Inter-conversion of 7α- and 7β-hydroxy-dehydroepiandrosterone by the human 11β-hydroxysteroid dehydrogenase type 1
Abstract
The dehydroepiandrosterone (DHEA) 7alpha-hydroxylation in humans takes place in the liver, skin, and brain. These organs are targets for the glucocorticoid hormones where 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activates cortisone through its reduction into cortisol. The putative interference of 7alpha-hydroxy-DHEA with the 11beta-HSD1-catalyzed reduction of cortisone into cortisol has been confirmed in preliminary works with human liver tissue preparations of the enzyme demonstrating the transformation of 7alpha-hydroxy-DHEA into 7-oxo-DHEA and 7beta-hydroxy-DHEA. However, the large production of 7beta-hydroxy-DHEA could not be explained satisfactorily. Therefore our objective was to study the role in the metabolism of oxygenated DHEA by recombinant human 11beta-HSD1 expressed in yeast. The 7alpha- and 7beta-hydroxy-DHEA were each oxidized into 7-oxo-DHEA with quite dissimilar K(M) (70 and 9.5 microM, respectively) but at equivalent V(max). In contrast, the 11beta-HSD1-mediated reduction of 7-oxo-DHEA led to the production of both 7alpha- and 7beta-hydroxy-DHEA with equivalent K(M) (1.1 microM) but with a 7beta-hydroxy-DHEA production characterized by a significantly greater V(max). The 7alpha-hydroxy-DHEA produced by the cytochrome CYP7B1 in tissues may exert anti-glucocorticoid effects through interference with the 11beta-HSD1-mediated cortisone reduction.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HSD11B2 only oxidizes the 7α-hydroxy-stereoisomer.
“while HSD11B2 only oxidizes the 7α-hydroxy-stereoisomer [110,111].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [111]
HSD11B1 functions as an epimerase interconverting the 7α- and 7β-hydroxy-stereoisomers via a 7-keto-intermediate.
“HSD11B1 functions as an epimerase interconverting the 7α- and 7β-hydroxy-stereoisomers via a 7-keto-intermediate”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [111]
HSD11B1 catalyses the interconversion of 7α- and 7β-OH-DHEA via the 7-keto intermediate.
“It catalyses the interconversion of 7α- and 7β-OH-DHEA via the 7-keto intermediate (Muller et al., 2006).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Muller et al., 2006
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Improved method for high efficiency transformation of intact yeast cells.
Gietz, D., Jean, A. S., Woods, R. A., & Schiestl, R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.6.1425 · Cited by 3,379 · see citing works
Seckl, J. R., & Walker, B. R. (2001) · Endocrinology · doi:10.1210/endo.142.4.8114 · Cited by 714 · see citing works
[6] Yeast expression of animal and plant P450s in optimized redox environments
Pompon, D., Louërat-Oriou, B., Bronine, A., & Urban, P. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)72008-6 · Cited by 654 · see citing works
Self-citationThe Measurement of Pyridine Nucleotides by Enzymatic Cycling
Lowry, O. H., Passonneau, J. V., Schulz, D. W., & Rock, M. K. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61729-1 · Cited by 494 · see citing works
Tannin, G. M., Agarwal, A. K., Monder, C., New, M. I., & White, P. C. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55351-5 · Cited by 436 · see citing works
Rose, K. A., Stapleton, G., Dott, K., Kiény, M. P., Best, R., Schwarz, M., Russell, D. W., Björkhem, I., Seckl, J. R., & Lathe, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.4925 · Cited by 221 · see citing works
Atanasov, A. G., Nashev, L. G., Schweizer, R. A. S., Frick, C., & Odermatt, A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.065 · Cited by 210 · see citing works
Seckl, J. R. (2001) · Endocrinology · doi:10.1210/en.142.4.1371 · Cited by 172 · see citing works
Bánhegyi, G., Benedetti, A., Fulceri, R., & Senesi, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404159200 · Cited by 169 · see citing works
Bujalska, I. J., Draper, N., Michailidou, Z., Tomlinson, J. W., White, P. C., Chapman, K. E., Walker, E. A., & Stewart, P. M. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01718 · Cited by 165 · see citing works
Rapid Hepatic Metabolism of 7-Ketocholesterol by 11β-Hydroxysteroid Dehydrogenase Type 1
Schweizer, R. A. S., Zürcher, M., Balázs, Z., Dick, B., & Odermatt, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313615200 · Cited by 131 · see citing works
Structure and functions of human oxysterol 7α-hydroxylase cDNAs and gene CYP7B1
Wu, Z. L., Martin, K. O., Javitt, N. B., & Chiang, J. Y. L. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32094-0 · Cited by 127 · see citing works
Steroid and sterol 7-hydroxylation: ancient pathways.
