Multiple roles for UDP-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes in androgen metabolism and prostate cancer evolution
Abstract
In the prostate, approximately 50% of androgens are from adrenal steroids, mainly dehydroepiandrosterone (DHEA), its sulfate and androstenedione. These compounds are converted first into testosterone, and then into the active hormone dihydrotestosterone (DHT). After having activated the androgen receptor (AR), DHT is reduced into androstane-3α-DIOL (3α-DIOL) and androsterone (ADT), which are subsequently converted into 2 inactive and easily excretable metabolites: 3α-DIOL-17glucuronide (3α-DIOL-17G) and ADT-3glucuronide (ADT-3G). The formation of these last derivatives through the glucuronidation reaction involves 2 UDP-glucuronosyltransferase (UGT) enzymes, namely UGT2B15 and UGT2B17. The present review article aims at providing a comprehensive view of the physiological and pharmacological importance of these 2 enzymes for the control of androgen homeostasis. We will resume: (i) how UGT2B15 and UGT2B17 contribute to androgen elimination; (ii) how their glucuronidation capacity influences the androgen signaling pathway in prostate cells; (iii) how they contribute to the anti-proliferative properties of AR antagonists in prostate cancer cells; and (iv) how AR and its spliced variants regulate the UGT2B15 and/or UGT2B17 genes expression. Finally, whether the unexploited AR-UGT axis could serve as a prognostic maker or a pharmacological target for novel therapeutics in the treatment of prostate cancer is also discussed. This article is part of a special issue entitled 'Essential role of DHEA'.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Down-regulation of UGTs in prostate cancer promotes intratumoral androgen accumulation.
“Genetic variations of UGTs significantly contribute to prostate cancer risk and progression and there is evidence for a down-regulation of UGTs in prostate cancer promoting intratumoral androgen accumulation (Barbier and Belanger, 2008, Gauthier-Landry et al., 2015).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Gauthier-Landry et al., 2015
Genetic variations of UGTs significantly contribute to prostate cancer risk and progression.
“Genetic variations of UGTs significantly contribute to prostate cancer risk and progression and there is evidence for a down-regulation of UGTs in prostate cancer promoting intratumoral androgen accumulation (Barbier and Belanger, 2008, Gauthier-Landry et al., 2015).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Gauthier-Landry et al., 2015
Cites
Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21208 · Cited by 11,499 · see citing works
Molecular determinants of resistance to antiandrogen therapy
Chen, C. D., Welsbie, D. S., Tran, C., Baek, S. H., Chen, R., Vessella, R., Rosenfeld, M. G., & Sawyers, C. L. (2004) · Nature Medicine · doi:10.1038/nm972 · Cited by 2,278 · see citing works
Montgomery, R. B., Mostaghel, E. A., Vessella, R., Hess, D. L., Kalhorn, T. F., Higano, C. S., True, L. D., & Nelson, P. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0249 · Cited by 1,419 · see citing works
Androgen Deprivation Therapy for Prostate Cancer
Sharifi, N. (2005) · JAMA · doi:10.1001/jama.294.2.238 · Cited by 1,087 · see citing works
Glucuronidation of Drugs and Other Compounds
Dutton, G. J. (2019) · Chapman & Hall/CRC eBooks · doi:10.1201/9780429264177 · Cited by 804 · see citing works
Locke, J. A., Guns, E. S., Lubik, A. A., Adomat, H. H., Hendy, S. C., Wood, C. A., Ettinger, S. L., Gleave, M. E., & Nelson, C. C. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5997 · Cited by 747 · see citing works
Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685 · see citing works
