Preventive effect of Metformin against N-nitrosodiethylamine-initiated hepatocellular carcinoma in rats

Estimating the world cancer burden: Globocan 2000

Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2001) · International Journal of Cancer · doi:10.1002/ijc.1440 · Cited by 3,718 · see citing works

Hepatocellular carcinoma

Llovet, J. M., Burroughs, A. K., & Bruix, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14964-1 · Cited by 3,613 · see citing works

Rising Incidence of Hepatocellular Carcinoma in the United States

El‐Serag, H. B., & Mason, A. C. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903113401001 · Cited by 2,865 · see citing works

A Comparison of Lipiodol Chemoembolization and Conservative Treatment for Unresectable Hepatocellular Carcinoma

Hépatocellulaire, G. D. E. D. T. D. C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505113321903 · Cited by 800 · see citing works

Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies

Tapiero, H., Ba, G. N., Couvreur, P., & Tew, K. D. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00193-2 · Cited by 632 · see citing works

Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers

Bartsch, H., Nair, J., & Owen, R. W. (1999) · Carcinogenesis · doi:10.1093/carcin/20.12.2209 · Cited by 481 · see citing works

Metformin: Multi-faceted protection against cancer

Barco, S. D., Vázquez‐Martín, A., Cufí, S., Oliveras‐Ferraros, C., Bosch‐Barrera, J., Joven, J., Martı́n-Castillo, B., & Menéndez, J. A. (2011) · Oncotarget · doi:10.18632/oncotarget.387 · Cited by 302 · see citing works

Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease

Donadon, V., Balbi, M., Mas, M. D., Casarin, P., & Zanette, G. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02223.x · Cited by 293 · see citing works

Metformin and cancer: new applications for an old drug

Kourelis, T., & Siegel, R. D. (2011) · Medical Oncology · doi:10.1007/s12032-011-9846-7 · Cited by 288 · see citing works

Metformin Inhibits Growth of Thyroid Carcinoma Cells, Suppresses Self-Renewal of Derived Cancer Stem Cells, and Potentiates the Effect of Chemotherapeutic Agents

Chen, G., Xu, S., Renko, K., & Derwahl, M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1754 · Cited by 196 · see citing works

Influence of liver cancer on lipid and lipoprotein metabolism

Jiang, J., Nilsson‐Ehle, P., & Xu, N. (2006) · Lipids in Health and Disease · doi:10.1186/1476-511x-5-4 · Cited by 195 · see citing works

The Increasing Incidence of Hepatocellular Carcinoma

Ince, M. N., & Wands, J. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903113401009 · Cited by 192 · see citing works

Impact of Metformin on the Prognosis of Cirrhosis Induced by Viral Hepatitis C in Diabetic Patients

Nkontchou, G., Cosson, E., Aout, M., Mahmoudi, A., Bourcier, V., Charif, I., Ganne‐Carrié, N., Grando–Lemaire, V., Vicaut, É., Trinchet, J., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2415 · Cited by 165 · see citing works

Metformin induces apoptosis of pancreatic cancer cells

Wang, L., Li, Z., Zou, D., Jin, Z., Gao, J., & Xu, G.-M. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.7192 · Cited by 153 · see citing works

Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.

Lucier, G. W., Tritscher, A. M., Goldsworthy, T. L., Foley, J., Clark, G., Goldstein, J. A., & Maronpot, R. R. (1991) · PubMed · Cited by 146 · see citing works

Quality of life is predictive of survival in patients with unresectable hepatocellular carcinoma

Yeo, W., Mo, F. K. F., Koh, J., Chan, A. T. �., Leung, T., Hui, P., Chan, S. L., Tang, A., Lee, J. J., Mok, T. S. K., et al. (2006) · Annals of Oncology · doi:10.1093/annonc/mdl065 · Cited by 122 · see citing works

Effect of metformin on the proliferation, migration, and MMP-2 and-9 expression of human umbilical vein endothelial cells

ESFAHANIAN, N., SHAKIBA, Y., NIKBIN, B., SORAYA, H., MALEKI-DIZAJI, N., GHAZI-KHANSARI, M., & GARJANI, A. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.753 · Cited by 120 · see citing works

Hepatoprotective and anti-hepatocarcinogenic effects of glycyrrhizin and matrine

Wan, X., Luo, M. B., Li, X., et al. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.04.013 · Cited by 118 · see citing works

Protective effect of diphenyl diselenide on acute liver damage induced by 2-nitropropane in rats

Borges, L. P., Borges, V. C., Moro, A. V., Nogueira, C. W., da Rocha, J. B. T., & Zeni, G. R. (2005) · Toxicology · doi:10.1016/j.tox.2005.01.002 · Cited by 97 · see citing works

p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from thailand

Hollstein, M. C., Wild, C. P., Bleicher, F., et al. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910530111 · Cited by 96 · see citing works

Metformin hydrochloride: An antihyperglycemic agent

Klepser, T. B., & Kelly, M. W. (1997) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/54.8.893 · Cited by 83 · see citing works

Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites?