Lathe, R. (2002) · Steroids · doi:10.1016/s0039-128x(02)00044-2 · Cited by 104 · see citing works
Neurosteroid 7-hydroxylation products in the brain
Morfin, R. F., & Stárka, L. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)46059-4 · Cited by 99 · see citing works
Self-citationWeill‐Engerer, S., David, J.-P., Sazdovitch, V., Lière, P., Schumacher, M., Delacourte, A., Baulieu, É.-É., & Akwa, Y. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02288-1 · Cited by 91 · see citing works
Pringle, A. K., Schmidt, W., Deans, J. K., Wülfert, E., Reymann, K. G., & Sundström, L. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02734.x · Cited by 76 · see citing works
Hult, G. T. M., Elleby, B., Shafqat, N., Svensson, S., Rane, A., J�rnvall, H., Abrahmsén, L., & Oppermann, U. C. T. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3476-y · Cited by 74 · see citing works
Robinzon, B., Michael, K. K., Ripp, S. L., Winters, S. J., & Prough, R. A. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00056-0 · Cited by 70 · see citing works
Hult, M., JÖRNVALL, H., & Oppermann, U. C. T. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01515-4 · Cited by 60 · see citing works
Dulos, J., van der Vleuten, M. A. J., Kavelaars, A., Heijnen, C. J., & Boots, A. M. H. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20950 · Cited by 58 · see citing works
Khalil, M. W., Strutt, B. J., Vachon, D., & KILLINGER, D. W. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90186-z · Cited by 49 · see citing works
Involvement of steroids and cytochromes P450 species in the triggering of immune defenses
Morfin, R. F. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00025-0 · Cited by 49 · see citing works
Self-citationCooper, M. S., Syddall, H. E., Fall, C. H. D., Wood, P. J., Stewart, P. M., Cooper, C., & Dennison, E. M. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02281.x · Cited by 48 · see citing works
Immunoassay of 7-hydroxysteroids: 2. Radioimmunoassay of 7α-hydroxy-dehydroepiandrosterone
Lapčı́k, O., Hampl, R., Hill, M., & Stárka, L. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00145-4 · Cited by 46 · see citing works
Dudás, B., Hanin, I., Rose, M., & Wülfert, E. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.11.001 · Cited by 42 · see citing works
The human cytochrome P4507B1: catalytic activity studies
Kim, S.-B., Chalbot, S., Pompon, D., Jo, D.-H., & Morfin, R. F. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.09.005 · Cited by 41 · see citing works
Self-citationImmunoassay of 7-hydroxysteroids: 1. Radioimmunoassay of 7β-hydroxy dehydroepiandrosterone
Lapčı́k, O., Hampl, R., Hill, M., Bičı́ková, M., & Stárka, L. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00136-8 · Cited by 40 · see citing works
Purification and Characterization of Hamster Liver Microsomal 7α-Hydroxycholesterol Dehydrogenase
Song, W., Chen, J., Dean, W. L., Redinger, R. N., & Prough, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16223 · Cited by 39 · see citing works
Dulos, J., Verbraak, E., Bagchus, W. M., Boots, A. M. H., & Kaptein, A. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20509 · Cited by 39 · see citing works
Urban, P., Truan, G., Gautier, J., & Pompon, D. (1993) · Biochemical Society Transactions · doi:10.1042/bst0211028 · Cited by 35 · see citing works
Self-citationBlum, A., Martin, H.-J., & Maser, E. (2000) · Toxicology · doi:10.1016/s0300-483x(99)00197-3 · Cited by 30 · see citing works
Muller, C., Cluzeaud, F., Pinon, G. M., Rafestin-Oblin, M. E., & Morfin, R. F. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.10.014 · Cited by 30 · see citing works
Self-citationPregnenolone-7β-hydroxylating activity of human cytochrome P450-1A1
Doostzadeh, J., Flinois, J.-P., Beaune, P. H., & Morfin, R. F. (1997) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(96)00169-0 · Cited by 27 · see citing works
Self-citation7-Hydroxydehydroepiandrosterone epimers in human serum and saliva
Hill, M., Lapčı́k, O., Havlı́ková, H., Morfin, R. F., & Hampl, R. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)01106-2 · Cited by 24 · see citing works
Self-citationChalbot, S., Trap, C., Monin, J.-P., & Morfin, R. F. (2002) · Steroids · doi:10.1016/s0039-128x(02)00072-7 · Cited by 19 · see citing works
Self-citationŠulcová, J., Hill, M., Mašek, Z., Češka, R., Nováček, A., Hampl, R., & Stárka, L. (2001) · Physiological Research · doi:10.33549/physiolres.930039 · Cited by 18 · see citing works
Robinzon, B., Miller, K. K. M., & Prough, R. A. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.06.003 · Cited by 9 · see citing works
Hartmann, F., & Illner, W. R. (1973) · Research in Experimental Medicine · doi:10.1007/bf01855109 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
11β-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action
Chapman, K., Holmes, M., & Seckl, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00020.2012 · Cited by 887 · see citing works
Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works
Intracrine androgen biosynthesis, metabolism and action revisited
Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217 · see citing works
“It catalyses the interconversion of 7a- and 7b-OH-DHEA via the 7-keto intermediate (Muller et al., 2006).”