Li, Y.-M., Chan, S.-C., Brand, L., Hwang, T., Silverstein, K., & Dehm, S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-3630 · Cited by 663 · see citing works
Mostaghel, E. A., Marck, B. T., Plymate, S. R., Vessella, R. L., Balk, S. P., Matsumoto, A. M., Nelson, P. S., & Montgomery, B. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0728 · Cited by 583 · see citing works
Mostaghel, E. A., Page, S. T., Lin, D. W., Fazli, L., Coleman, I. M., True, L. D., Knudsen, B., Hess, D. L., Nelson, C. C., Matsumoto, A. M., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3332 · Cited by 529 · see citing works
STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES*
Radominska-p, A., Czernik, P. J., Little, J. M., Battaglia, E., & Mackenzie, P. I. (1999) · Drug Metabolism Reviews · doi:10.1081/dmr-100101944 · Cited by 497 · see citing works
The program of androgen-responsive genes in neoplastic prostate epithelium
Nelson, P. S., Clegg, N. J., Arnold, H., Ferguson, C., Bonham, M. J., White, J., Hood, L., & Lin, B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182376299 · Cited by 483 · see citing works
The intranuclear binding of testosterone and 5α-androstan-17β-ol-3-one by rat prostate
Bruchovsky, N., & Wilson, J. D. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94513-8 · Cited by 404 · see citing works
Androgen receptor: A key molecule in the progression of prostate cancer to hormone independence
Taplin, M., & Balk, S. P. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10653 · Cited by 392 · see citing works
AR, the cell cycle, and prostate cancer
Balk, S. P., & Knudsen, K. E. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06001 · Cited by 338 · see citing works
Turgeon, D., Carrier, J.-S., Lévesque, E., Hum, D. W., & Bélanger, A. (2001) · Endocrinology · doi:10.1210/endo.142.2.7958 · Cited by 333 · see citing works
Self-citationMechanisms of the androgen receptor splicing in prostate cancer cells
Liu, L. L., Xie, N., Sun, S., Plymate, S. R., Mostaghel, E. A., & Dong, X. (2013) · Oncogene · doi:10.1038/onc.2013.284 · Cited by 313 · see citing works
Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development
Cunha, G. R., Ricke, W. A., Thomson, A. A., Marker, P. C., Risbridger, G. P., Hayward, S. W., Wang, Y. Z., Donjacour, A. A., & Kurita, T. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.10.017 · Cited by 310 · see citing works
Hormonal Predictors of Prostate Cancer: A Meta-Analysis
Shaneyfelt, T. M., Husein, R., Bubley, G. J., & Mantzoros, C. S. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.4.847 · Cited by 309 · see citing works
Jakobsson, J., Ekström, L., Inotsume, N., Garle, M., Lorentzon, M., Ohlsson, C., Roh, H., Carlström, K., & Rane, A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1643 · Cited by 282 · see citing works
Labrie, F., Dupont, A., Bèlanger, A., Cusan, L., Lacourcière, Y., Monfette, G., LaBerge, J., Emond, J., Fazekas, A. T. A., Raynaud, J., et al. (1982) · PubMed · Cited by 276 · see citing works
Self-citationSTRUCTURE AND FUNCTION OF URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASES
Meech, R., & Mackenzie, P. I. (1997) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1997.tb02718.x · Cited by 267 · see citing works
GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE
Wells, P. G., Mackenzie, P. I., Roy Chowdhury, J., Guillemette, C., Gregory, P. A., Ishii, Y., Hansen, A. J., Kessler, F. K., Kim, P. M., Roy Chowdhury, N., et al. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.32.3.281 · Cited by 260 · see citing works
Coviello, A. D., Haring, R., Wellons, M., Vaidya, D., Lehtimäki, T., Keildson, S., Lunetta, K. L., He, C., Fornage, M., Lagou, V., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002805 · Cited by 250 · see citing works
Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases
