Metformin Inhibits Growth of Thyroid Carcinoma Cells, Suppresses Self-Renewal of Derived Cancer Stem Cells, and Potentiates the Effect of Chemotherapeutic Agents

Metformin and reduced risk of cancer in diabetic patients

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

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Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

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Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

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Diabetes and cancer

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Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin

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Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

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Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

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The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

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Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes

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The role of insulin receptors and IGF-I receptors in cancer and other diseases

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Cisplatin-Induced Renal Cell Apoptosis: Caspase 3-Dependent and -Independent Pathways

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Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial

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Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

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Estrogen Promotes Growth of Human Thyroid Tumor Cells by Different Molecular Mechanisms1

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Characterization of Side Population in Thyroid Cancer Cell Lines: Cancer Stem-Like Cells Are Enriched Partly But Not Exclusively

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Introducing the Thyroid Gland as Another Victim of the Insulin Resistance Syndrome

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Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis

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The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells

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Estrogen Promotes Growth of Human Thyroid Tumor Cells by Different Molecular Mechanisms

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Increased Prevalence of Insulin Resistance in Patients With Differentiated Thyroid Carcinoma

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Insulin Receptor Isoforms and Insulin-Like Growth Factor Receptor in Human Follicular Cell Precursors from Papillary Thyroid Cancer and Normal Thyroid

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Novel Assay of Metformin Levels in Patients With Type 2 Diabetes and Varying Levels of Renal Function

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Doxorubicin fails to eradicate cancer stem cells derived from anaplastic thyroid carcinoma cells: Characterization of resistant cells

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Stem Cells Derived from Goiters in Adults Form Spheres in Response to Intense Growth Stimulation and Require Thyrotropin for Differentiation into Thyrocytes

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Role of the TSC1-TSC2 Complex in the Integration of Insulin and Glucose Signaling Involved in Pancreatic β-Cell Proliferation

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Highlights of the American Thyroid Association Guidelines for Patients with Thyroid Nodules or Differentiated Thyroid Carcinoma: The 2009 Revision

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Linking Stem Cells to Thyroid Cancer

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Phosphorylated Insulin Like Growth Factor-I Receptor Expression and Its Clinico-Pathological Significance in Histologic Subtypes of Human Thyroid Cancer

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Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16

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Excessive activation of tyrosine kinases leads to inhibition of proliferation in a thyroid carcinoma cell line

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Emerging Therapies in Sight for the Fight against Dedifferentiated Thyroid Cancer

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Cancer metabolism: a therapeutic perspective

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Metformin—mode of action and clinical implications for diabetes and cancer

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Thyroid dysfunction and diabetes mellitus: two closely associated disorders

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Drug repurposing for cancer therapy

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The relationship between type 2 diabetes mellitus and related thyroid diseases

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Metformin Sensitizes EGFR-TKI–Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal

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Sphere-Formation Assay: Three-Dimensional in vitro Culturing of Prostate Cancer Stem/Progenitor Sphere-Forming Cells

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Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing

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Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials

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Metformin selectively affects human glioblastoma tumor-initiating cell viability

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Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells

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The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model

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The Links Between Insulin Resistance, Diabetes, and Cancer

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Links between Thyroid Disorders and Glucose Homeostasis

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Beyond symptomatic relief for chemotherapy‐induced peripheral neuropathy: Targeting the source

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Metformin is synthetically lethal with glucose withdrawal in cancer cells

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Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

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Combination of metformin with chemotherapeutic drugs via different molecular mechanisms

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The association between thyroid cancer and insulin resistance, metabolic syndrome and its components: A systematic review and meta-analysis

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Targeting LKB1 signaling in cancer

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Insulin Resistance: The Increased Risk of Cancers

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Treatment With Metformin Is Associated With Higher Remission Rate in Diabetic Patients With Thyroid Cancer

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Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer

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Metformin inhibits thyroid cancer cell growth, migration, and EMT through the mTOR pathway

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Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells

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Role of Chemokines in Thyroid Cancer Microenvironment: Is CXCL8 the Main Player?