Dehydroepiandrosterone as a regulator of immune cell function
Hazeldine, J., Arlt, W., & Lord, J. M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.016 · Cited by 173 · see citing works
Mechanisms of Glucocorticoid Action During Development
Busada, J. T., & Cidlowski, J. A. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.12.004 · Cited by 141 · see citing works
Baker, M. E., Nelson, D. R., & Studer, R. A. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.10.020 · Cited by 99 · see citing works
Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways
Slominski, A. T., Zmijewski, M. A., Semak, I. V., Zbytek, B., Pisarchik, A. V., Li, W., Zjawiony, J. K., & Tuckey, R. C. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/18715206113139990308 · Cited by 91 · see citing works
Larsson, H., Böttiger, Y., Iuliano, L., & Diczfalusy, U. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.04.033 · Cited by 84 · see citing works
Newman, A. E. M., MacDougall‐Shackleton, S. A., An, Y., Kriengwatana, B. P., & Soma, K. K. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22395 · Cited by 82 · see citing works
Hennebert, O., Chalbot, S., Alran, S., & Morfin, R. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.03.026 · Cited by 79 · see citing works
Self-citationCutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity
Slominski, A. T., Manna, P. R., & Tuckey, R. C. (2014) · Experimental Dermatology · doi:10.1111/exd.12376 · Cited by 79 · see citing works
Local amplification of glucocorticoids in the aging brain and impaired spatial memory
Yau, J. L. W., & Seckl, J. R. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00024 · Cited by 77 · see citing works
Baeyer-Villiger oxidation of DHEA, pregnenolone, and androstenedione by Penicillium lilacinum AM111
Kołek, T., Szpineter, A., & Świzdor, A. (2008) · Steroids · doi:10.1016/j.steroids.2008.07.008 · Cited by 61 · see citing works
Kolátorová, L., Vítků, J., Chlupáčová, T., Mohapl, M., & Hampl, R. (2015) · Steroids · doi:10.1016/j.steroids.2015.01.019 · Cited by 56 · see citing works
11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story
Odermatt, A., & Klusoňová, P. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.08.011 · Cited by 52 · see citing works
The native anti-glucocorticoid paradigm
Muller, C., Hennebert, O., & Morfin, R. F. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.03.001 · Cited by 53 · see citing works
Self-citationYantsevich, A. V., Dichenko, Y. V., MacKenzie, F., Mukha, D., Baranovsky, A. V., Gilep, A. A., Usanov, S. A., & Strushkevich, N. V. (2014) · FEBS Journal · doi:10.1111/febs.12733 · Cited by 46 · see citing works
Makin, H. L. J., Honour, J. W., Shackleton, C. H. L., & Griffiths, W. J. (2010) · Springer eBooks · doi:10.1023/b135931_3 · Cited by 45 · see citing works
Steroid signaling: Ligand-binding promiscuity, molecular symmetry, and the need for gating
Lathe, R., & Kotelevtsev, Y. V. (2014) · Steroids · doi:10.1016/j.steroids.2014.01.002 · Cited by 43 · see citing works
Hennebert, O., Pélissier, M. A., Mée, S. L., Wülfert, E., & Morfin, R. F. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.12.014 · Cited by 43 · see citing works
Self-citationOdermatt, A., & Nashev, L. G. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.01.007 · Cited by 42 · see citing works
Nashev, L. G., Chandsawangbhuwana, C., Balázs, Z., Atanasov, A. G., Dick, B., Frey, F. J., Baker, M. E., & Odermatt, A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000561 · Cited by 42 · see citing works
Auci, D. L., Reading, C. L., & Frincke, J. M. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2008.11.011 · Cited by 40 · see citing works