Zhang, X., Morrissey, C. M., Sun, S., Ketchandji, M., Nelson, P. S., True, L. D., Vakar‐Lopez, F., Vessella, R. L., & Plymate, S. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027970 · Cited by 240 · see citing works
Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans
Bélanger, A., Pelletier, G., Labrie, F., Barbier, O., & Chouinard, S. (2003) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2003.10.005 · Cited by 235 · see citing works
Self-citationLévesque, É., Beaulieu, M., Green, M. D., Tephly, T. R., Bélanger, A., & Hum, D. W. (1997) · Pharmacogenetics · doi:10.1097/00008571-199708000-00007 · Cited by 218 · see citing works
Self-citationHormones and prostate cancer: Current perspectives and future directions
Hsing, A. W., Reichardt, J. K. V., & Stanczyk, F. Z. (2002) · The Prostate · doi:10.1002/pros.10108 · Cited by 208 · see citing works
THE RESULTS OF DOUBLE CASTRATION IN HYPERTROPHY OF THE PROSTATE
WHITE, J. W. (1895) · Annals of Surgery · doi:10.1097/00000658-189507000-00001 · Cited by 194 · see citing works
Transcriptional programs activated by exposure of human prostate cancer cells to androgen
DePrimo, S. E., Diehn, M., Nelson, J. B., Reiter, R. E., Matese, J. C., Fero, M., Tibshirani, R. J., Brown, P. O., & Brooks, J. D. (2002) · Genome biology · doi:10.1186/gb-2002-3-7-research0032 · Cited by 193 · see citing works
Beaulieu, M., Lávesque, E., Hum, D. W., & Bálanger, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22855 · Cited by 187 · see citing works
Self-citationNew Strategies in Metastatic Prostate Cancer: Targeting the Androgen Receptor Signaling Pathway
Attard, G., Richards, J., & Bono, J. S. D. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0567 · Cited by 184 · see citing works
Gonadotropin-Releasing Hormone Agonists in the Treatment of Prostate Cancer
Labrie, F., Bélanger, A., Luu-The, V., Labrie, C., Simard, J., Cusan, L., Gomez, J., & Candas, B. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0017 · Cited by 169 · see citing works
Self-citationCharacterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15
Wilson, W., de Villena, F. P., Lyn‐Cook, B. D., Chatterjee, P. K., Bell, T. A., Detwiler, D. A., Gilmore, R. C., Valladeras, I. C., Wright, C. C., Threadgill, D. W., et al. (2004) · Genomics · doi:10.1016/j.ygeno.2004.06.011 · Cited by 155 · see citing works
Secondary Hormonal Therapy for Advanced Prostate Cancer
Lam, J. S., Leppert, J. T., Vemulapalli, S. N., Shvarts, O., & Belldegrun, A. S. (2006) · Journal of Urology · doi:10.1016/s0022-5347(05)00034-0 · Cited by 153 · see citing works
UGT genomic diversity: beyond gene duplication
Guillemette, C., Lévesque, É., Harvey, M., Bellemare, J., & Ménard, V. (2009) · Drug Metabolism Reviews · doi:10.3109/03602530903210682 · Cited by 134 · see citing works
Castration-resistant prostate cancer: Adaptive responses in the androgen axis
Egan, A., Dong, Y., Zhang, H., Qi, Y., Balk, S. P., & Sartor, O. A. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.09.011 · Cited by 125 · see citing works
Cunningham, J. M., Hebbring, S. J., McDonnell, S. K., Cicek, M. S., Christensen, G. B., Wang, L., Jacobsen, S. J., Cerhan, J. R., Blute, M. L., Schaid, D. J., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0767 · Cited by 120 · see citing works
Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase
Jedlitschky, G., Cassidy, A., Sales, M., Pratt, N. R., & Burchell, B. (1999) · Biochemical Journal · doi:10.1042/bj3400837 · Cited by 118 · see citing works
Chouinard, S., Barbier, O., & Bélanger, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703370200 · Cited by 109 · see citing works
Self-citationLévesque, É., Girard, H., Journault, K., Lépine, J., & Guillemette, C. (2006) · Hepatology · doi:10.1002/hep.21464 · Cited by 96 · see citing works
