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Cited by 33Vitamin D Research StudiesBone health and osteoporosis researchVitamin K Research Studies

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Comparison of free and total 25-hydroxyvitamin D in normal human pregnancy

Tsuprykov, Oleg, Buse, Claudia, Skoblo, Roman, Hocher, Berthold·2019·The Journal of Steroid Biochemistry and Molecular Biology
DOI 10.1016/j.jsbmb.2019.03.008
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Abstract

Vitamin D status correct monitoring during pregnancy is critically important for both maternal and fetal health. 25-Hydroxyvitamin D (25(OH)D) - a prohormone of a biologically active 1,25-dihydroxyvitamin D (1,25(OH) 2 D), despite the lack of biological activity, during the past decades has been routinely used as a main biomarker characterizing vitamin D status. About 85% of 25(OH)D in the bloodstream is bound to its specific carrier - vitamin D-binding protein (DBP), the remaining 15% are loosely bound to albumin, and only less than 0.1% are free in the circulation ("free 25(OH)D"). Total 25(OH)D is the sum of DBP-bound, albumin-bound and free 25(OH)D. According to a "free hormone hypothesis", only free 25(OH)D is able to induce a biological effect. Normal pregnancy is characterized by elevated serum DBP levels, and due to this fact the diagnostic strength of serum total 25(OH)D has been questioned. Free 25(OH)D might be a better characteristic of vitamin D status in this settings. We aimed to compare the diagnostic strength of a routine total 25(OH)D with directly measured free 25(OH)D in normal pregnancy by comparing the association strength between free and total 25(OH)D with biomarkers of bone health (PTH, calcium, bone-specific alkaline phosphatase (BSAP)), lipid metabolism (adiponectin, LDL, HDL), kidney function (urea), endocrine parameters (T4, T3, TSH), and group B water-soluble vitamins. The study was conducted in 368 healthy white pregnant women - residents of nor…

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Metadata

Authors
Tsuprykov, O., Buse, C., Skoblo, R., & Hocher, B.
Affiliations
  • NanoTecCenter Weiz Forschungsgesellschaft (Austria) (AT)
  • Hunan Normal University (CN)
Corresponding author
Hocher, Berthold
ORCID
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
2019-06
Volume
190
Pages
29-36
ISSN
0960-0760 (ISSN-L)
DOI
10.1016/j.jsbmb.2019.03.008
OpenAlex
W2922539926
Cited by
33
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 3
FWCI
3.52
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
Keywords
free 25-hydroxyvitamin D, vitamin D status, pregnancy, vitamin D binding protein, free hormone hypothesis, bone metabolism, bone-specific alkaline phosphatase, parathyroid hormone, adiponectin, lipid metabolism, thyroid hormones, water-soluble vitamins, gestational age
MeSH terms
Adult, Female, Gestational Age, Humans, Pregnancy, Protein Binding, Vitamin D, Vitamin D-Binding Protein, Vitamins, Biomarkers, Young Adult

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