Cascade biotransformation of dehydroepiandrosterone (DHEA) by Beauveria species
Kozłowska, E., Urbaniak, M., Hoc, N., Grzeszczuk, J., Dymarska, M., Stępień, Ł., Pląskowska, E., Kostrzewa-Susłow, E., & Janeczko, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-31665-2 · Cited by 38 · see citing works
Pinnock, S. B., Lazic, S. E., Wong, H. T., Wong, I., & Herbert, J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.035 · Cited by 38 · see citing works
Kołek, T., Milecka‐Tronina, N., Świzdor, A., Panek, A., & Białońska, A. (2011) · Organic & Biomolecular Chemistry · doi:10.1039/c1ob05350g · Cited by 34 · see citing works
Hennebert, O., Pernelle, C., Ferroud, C., & Morfin, R. F. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.11.021 · Cited by 34 · see citing works
Self-citationDehydroepiandrosterone Metabolites and their Interactions in Humans
Chalbot, S., & Morfin, R. F. (2006) · Drug metabolism and drug interactions · doi:10.1515/dmdi.2006.22.1.1 · Cited by 33 · see citing works
Self-citationMée, S. L., Hennebert, O., Ferrec, C., Wülfert, E., & Morfin, R. F. (2008) · Steroids · doi:10.1016/j.steroids.2008.05.001 · Cited by 33 · see citing works
Self-citationEvolution of 11β‐hydroxysteroid dehydrogenase‐type 1 and 11β‐hydroxysteroid dehydrogenase‐type 3
Baker, M. E. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.03.036 · Cited by 29 · see citing works
Hennebert, O., Montes, M., Favre-Reguillon, A., Chermette, H., Ferroud, C., & Morfin, R. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.12.015 · Cited by 27 · see citing works
Self-citationHunter, A. C., Mills, P. W., Dedi, C., & Dodd, H. T. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.09.022 · Cited by 27 · see citing works
Alteration of the steroidogenesis in boys with autism spectrum disorders
Janšáková, K., Hill, M., Čelárová, D., Celušáková, H., Repiská, G., Bičı́ková, M., Máčová, L., & Ostatníková, D. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01017-8 · Cited by 26 · see citing works
Newman, A. E. M., Zanette, L., Clinchy, M., Goodenough, N., & Soma, K. K. (2012) · Stress · doi:10.3109/10253890.2012.723076 · Cited by 25 · see citing works
Balázs, Z., Nashev, L. G., Chandsawangbhuwana, C., Baker, M. E., & Odermatt, A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.021 · Cited by 25 · see citing works
7α-Hydroxytestosterone Affects 11β-Hydroxysteroid Dehydrogenase 1 Direction in Rat Leydig Cells
Hu, G., Lian, Q., Chen, B., Prasad, P. V., Kumar, N., Zheng, Z., & Ge, R. (2009) · Endocrinology · doi:10.1210/en.2009-0917 · Cited by 25 · see citing works
Steroid hormones in prediction of normal pressure hydrocephalus
Kolátorová, L., Hill, M., Mohapl, M., Vítků, J., & Hampl, R. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.05.004 · Cited by 25 · see citing works
Neuroimmunomodulatory steroids in Alzheimer dementia
Hampl, R., & Bičı́ková, M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.02.007 · Cited by 23 · see citing works
Reading, C. L., Frincke, J. M., & White, S. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032147 · Cited by 21 · see citing works
Vaňková, M., Hill, M., Velíková, M., Včelák, J., Vacínová, G., Dvořáková, K., Lukášová, P., Vejražková, D., Rusina, R., Holmerová, I., et al. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.12.011 · Cited by 21 · see citing works
Hána, V., Ježková, J., Kršek, M., Kršek, M., Hána, V., & Hill, M. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01926 · Cited by 21 · see citing works
The metabolism of steroids, toxins and drugs by 11β-hydroxysteroid dehydrogenase 1
Zhou, H.-Y., Hu, G., Lian, Q., Morris, D. J., & Ge, R. (2011) · Toxicology · doi:10.1016/j.tox.2011.11.012 · Cited by 19 · see citing works