Sun, F., Chen, H.-G., Li, W., Yang, X., Wang, X., Jiang, R., Guo, Z., Chen, H., Huang, J., Borowsky, A. D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.492140 · Cited by 93 · see citing works
Girard, H., Lévesque, É., Bellemare, J., Journault, K., Caillier, B., & Guillemette, C. (2007) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3282f1f118 · Cited by 93 · see citing works
Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling
Chouinard, S., Yueh, M.-F., Tukey, R. H., Giton, F., Fiet, J., Pelletier, G., Barbier, O., & Bélanger, A. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.016 · Cited by 90 · see citing works
Self-citationMacLeod, S. L., Nowell, S. A., Plaxco, J., & Lang, N. P. (2000) · Annals of Surgical Oncology · doi:10.1007/s10434-000-0777-3 · Cited by 88 · see citing works
Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate
Barbier, O., & Bélanger, A. (2008) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.01.001 · Cited by 86 · see citing works
Self-citationGsur, A. (2002) · Carcinogenesis · doi:10.1093/carcin/23.10.1647 · Cited by 85 · see citing works
Androgen receptor mediates the expression of UDP‐glucuronosyltransferase 2 B15 and B17 genes
Bao, B., Chuang, B., Wang, Q., Sartor, O., Balk, S. P., Brown, M. A., Kantoff, P. W., & Lee, G. M. (2008) · The Prostate · doi:10.1002/pros.20749 · Cited by 78 · see citing works
BEAULIEU, M., Lévesque, É., Tchernof, A., Beatty, B., Bélanger, A., & Hum, D. W. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.1143 · Cited by 77 · see citing works
Self-citationPark, J. M., Chen, L., Shade, K., Lazarus, P. J., Seigne, J. D., Patterson, S. G., Helal, M. A., & Pow‐Sang, J. M. (2004) · The Journal of Urology · doi:10.1097/01.ju.0000117748.44313.43 · Cited by 76 · see citing works
Endocrine Control of Prostatic Cancer
Huggins, C. (1943) · Science · doi:10.1126/science.97.2529.541 · Cited by 68 · see citing works
Nadeau, G., Bellemare, J., Audet‐Walsh, É., Flageole, C., Huang, S., Bao, B., Douville, P., Caron, P., Fradet, Y., Lacombe, L., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1049 · Cited by 58 · see citing works
Chouinard, S., Pelletier, G., Bélanger, A., & Barbier, O. (2004) · Endocrine Research · doi:10.1081/erc-200044014 · Cited by 57 · see citing works
Self-citationTherapeutic options for hormone-refractory prostate cancer in 2007
Hadaschik, B. A., & Gleave, M. E. (2007) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2007.05.010 · Cited by 57 · see citing works
Molecular pathology of prostate cancer
Konishi, N., Shimada, K., Ishida, E., & Nakamura, M. (2005) · Pathology International · doi:10.1111/j.1440-1827.2005.01865.x · Cited by 53 · see citing works
Chouinard, S., Pelletier, G., Bélanger, A., & Barbier, O. (2006) · Endocrinology · doi:10.1210/en.2006-0229 · Cited by 53 · see citing works
Self-citationAbiraterone and Novel Antiandrogens: Overcoming Castration Resistance in Prostate Cancer
Ferraldeschi, R., Pezaro, C. J., Karavasilis, V., & Bono, J. S. D. (2012) · Annual Review of Medicine · doi:10.1146/annurev-med-121211-091605 · Cited by 52 · see citing works
Hajdinjak, T., & Zagradišnik, B. (2004) · The Prostate · doi:10.1002/pros.20024 · Cited by 51 · see citing works
Genomic organization of the UGT2b gene cluster on human chromosome 4q13
Riedy, M., Wang, J.-Y., Miller, A. P., Buckler, A., Hall, J., & Guida, M. (2000) · Pharmacogenetics · doi:10.1097/00008571-200004000-00006 · Cited by 49 · see citing works
Grosse, L., Pâquet, S., Caron, P., Fazli, L., Rennie, P. S., Bélanger, A., & Barbier, O. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1462 · Cited by 49 · see citing works
Self-citationThe transcriptional programme of the androgen receptor ( AR ) in prostate cancer
Lamb, A. D. G., Massie, C. E., & Neal, D. E. (2013) · British Journal of Urology · doi:10.1111/bju.12415 · Cited by 48 · see citing works