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Mini-Special Issue paper Management of diabetic patients with hypoglycemic agents Metformin and its clinical use: new insights for an old drug in clinical practice

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Oestrogen action on thyroid progenitor cells: relevant for the pathogenesis of thyroid nodules?

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Metformin: The hidden chronicles of a magic drug

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Effect of metabolic syndrome and its components on recurrence and survival in colon cancer patients

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Metformin Reduces Thyroid Cancer Risk in Taiwanese Patients with Type 2 Diabetes

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Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation

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Diabetes mellitus and thyroid diseases

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Cancer Stem Cells: Biological Functions and Therapeutically Targeting

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Metformin and thyroid disease

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Diabetes and Thyroid Cancer Risk: Literature Review

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Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma

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Insulin Resistance: Any Role in the Changing Epidemiology of Thyroid Cancer?

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Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies

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Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines

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The role of an anti-diabetic drug metformin in the treatment of endocrine tumors

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A Novel Dual AMPK Activator/mTOR Inhibitor Inhibits Thyroid Cancer Cell Growth

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Association Between Worse Metabolic Control and Increased Thyroid Volume and Nodular Disease in Elderly Adults with Metabolic Syndrome

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Glucose-deprivation increases thyroid cancer cells sensitivity to metformin

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In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

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Activation of AMPK by metformin promotes renal cancer cell proliferation under glucose deprivation through its interaction with PKM2

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A new appraisal of iodine refractory thyroid cancer

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Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status

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Synergistic anti-proliferative effect of metformin and sorafenib on growth of anaplastic thyroid cancer cells and their stem cells

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Metformin as an Adjuvant Drug against Pediatric Sarcomas: Hypoxia Limits Therapeutic Effects of the Drug

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Metformin and Thyroid: An Update

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p21cip1/waf1 Coordinates Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress

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Therapeutic potential of metformin in papillary thyroid cancer in vitro and in vivo

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1,25 dihydroxyvitamin D3 inhibits the proliferation of thyroid cancer stem-like cells via cell cycle arrest

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Preventive effect of Metformin against N-nitrosodiethylamine-initiated hepatocellular carcinoma in rats

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The Emerging Role of Insulin Receptor Isoforms in Thyroid Cancer: Clinical Implications and New Perspectives

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Diabetes, Diabetes Treatment, and Risk of Thyroid Cancer

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Insulinooporność w chorobach endokrynnych — sposoby terapii

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Protective Effect of Metformin Against Thyroid Cancer Development: A Population-Based Study in Korea

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Dual wavelength irradiation antimicrobial photodynamic therapy using indocyanine green and metformin doped with nano-curcumin as an efficient adjunctive endodontic treatment modality

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Metformin and Cancer Hallmarks: Molecular Mechanisms in Thyroid, Prostate and Head and Neck Cancer Models

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Expression of cancer stem cell markers and epithelial-mesenchymal transition-related factors in anaplastic thyroid carcinoma.

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Repurposing metformin for the treatment of gastrointestinal cancer

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Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery

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Metformin Reverts the Secretion of CXCL8 Induced by TNF-α in Primary Cultures of Human Thyroid Cells: An Additional Indirect Anti-Tumor Effect of the Drug

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Inositol(s) in thyroid function, growth and autoimmunity

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Targeting pancreatic cancer stem cells for cancer therapy

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Mechanisms Linking Obesity and Thyroid Cancer Development and Progression in Mouse Models

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Effects of metformin on the PI3K/AKT/FOXO1 pathway in anaplastic thyroid Cancer cell lines

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Thyroid cancer stem-like cells and epithelial-mesenchymal transition in thyroid cancers

Hardin, H. A., Montemayor, C., & Lloyd, R. V. (2013) · Human Pathology · doi:10.1016/j.humpath.2013.01.009 · Cited by 38 · see citing works

High prevalence of papillary thyroid cancer in Korean women with insulin resistance