Ahlem, C. N., Page, T. M., Auci, D. L., Kennedy, M. R., Mangano, K., Nicoletti, F., Ge, Y., Huang, Y., White, S. K., Villegas, S. L., et al. (2010) · Steroids · doi:10.1016/j.steroids.2010.10.005 · Cited by 19 · see citing works
The 7-hydroxylation of dehydroepiandrosterone in rat brain
Li, A., & Bigelow, J. C. (2010) · Steroids · doi:10.1016/j.steroids.2010.02.003 · Cited by 19 · see citing works
Kozłowska, E., Dymarska, M., Kostrzewa-Susłow, E., & Janeczko, T. (2017) · Molecules · doi:10.3390/molecules22091511 · Cited by 18 · see citing works
Penno, C. A., Morgan, S., Vuorinen, A., Schuster, D., Lavery, G. G., & Odermatt, A. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m042499 · Cited by 15 · see citing works
Dias, T. R., Alves, M. G., Almeida, S., Silva, J., Barros, A., Sousa, M., Silva, B. M., Silvestre, S., & Oliveira, P. F. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.06.004 · Cited by 14 · see citing works
Hennebert, O., LEMEE, S., Pernelle, C., & Morfin, R. F. (2007) · Steroids · doi:10.1016/j.steroids.2007.07.011 · Cited by 14 · see citing works
Self-citationA Potential Role for 5‐Androstene‐3β,7β,17β‐triol in Obesity and Metabolic Syndrome
Auci, D. L., Ahlem, C. N., Kennedy, M. R., Page, T. M., Reading, C. L., & Frincke, J. M. (2010) · Obesity · doi:10.1038/oby.2010.204 · Cited by 13 · see citing works
Ahlem, C. N., Auci, D. L., Nicoletti, F., Pieters, R. H. H., Kennedy, M. R., Page, T. M., Reading, C. L., Enioutina, E. Y., & Frincke, J. M. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.04.010 · Cited by 13 · see citing works
Morris, D. J., Brem, A. S., & Odermatt, A. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105988 · Cited by 13 · see citing works
New insights into the protective effects of DHEA 1)
Niro, S., Hennebert, O., & Morfin, R. F. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.050 · Cited by 11 · see citing works
Self-citationA novel radioimmunoassay of 7-oxo-DHEA and its physiological levels
Kazihnítková, H., Zamrazilová, L., Hill, M., Lapčı́k, O., Pouzar, V., & Hampl, R. (2006) · Steroids · doi:10.1016/j.steroids.2006.12.005 · Cited by 11 · see citing works
Increased Serum Levels of C21 Steroids in Female Patients With Multiple Sclerosis
Kančeva, R., Stárka, L., Kancheva, L., Hill, M., Velíková, M., & Havrdová, E. (2015) · Physiological Research · doi:10.33549/physiolres.933145 · Cited by 11 · see citing works
Ahlem, C. N., Kennedy, M. R., Page, T. M., Reading, C. L., White, S. K., McKenzie, J. J., Cole, P. I., Stickney, D. R., & Frincke, J. M. (2011) · PubMed Central · Cited by 10 · see citing works
Gottfried‐Blackmore, A., Jellinck, P. H., Vecchiarelli, H. A., Masheeb, Z., Kaufmann, M., McEwen, B. S., & Bulloch, K. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.07.001 · Cited by 9 · see citing works
Steroid Hormones and Homocysteine in the Outcome of Patients With Normal Pressure Hydrocephalus
SOSVOROVA, L., Mohapl, M., Hill, M., Stárka, L., BICIKOVA, M., Vítků, J., Kančeva, R., BEŠŤÁK, J., & Hampl, R. (2015) · Physiological Research · doi:10.33549/physiolres.933072 · Cited by 8 · see citing works
Kolátorová, L., Šarek, J., Vítků, J., & Kvasnica, M. (2016) · Steroids · doi:10.1016/j.steroids.2016.05.001 · Cited by 8 · see citing works
Hou, Z., Yang, T., Mei, Z., Zhang, S., Gao, Y., Chen, X., Tan, Q., Zhu, X., Xu, C., Lian, J., et al. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105859 · Cited by 8 · see citing works
7-oxygenated Derivatives of Dehydroepiandrosterone and Obesity
Sedláčková, B., Dušátková, L., Zamrazilová, H., Matucha, P., Bičı́ková, M., & Stárka, L. (2012) · Prague Medical Report · doi:10.14712/23362936.2015.29 · Cited by 8 · see citing works