Okugi, H., Nakazato, H., Matsui, H., Ohtake, N., Nakata, S., & Suzuki, K. (2006) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2006.04.004 · Cited by 47 · see citing works
Bellemare, J., Rouleau, M., Harvey, M., & Guillemette, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.083139 · Cited by 47 · see citing works
Pâquet, S., Fazli, L., Grosse, L., Verreault, M., Têtu, B., Rennie, P. S., Bélanger, A., & Barbier, O. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2064 · Cited by 44 · see citing works
Self-citationFrick, J., & Aulitzky, W. (1991) · Infection · doi:10.1007/bf01643679 · Cited by 38 · see citing works
Mechanism of GnRH action in gonadotrophs
Clayton, R. N. (1988) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136732 · Cited by 36 · see citing works
Correlation between circulatory, local prostatic, and intra‐prostatic androgen levels
Olsson, M., Ekström, L., Guillemette, C., Bélanger, A., Rane, A., & Gustafsson, O. (2010) · The Prostate · doi:10.1002/pros.21307 · Cited by 35 · see citing works
Self-citationProstate Cancer with Variants in CYP17 and UGT2B17 Genes: A Meta-Analysis
Cai, L., Huang, W., & Chou, K. (2012) · Protein and Peptide Letters · doi:10.2174/092986612798472848 · Cited by 33 · see citing works
Guillemette, C., Hum, D. W., & Bèlanger, A. (1996) · Endocrinology · doi:10.1210/endo.137.7.8770908 · Cited by 32 · see citing works
Self-citationMetastatic Castration-Resistant Prostate Cancer: Critical Review of Enzalutamide
El-Amm, J., Patel, N., Freeman, A. T., & Aragon‐Ching, J. B. (2013) · Clinical Medicine Insights Oncology · doi:10.4137/cmo.s11670 · Cited by 32 · see citing works
Sun, T., Oh, W. K., Jacobus, S. J., Regan, M. M., Pomerantz, M. M., Freedman, M. L., Lee, G. M., & Kantoff, P. W. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0283 · Cited by 31 · see citing works
Bellemare, J., Rouleau, M., Harvey, M., Têtu, B., & Guillemette, C. (2009) · The Pharmacogenomics Journal · doi:10.1038/tpj.2009.64 · Cited by 30 · see citing works
Grant, D. J., Hoyo, C., Oliver, S., Gerber, L., Shuler, K., Calloway, E. E., Freedland, A. R., McPhail, M. E., Livingston, J. N., Richardson, R. M., et al. (2012) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2012.0161 · Cited by 29 · see citing works
Bellemare, J., Rouleau, M., Girard, H., Harvey, M., & Guillemette, C. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.034835 · Cited by 26 · see citing works
New Therapeutics to Treat Castrate‐Resistant Prostate Cancer
Acar, Ö., Esen, T., & Lack, N. A. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/379641 · Cited by 25 · see citing works
Lévesque, É., Ménard, V., Laverdière, I., Bellemare, J., Barbier, O., Girard, H., & Guillemette, C. (2010) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328336ef1c · Cited by 25 · see citing works
Self-citationVidal, A. C., Tucker, C., Schildkraut, J. M., Richardson, R. M., McPhail, M. E., Freedland, S. J., Hoyo, C., & Grant, D. J. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-556 · Cited by 24 · see citing works
Polymorphisms in androgen signaling pathway predisposing to prostate cancer
Schleutker, J. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.007 · Cited by 23 · see citing works
UGT2B17 Polymorphism and Risk of Prostate Cancer: A Meta-Analysis
Kpoghomou, M.-A., Soatiana, J. E., Kalembo, F. W., Bishwajit, G., & Sheng, W. (2013) · ISRN Oncology · doi:10.1155/2013/465916 · Cited by 22 · see citing works
Nuclear receptors and endobiotics glucuronidation: the good, the bad, and the UGT
Bigo, C., Caron, S., Dallaire-Théroux, A., & Barbier, O. (2013) · Drug Metabolism Reviews · doi:10.3109/03602532.2012.751992 · Cited by 21 · see citing works
Self-citationChemotherapy in the treatment of prostate cancer--is there a role?
