The DOI matches its Crossref record; 39 of the 41 references it cites were found in a registry or an index.
Enzymes involved in the formation and transformation of steroid hormones in the fetal and placental compartments
Abstract
Human fetal and placental compartments have all the enzymatic systems necessary to produce steroid hormones. However, their activities are different and complementary: the fetus is very active in converting acetate into cholesterol, in transforming pregnanes to androstanes, various hydroxylases, sulfotransferases, whilst all these transformations are absent or very limited in the placenta. This compartment can transform cholesterol to C21-steroids, convert 5-ene to 4-ene steroids, and has a high capacity to aromatize C19 precursors and to hydrolyse sulfates. Steroid hormone receptors are present at an early stage of gestation and are functional for important physiological activities. The production rate of some steroids increases drastically with fetal evolution (e.g. estriol increases 500-1000 times in relation to non-pregnant women). We can hypothesize that the control of active steroid hormones could be carried out by fetal and placental factors, which act by stimulating or inhibiting the enzymes involved in their formation and transformation during pregnancy evolution and, consequently, limiting the high levels of the biologically active hormone.
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“It is likely, therefore, that most progesterone in the fetal circulation comes from the placenta, which secretes progesterone directly into the fetal circulation at high levels [31,32], similar to those reported here.”
From Alternative (backdoor) androgen production and masculinization in the human fetus (2019) · cites this paper as [32]
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Self-citationProfiling transcript levels for steroidogenic enzymes in fetal tissues
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Endocrine Factors Modulating Immune Responses in Pregnancy
Schumacher, A., Costa, S., & Zenclussen, A. C. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00196 · Cited by 220
Placental steroidogenesis in pregnant women with polycystic ovary syndrome
Maliqueo, M. A., Lara, H. E., Sánchez, F., Echiburú, B., Crisosto, N., & Sir‐Petermann, T. (2012) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2012.10.015 · Cited by 223
Prouillac, C., & Lecoeur, S. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.033571 · Cited by 214
Basics of androgen synthesis and action
Elzenaty, R. N., du Toit, T., & Flück, C. E. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101665 · Cited by 218
Metadata
- Authors
- Pasqualini, J. R.
- Corresponding author
- Pasqualini, J.R.
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 97
- Issue
- 5
- Pages
- 401-415
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2063029948
- Cited by
- 141
- References
- 41
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 2 · 2023: 10 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 9 · 2013: 4 · 2012: 12
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- steroidogenesis, fetal steroidogenesis, placental steroidogenesis, steroid hydroxylase, sulfotransferase, cholesterol biosynthesis, aromatization, steroid hormone receptors, estriol, pregnancy, enzyme regulation
- MeSH terms
- Androgens, Breast Neoplasms, Cholesterol, Estriol, Estrogens, Female, Fetus, Glucocorticoids, Humans, Mineralocorticoids, Models, Biological, Placenta, Pregnancy, Progestins, Progesterone, Gonadal Steroid Hormones
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