Dehydroepiandrosterone (DHEA) and DHEA Sulfate: Roles in Brain Function and Disease
Quinn, T., Robinson, S. R., & Walker, D. W. (2018) · InTech eBooks · doi:10.5772/intechopen.71141 · Cited by 8 · see citing works
Zhu, Q., Dong, Y., Li, X., Ni, C., Huang, T., Sun, J., & Ge, R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00886 · Cited by 7 · see citing works
Ke, Y., Gonthier, R., Simard, J.-N., & Labrie, F. (2016) · Steroids · doi:10.1016/j.steroids.2016.02.005 · Cited by 7 · see citing works
Kiersztan, A., Nagalski, A., Nalepa, P., Tempes, A., Trojan, N., Usarek, M., & Jagielski, A. K. (2015) · Biochimie · doi:10.1016/j.biochi.2015.11.019 · Cited by 7 · see citing works
Reduced Levels of Circulating 7α-Hydroxy-Dehydroepiandrosterone in Treated Adolescent Obese Patients
Máčová, L., Bičı́ková, M., Zamrazilová, H., Hill, M., Kazihnítková, H., Sedláčková, B., & Stárka, L. (2014) · Physiological Research · doi:10.33549/physiolres.932540 · Cited by 6 · see citing works
A native steroid hormone derivative triggers the resolution of inflammation
Niro, S., Hennebert, O., & Morfin, R. F. (2009) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.001 · Cited by 6 · see citing works
Self-citationBaker, M. E. (2010) · Nature Precedings · doi:10.1038/npre.2010.4296.1 · Cited by 6 · see citing works
Steroid Hormones Related to 11β-hydroxysteroid Dehydrogenase Type 1 in Treated Obesity
Máčová, L., SOSVOROVÁ, L., Vítků, J., Bičı́ková, M., Hill, M., Zamrazilová, H., Sedláčková, B., & Stárka, L. (2015) · Physiological Research · doi:10.33549/physiolres.933073 · Cited by 4 · see citing works
Yoshimoto, F. K., Arman, H. D., Griffith, W. P., Yan, F., & Wherritt, D. (2017) · Steroids · doi:10.1016/j.steroids.2017.10.004 · Cited by 4 · see citing works
Analysis of Androgens and Their Derivatives
Gower, D. B. (2010) · Springer eBooks · doi:10.1023/b135931_6 · Cited by 3 · see citing works
Diazepane–acetamide derivatives as selective 11β-hydroxysteroid dehydrogenase type 1 inhibitors
Odermatt, A. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770902911490 · Cited by 2 · see citing works
Gergely, A., Horváth, P., Szász, G., & Veress, G. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2917-3 · Cited by 1 · see citing works
Caractéristiques immuno-analytiques de la déhydroépiandrostérone et de son sulfate
Doggui, R. (2012) · Immuno-analyse & Biologie Spécialisée · doi:10.1016/j.immbio.2012.05.004 · Cited by 1 · see citing works
Breakdown and clearance of steroids
Honour, J. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818124-9.00001-2 · Cited by 1 · see citing works
Resolution of Colitis-Associated Inflammation
Hennebert, O., Pélissier, M. A., & Morfin, R. F. (2012) · InTech eBooks · doi:10.5772/26779
Self-citation
- Authors
- Muller, C., Pompon, D., Urban, P., & Morfin, R.
- Affiliations
- Conservatoire National des Arts et Métiers (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Morfin, Robert
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 99
- Issue
- 4-5
- Pages
- 215-222
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2076615745
- Cited by
- 77
- References
- 39
- Citations by year
- 2023: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 8 · 2014: 7 · 2013: 3 · 2012: 7
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- dehydroepiandrosterone, 11β-hydroxysteroid dehydrogenase type 1, enzyme kinetics, CYP7B1, glucocorticoid metabolism
- MeSH terms
- Base Sequence, Chromatography, Thin Layer, Cortisone, Dehydroepiandrosterone, Genetic Vectors, Humans, Hydrocortisone, Kinetics, Substrate Specificity, DNA Primers, 11-beta-Hydroxysteroid Dehydrogenase Type 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