Arianayagam, M., Chang, J., & Rashid, P. (2007) · PubMed · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 82 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms
Meech, R., Hu, D. G., McKinnon, R. A., Mubarokah, S. N., Haines, A. Z., Nair, P. C., Rowland, A., & Mackenzie, P. I. (2019) · Physiological Reviews · doi:10.1152/physrev.00058.2017 · Cited by 363 · see citing works
Intracrine androgen biosynthesis, metabolism and action revisited
Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217 · see citing works
Drug metabolizing enzymes and their inhibitors' role in cancer resistance
Pathania, S., Bhatia, R., Baldi, A., Singh, R., & Rawal, R. K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.117 · Cited by 123 · see citing works
Bhatt, D. K., Basit, A., Zhang, H., Gaedigk, A., Lee, S., Claw, K. G., Mehrotra, A., Chaudhry, A. S., Pearce, R. E., Gaedigk, R., et al. (2018) · Drug Metabolism and Disposition · doi:10.1124/dmd.118.080952 · Cited by 78 · see citing works
Metabolomic profiling for the identification of novel diagnostic markers in prostate cancer
Lucarelli, G. T., Rutigliano, M., Galleggiante, V., Giglio, A., Palazzo, S., Ferro, M., Simone, C., Bettocchi, C., Battaglia, M., & Ditonno, P. (2015) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2015.1069711 · Cited by 69 · see citing works
Drug metabolizing enzymes-associated chemo resistance and strategies to overcome it
Verma, H., Bahia, M. S., Choudhary, S., Singh, P. K., & Silakari, O. (2019) · Drug Metabolism Reviews · doi:10.1080/03602532.2019.1632886 · Cited by 63 · see citing works
Hu, D. G., Hulin, J.-A., Nair, P. C., Haines, A. Z., McKinnon, R. A., Mackenzie, P. I., & Meech, R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107414 · Cited by 55 · see citing works
Audet‐Walsh, É., Yee, T., Tam, I. S., & Giguère, V. (2017) · Endocrinology · doi:10.1210/en.2016-1926 · Cited by 46 · see citing works
Li, H., Xie, N., Chen, R., Verreault, M., Fazli, L., Gleave, M. E., Barbier, O., & Dong, X. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1518 · Cited by 43 · see citing works
Self-citationMohammad, O. S., Nyquist, M. D., Schweizer, M. T., Balk, S. P., Corey, E., Plymate, S. R., Nelson, P. S., & Mostaghel, E. A. (2017) · Cancers · doi:10.3390/cancers9120166 · Cited by 42 · see citing works
Liu, W., Li, J., Zhao, R., Lu, Y., & Huang, P. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1088458 · Cited by 42 · see citing works
Zhang, A., Zhang, J., Plymate, S. R., & Mostaghel, E. A. (2016) · Hormones and Cancer · doi:10.1007/s12672-016-0250-9 · Cited by 42 · see citing works
Margaillan, G., Lévesque, É., & Guillemette, C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.09.021 · Cited by 41 · see citing works
Steroid metabolism in breast cancer: Where are we and what are we missing?
Africander, D., & Storbeck, K. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.05.016 · Cited by 39 · see citing works
The relationship between UGT1A1 gene & various diseases and prevention strategies
Liu, D., Yu, Q., Ning, Q. X., Liu, Z., & Song, J. (2021) · Drug Metabolism Reviews · doi:10.1080/03602532.2021.2001493 · Cited by 34 · see citing works
Yang, M., Zhang, J., Li, Y., Han, X., Gao, K., & Fang, J. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.08.008 · Cited by 31 · see citing works
Nasr, T., Bondock, S., Youns, M., Fayad, W., & Zaghary, W. A. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.10.016 · Cited by 31 · see citing works
A homozygous mutation of GNRHR in a familial case diagnosed with polycystic ovary syndrome
Caburet, S., Beck‐Fruchter, R., Legois, B., Fellous, M., Shalev, S. A., & Veitia, R. A. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0968 · Cited by 27 · see citing works
Intracrinology-revisited and prostate cancer
Penning, T. M., & Detlefsen, A. J. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105499 · Cited by 22 · see citing works
Gunduz, M., Argikar, U. A., Cirello, A. L., & Dumouchel, J. L. (2018) · Drug Metabolism Letters · doi:10.2174/1872312812666180611113656 · Cited by 19 · see citing works
Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases
Riches, Z., & Collier, A. C. (2015) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2015.1028355 · Cited by 16 · see citing works
Jiang, T., Zheng, L., Jiang, H., Zhang, Z., Wang, K., Wang, Q., & Li, Q. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s92129 · Cited by 16 · see citing works
Qin, X., Liu, M., & Wang, X. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.02.021 · Cited by 16 · see citing works
