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Cited by 332

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

The role of mechanobiology in tendon healing

Open access
Killian, Megan L., Cavinatto, Leonardo, Galatz, Leesa M., Thomopoulos, Stavros·2012·Journal of Shoulder and Elbow Surgery
DOI 10.1016/j.jse.2011.11.002
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Abstract

Mechanical cues affect tendon healing, homeostasis, and development in a variety of settings. Alterations in the mechanical environment are known to result in changes in the expression of extracellular matrix proteins, growth factors, transcription factors, and cytokines that can alter tendon structure and cell viability. Loss of muscle force in utero or in the immediate postnatal period delays tendon and enthesis development. The response of healing tendons to mechanical load varies depending on anatomic location. Flexor tendons require motion to prevent adhesion formation, yet excessive force results in gap formation and subsequent weakening of the repair. Excessive motion in the setting of anterior cruciate ligament reconstruction causes accumulation of macrophages, which are detrimental to tendon graft healing. Complete removal of load is detrimental to rotator cuff healing, yet large forces are also harmful. Controlled loading can enhance healing in most settings; however, a fine balance must be reached between loads that are too low (leading to a catabolic state) and too high (leading to micro-damage). This review will summarize existing knowledge of the mechanobiology of tendon development, homeostasis, and healing.

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Metadata

Authors
Killian, M. L., Cavinatto, L., Galatz, L. M., & Thomopoulos, S.
Venue
Journal of Shoulder and Elbow Surgery
Publisher
Elsevier BV
Published
2012-02
Volume
21
Issue
2
Pages
228-237
ISSN
1058-2746 (ISSN-L)
DOI
10.1016/j.jse.2011.11.002
OpenAlex
W2134851421
Cited by
332
References
92
FWCI
18.96
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The role of mechanobiology in tendon healing. https://app.cochat.ai/papers/10.1016/j.jse.2011.11.002
The paper
Killian, M. L., Cavinatto, L., Galatz, L. M., & Thomopoulos, S. (2012). The role of mechanobiology in tendon healing. Journal of Shoulder and Elbow Surgery. https://doi.org/10.1016/j.jse.2011.11.002

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.