Das, U. N., Madhavi, N., Kumar, G. S., et al. (1998) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(98)90128-4 · Cited by 82 · see citing works

Obesity and insulin resistance in breast cancer – Chemoprevention strategies with a focus on metformin

Goodwin, P. J., & Stambolic, V. (2011) · The Breast · doi:10.1016/s0960-9776(11)70291-0 · Cited by 71 · see citing works

Radical‐induced oxidation of metformin

Khouri, H., Collin, F., Bonnefont‐Rousselot, D., Legrand, A., Jore, D., & Gardès-Albert, M. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04438.x · Cited by 64 · see citing works

Metformin in Noninsulin‐Dependent Diabetes Mellitus

Lee, A. J. (1996) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1996.tb02964.x · Cited by 61 · see citing works

Altered lipid profile, oxidative status and hepatitis B virus interactions in human hepatocellular carcinoma

Abel, S., de Kock, M., Schalkwyk, D. J. V., et al. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.08.003 · Cited by 55 · see citing works

Risk of hepatocellular carcinoma in hepatitis B and prevention through treatment

Carey, W. D., & Sherman, M. (2009) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.76.s3.02 · Cited by 50 · see citing works

Inhibition of P42 MAPK Using A Nonviral Vector-Delivered siRNA Potentiates The Anti-Tumor Effect of Metformin in Prostate Cancer Cells

Monteagudo, S., Pérez‐Martínez, F. C., Pérez‐Carrión, M. D., Guerra, J., Merino, S., Sánchez‐Verdú, P., & Ceña, V. (2011) · Nanomedicine · doi:10.2217/nnm.11.61 · Cited by 46 · see citing works

Anticancer Effects of Metformin and Its Potential Use as a Therapeutic Agent for Breast Cancer

Guppy, A., Jamal‐Hanjani, M., & Pickering, L. M. (2011) · Future Oncology · doi:10.2217/fon.11.49 · Cited by 42 · see citing works

Effect of Semecarpus anacardium nut milk extract on rat serum alpha-fetoprotein level in aflatoxin B1-mediated hepatocellular carcinoma

Premalatha, B., & Sachdanandam, P. (1999) · Fitoterapia · doi:10.1016/s0367-326x(99)00043-x · Cited by 25 · see citing works

Sodium selenite modulates tumour marker indices in N‐nitrosodiethylamine‐initiated and phenobarbital‐promoted rat liver carcinogenesis

Thirunavukkarasu, C., & Sakthisekaran, D. (2003) · Cell Biochemistry and Function · doi:10.1002/cbf.1011 · Cited by 22 · see citing works

Liver cancer is induced by a subnecrogenic dose of DENA when associated with fasting/refeeding: role of glutathione-transferase and lipid peroxidation

Muzio, G., Marengo, B., Salvo, R. A., et al. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00329-3 · Cited by 21 · see citing works

Supplementation of selenium reduces chemical hepatocarcinogenesis in male Sprague-Dawley rats

Alwahaibi, N., Mohamed, J., & Alhamadani, A. (2009) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2009.09.003 · Cited by 21 · see citing works

Therapeutic effects of metformin in breast cancer: involvement of the immune system?

Schott, S., Bierhaus, A., Schütz, F., Beckhove, P., Schneeweiß, A., Sohn, C., & Domschke, C. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1062-y · Cited by 18 · see citing works

Small HCCs Identified by Screening

Pančoška, P., Giorgio, M. D., FAGIUOLI, S., et al. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1687-x · Cited by 10 · see citing works

Small Hepatocellular Carcinoma in Chinese Patients

Carr, B. I., Lu, S., & Pančoška, P. (2011) · Hepatogastroenterology · doi:10.5754/hge11029 · Cited by 9 · see citing works

Epidermal growth factor and glucocorticoid effects on blood prostaglandin E2 level in DENA-induced carcinogenesis

Gönül, B., Söylemezoğlu, T., & Erbaş, D. (1996) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(96)90006-x · Cited by 2 · see citing works

Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity

Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253 · see citing works

Clinical significance analysis of peripheral blood levels of soluble CD147 detection for patients with hyperlipidemia

Zhang, N. (2013) · Laboratory Medicine and Clinic

Study on risk factors of hyperlipidemia

Xie, J. (2000) · Chinese Journal of Disease Control and Prevention

Comparison of plasma lipoprotein profiles and malondialdehyde between hyperlipidemia dogs with/without treatment

Li, G., Kawasumi, K., Okada, Y., et al. (2014) · BMC Veterinary Research · doi:10.1186/1746-6148-10-67 · Cited by 12 · see citing works

Investigation on knowledge of hyperlipidemia in healthy people undergoing medical examination

Lin, Q.-S., Chen, L., Huang, X., et al. (2010) · Central Plains Medical Journal · doi:10.3760/cma.j.issn.1674-4756.2010.14.011

Experimental study of Crateagus pinnatifida on hyperlipidemia prevention and treation

Shi-min, D. (2009) · Chinese Journal of Modern Drug Application · Cited by 1 · see citing works