Liu, H., Li, Q., Cheng, X., Wang, H., Wang, G., & Hao, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117051 · Cited by 15 · see citing works
Shafiee-Kermani, F., Carney, S. T., Jima, D. D., Utin, U. C., Farrar, L. B., Oputa, M. O., Hines, M. R., Kinyamu, H. K., Trotter, K. W., Archer, T., et al. (2020) · Epigenetics · doi:10.1080/15592294.2020.1795601 · Cited by 13 · see citing works
Lv, H., Wang, J., Wang, M., Shen, L., Xiao, L., Chen, T., Sun, T., Li, W., Zhu, L., & Zhang, X. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112039 · Cited by 13 · see citing works
Relevance of Human Aldoketoreductases and Microbial β-Glucuronidases in Testosterone Disposition
Basit, A., Amory, J. K., Mettu, V. S., Li, C. Y., Heyward, S. A., Jariwala, P. B., Redinbo, M. R., & Prasad, B. (2023) · Drug Metabolism and Disposition · doi:10.1124/dmd.122.000975 · Cited by 13 · see citing works
Steroid sulfates in domestic mammals and laboratory rodents
Schuler, G. C. (2021) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2021.106622 · Cited by 13 · see citing works
Habibi, M., Mirfakhraie, R., Khani, M., Rakhshan, A., Azargashb, E., & Pouresmaeili, F. (2017) · Gene · doi:10.1016/j.gene.2017.08.038 · Cited by 12 · see citing works
Sequence-Based Analysis of Lipid-Related Metabolites in a Multiethnic Study
Feofanova, E. V., Yu, B., Metcalf, G., Liu, X., Muzny, D. M., Below, J. E., Wagenknecht, L. E., Gibbs, R. A., Morrison, A. C., & Boerwinkle, E. (2018) · Genetics · doi:10.1534/genetics.118.300751 · Cited by 12 · see citing works
LXRs, SHP, and FXR in Prostate Cancer: Enemies or Ménage à Quatre With AR?
Cariello, M., Ducheix, S., Maqdasy, S., Baron, S., Moschetta, A., & Lobaccaro, J. A. (2018) · Nuclear Receptor Signaling · doi:10.1177/1550762918801070 · Cited by 11 · see citing works
AKR1C3 mediates pan‐AR antagonist resistance in castration‐resistant prostate cancer
Hertzog, J., Zhang, Z., Bignan, G., Connolly, P. J., Heindl, J. E., Janetopoulos, C., Rupnow, B. A., & McDevitt, T. M. (2020) · The Prostate · doi:10.1002/pros.24049 · Cited by 10 · see citing works
Canonical and Noncanonical Androgen Metabolism and Activity
Storbeck, K., & Mostaghel, E. A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-32656-2_11 · Cited by 10 · see citing works
Mostaghel, E. A., Zhang, A., & Plymate, S. R. (2015) · European Urology · doi:10.1016/j.eururo.2015.08.025 · Cited by 10 · see citing works
Li, H., Ji, C.-Y., Liu, Y., & Zhuang, C. (2016) · Annals of Human Biology · doi:10.1080/03014460.2016.1240232 · Cited by 9 · see citing works
Chanawong, A., Mackenzie, P. I., McKinnon, R. A., Hu, D. G., & Meech, R. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.240317 · Cited by 9 · see citing works
Regulation of Hepatic UGT2B15 by Methylation in Adults of Asian Descent
Oeser, S. G., Bingham, J., & Collier, A. C. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10010006 · Cited by 8 · see citing works
Cai, J., Huang, F., Gao, W., Gong, T., Chen, H., & Liu, Z. (2023) · Cancers · doi:10.3390/cancers15245719 · Cited by 7 · see citing works
Genetic and molecular determinants of prostate cancer among Iranian patients: An update
Ghayour‐Mobarhan, M., Ferns, G. A., & Moghbeli, M. (2019) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1657061 · Cited by 7 · see citing works
Zhan, H., Zhang, S., Li, L., Chen, Z., Cai, Y., Huang, J., Wu, D., Huang, B., Wu, B., & Liu, X. (2022) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2022.106117 · Cited by 6 · see citing works
Revisiting the roles of cAMP signalling in the progression of prostate cancer
Parsons, E. C., Hoffmann, R., & Baillie, G. S. (2023) · Biochemical Journal · doi:10.1042/bcj20230297 · Cited by 6 · see citing works
Intracrine androgen biosynthesis and drug resistance
Penning, T. M., Asangani, I. A., Sprenger, C. C. T., & Plymate, S. R. (2020) · Cancer Drug Resistance · doi:10.20517/cdr.2020.60 · Cited by 6 · see citing works
Gomes, L. R., Low, J. N., Turner, A. B., & Wardell, J. L. (2018) · Steroids · doi:10.1016/j.steroids.2018.07.005 · Cited by 4 · see citing works
Gomes, L. R., Low, J. N., Turner, A. B., Baddeley, T. C., & Wardell, J. L. (2018) · Steroids · doi:10.1016/j.steroids.2018.09.010 · Cited by 4 · see citing works
Therapeutic potential of targeting AKR1C2 in the treatment of prostate cancer
Nie, M., Li, T., Liu, P., & Wang, X. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09917-4 · Cited by 4 · see citing works
Wang, J., Cheng, L., Li, J., Wang, Y., Chen, S., Wang, Z., & Yang, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011265 · Cited by 3 · see citing works
Androgen metabolism genes in prostate cancer health disparities.
