian Cysts for Postnatal Adverse Outcomes
Muto, M., YOSHIZATO, T., Horinouchi, T., Yokomine, M., Sakamoto, Y., Ishii, S., Kinoshita, M., Kozuma, Y., & Ushijima, K. (2022) · The Kurume Medical Journal · doi:10.2739/kurumemedj.ms6934002 · Cited by 5
Expression of steroidogenic enzymes and steroid receptors in foetal gonads of domestic cat—Sex similarities and differences
Braun, B., & Jewgenow, K. (2016) · Reproduction in Domestic Animals · doi:10.1111/rda.12829 · Cited by 5
Placental Steroid Hormones in Preeclampsia: Multilayered Regulation of Endocrine Pathogenesis
Yang, Y. S., Zhang, S., Fang, X., Shao, T., Shao, X., & Wang, Y. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf039 · Cited by 4
A Review on Electrochemical and Optical Nanobiosensor for the Detection of Progesterone and Estradiol
Komal, Duhan, J., Dhuva, B., & Obrai, S. (2026) · ChemistrySelect · doi:10.1002/slct.202506371 · Cited by 4
In utero exposure to the oestrogen mimic diethylstilbestrol disrupts gonadal development in a viviparous reptile
Parsley, L. M., Wapstra, E., & Jones, S. (2014) · Reproduction Fertility and Development · doi:10.1071/rd13411 · Cited by 4
Placental and embryonic tissues exhibit aromatase activity in the viviparous lizard Niveoscincus metallicus
Parsley, L. M., Wapstra, E., & Jones, S. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.02.020 · Cited by 4

Authors: Pasqualini, J. R.
Corresponding author: Pasqualini, J.R.
Venue: The Journal of Steroid Biochemistry and Molecular Biology
Publisher: Elsevier BV
Published: 2005-12
Volume: 97
Issue: 5
Pages: 401-415
ISSN: 0960-0760 (ISSN-L)
DOI: 10.1016/j.jsbmb.2005.08.004
OpenAlex: W2063029948
Cited by: 141
References: 41
Citations by year: 2026: 6 · 2025: 10 · 2024: 2 · 2023: 10 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 9 · 2013: 4 · 2012: 12
FWCI: 0.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: steroidogenesis, fetal steroidogenesis, placental steroidogenesis, steroid hydroxylase, sulfotransferase, cholesterol biosynthesis, aromatization, steroid hormone receptors, estriol, pregnancy, enzyme regulation
MeSH terms: Androgens, Breast Neoplasms, Cholesterol, Estriol, Estrogens, Female, Fetus, Glucocorticoids, Humans, Mineralocorticoids, Models, Biological, Placenta, Pregnancy, Progestins, Progesterone, Gonadal Steroid Hormones

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Enzymes involved in the formation and transformation of steroid hormones in the fetal and placental compartments

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks