Liposomal glucocorticoids as tumor-targeted anti-angiogenic nanomedicine in B16 melanoma-bearing mice.
Abstract
This study evaluates whether the inhibitory effects of prednisolone phosphate (PLP) encapsulated in long-circulating liposomes (LCL-PLP) on tumor growth and tumor angiogenesis described previously can be generalized to other types of glucocorticoids (GC) encapsulated in LCL (LCL-GC). Four types of synthetic GC, i.e. budesonide disodium phosphate (BUP), dexamethasone disodium phosphate (DXP), methylprednisolone disodium phosphate (MPLP), and PLP, were selected based on the difference in their potency to activate the human glucocorticoid receptor. The effects of all LCL-GC on the production of angiogenic/inflammatory factors in vivo in the B16.F10 murine melanoma model as well as on the viability and proliferation of tumor cells and endothelial cells in vitro were investigated. Our results show that all four selected LCL-GC formulations inhibit tumor growth, albeit to different degrees. The differences in antitumor activity of LCL-GC correlate with their efficacy to suppress tumor angiogenesis and inflammation. The strongest antitumor effect is achieved by LCL-encapsulated BUP (LCL-BUP), due to the highest potency of BUP versus the other three GC types. The in vitro results presented herein suggest that LCL-BUP has strong cytotoxic effects on B16.F10 melanoma cells and the anti-proliferative effects of all LCL-GC towards angiogenic endothelial cells play a role in their antitumor activity.
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Storm and coworkers described successful treatment of B6F10 murine melanoma by nano-liposomes passively loaded with prednisolone phosphate, with the underlying mechanism described as inhibition of angiogenesis.
“Recently, Storm and coworkers [15], [48] described a successful treatment of B6F10 murine melanoma by nano-liposomes passively loaded with the GC water-soluble prodrug prednisolone phosphate, where the underlying mechanism was described as inhibition of angiogenesis [15].”
From Fabrication Principles and Their Contribution to the Superior In Vivo Therapeutic Efficacy of Nano-Liposomes Remote Loaded with Glucocorticoids (2011) · cites this paper as [15]
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- Authors
- Banciu, M., Metselaar, J. M., Schiffelers, R. M., & Storm, G.
- Affiliations
- Utrecht University (NL)
- Corresponding author
- Banciu, Manuela
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 111
- Issue
- 1-2
- Pages
- 101-110
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2064137717
- Cited by
- 63
- References
- 55
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 9 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- long-circulating liposomes, tumor angiogenesis, B16F10 melanoma, glucocorticoid receptor, tumor growth inhibition, tumor inflammation, endothelial cell proliferation, tumor cell killing
- MeSH terms
- Animals, Cell Survival, Cells, Cultured, Colonic Neoplasms, Dexamethasone, Dose-Response Relationship, Drug, Endothelium, Vascular, Glucocorticoids, Inflammation, Injections, Subcutaneous, Liposomes, Male, Melanoma, Experimental, Methylprednisolone, Mice, Inbred C57BL, Neovascularization, Pathologic, Prednisolone, Receptors, Glucocorticoid, Time Factors, Umbilical Veins, Drug Delivery Systems, Budesonide, Cell Line, Tumor, Tumor Burden, Cell Proliferation, Nanomedicine, Mice
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