Liu, W., Liu, R., & Wang, L. (2017) · PubMed · doi:10.9777/rr.2017.10003 · Cited by 3 · see citing works
Ho, V., Pasquet, R., Luo, S., Chen, G., Goss, P. E., Tu, D., Lazarus, P. J., Richardson, H., & on behalf of the MAP3 Investigators (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05812-1 · Cited by 3 · see citing works
Scaffold attachment factor B1 regulates androgen degradation pathways in prostate cancer.
Yang, J., Chen, Q., You, S., Rotinen, M., Posadas, E. M., Freedland, S. J., Vizio, D. D., Kim, J., & Freeman, M. R. (2021) · Europe PMC (PubMed Central) · Cited by 3 · see citing works
Odermatt, A., & Morris, D. J. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.106954 · Cited by 2 · see citing works
Androgen Glucuronidation in Mice: When, Where, and How
Grosse, L., Chouinard, S., Pâquet, S., Verreault, M., Trottier, J., Bélanger, A., & Barbier, O. (2022) · Biology · doi:10.3390/biology11030403 · Cited by 2 · see citing works
Self-citationTestosterone and epitestosterone differentially regulate UDP-glucuronosyltransferases (UGT) activity
Xiao, L., Qi, J., Zhang, Y., Li, W., 朱亮亮, & Liang, S. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.107058 · Cited by 1 · see citing works
Lee, S.-R., Ahn, M.-H., Choi, Y. H., & Leem, S. (2015) · Genes & Genomics · doi:10.1007/s13258-015-0379-x · Cited by 1 · see citing works
Molecular modeling study of the testosterone metabolizing enzyme UDP-glucuronosyltransferase 2B17
Trane, I., Sager, G., Dietrichs, E. S., & Ravna, A. W. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116060 · Cited by 1 · see citing works
Järvinen, E. (2016) · Työväentutkimus Vuosikirja
Characteristics Of Androgen Metabolism In Prostate Diseases
Roussev, B. H., & Galunska, B. T. (2018) · Varna Medical Forum · doi:10.14748/vmf.v7i2.5137
[Advances in medical therapy of hypertension].
Orbegozo, J. M. R. (1953) · PubMed
The structural basis of conserved residue variant effect on enzyme activity of UGT2B15
Zhang, L., Zhang, X., Yang, Y., Gu, J., Liu, Z., & Wang, C. (2023) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2023.140888
Zid, Z., Gara, S., & Kharrat, M. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4665826
Drug metabolism in cancer patients
Huang, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29289-7.00024-2
Priyadarshi, K., & Rao, T. S. R. B. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45717-3.00008-8
- Authors
- Gauthier-Landry, L., Bélanger, A., & Barbier, O.
- Affiliations
- Université Laval (CA)
- Corresponding author
- Barbier, Olivier
- ORCID
- Barbier, Olivier
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 145
- Pages
- 187-192
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2159660532
- Cited by
- 62
- References
- 82
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 6
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- CIHR
- Natural Sciences and Engineering Research Council of Canada
- Canadian Foundation for Innovation
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- UGT2B15, UGT2B17, UDP-glucuronosyltransferase, androgen metabolism, prostate cancer, androgen receptor, glucuronidation, androgen receptor antagonists, androgen receptor splice variants, prognostic factors, therapeutic target, dehydroepiandrosterone, androstenedione, dihydrotestosterone
- MeSH terms
- Androgens, Gene Expression Regulation, Humans, Male, Prognosis, Prostate, Prostatic Neoplasms, Receptors, Androgen, Glucuronosyltransferase, Minor Histocompatibility Antigens, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Cell Line, Tumor, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review