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Impact of Metformin and Compound C on NIS Expression and Iodine Uptake In Vitro and In Vivo: A Role for CRE in AMPK Modulation of Thyroid Function

Abdulrahman, R. M., Boon, M. R., Sips, H. C. M., Guigas, B., Rensen, P. C. N., Smit, J. W. A., & Hovens, G. C. (2013) · Thyroid · doi:10.1089/thy.2013.0041 · Cited by 35 · see citing works

Stem Cells and Cancer Stem-Like Cells in Endocrine Tissues

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The Association between Type 2 Diabetes Mellitus and Thyroid Cancer

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Metformin blocks progression of obesity-activated thyroid cancer in a mouse model

Park, J., Kim, W. G., Zhao, L., Enomoto, K., Willingham, M. C., & Cheng, S.-Y. (2016) · Oncotarget · doi:10.18632/oncotarget.8989 · Cited by 33 · see citing works

Role of Metformin in the Treatment of Patients with Thyroid Nodules and Insulin Resistance: A Systematic Review and Meta-Analysis

He, X., Wu, D., Hu, C., Xu, T., Liu, Y., Liu, C., Xu, B., & Tang, W. (2018) · Thyroid · doi:10.1089/thy.2017.0707 · Cited by 33 · see citing works

mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib

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Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo

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Metformin induced lactic acidosis impaired response of cancer cells towards paclitaxel and doxorubicin: Role of monocarboxylate transporter

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Metformin in Differentiated Thyroid Cancer: Molecular Pathways and Its Clinical Implications

García-Sáenz, M. R., Lobaton-Ginsberg, M., & Ferreira‐Hermosillo, A. (2022) · Biomolecules · doi:10.3390/biom12040574 · Cited by 32 · see citing works

The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis

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Metformin inhibits goitrogenous effects of type 2 diabetes

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Hypoxia Increases Thyroid Cancer Stem Cell‐Enriched Side Population

Mahkamova, K., Latar, N. H. M., Aspinall, S. R., & Meeson, A. P. (2017) · World Journal of Surgery · doi:10.1007/s00268-017-4331-x · Cited by 32 · see citing works

Metabolic Reprogramming in Thyroid Cancer

Ju, S. H., Song, M., Lim, J. Y., Kang, Y. E., Yi, H., & Shong, M. (2024) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1802 · Cited by 37 · see citing works

No evidence for a decreased risk of thyroid cancer in association with use of metformin or other antidiabetic drugs: a case-control study

Becker, C., Jick, S. S., Meier, C. R., & Bodmer, M. (2015) · BMC Cancer · doi:10.1186/s12885-015-1719-6 · Cited by 31 · see citing works

Combined Cancer Therapy with Non-Conventional Drugs: All Roads Lead to AMPK

Chen, S., Zhu, X., Lai, X., Xiao, T. L., Wen, A., & Zhang, J. (2014) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557514666140820104444 · Cited by 31 · see citing works

Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β

Bahmad, H. F., Chalhoub, R., Harati, H., Bou-Gharios, J., Assi, S., Ballout, F., Monzer, A., Msheik, H., Araji, T., Elajami, M. K., et al. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00162-7 · Cited by 33 · see citing works

Metformin Is Associated with a Favorable Outcome in Diabetic Patients with Cervical Lymph Node Metastasis of Differentiated Thyroid Cancer

Jang, E. K., Kim, W. G., Kwon, H., Choi, Y. M., Jeon, M. J., Kim, T. Y., Shong, Y. K., Kim, W. B., & Kim, E. Y. (2015) · European Thyroid Journal · doi:10.1159/000437365 · Cited by 31 · see citing works

5′-AMP-Activated Protein Kinase Regulates Papillary (TPC-1 and BCPAP) Thyroid Cancer Cell Survival, Migration, Invasion, and Epithelial-to-Mesenchymal Transition

Cazarin, J., Coelho, R. G., Hecht, F., Andrade, B. M., & de Carvalho, D. P. (2016) · Thyroid · doi:10.1089/thy.2015.0440 · Cited by 31 · see citing works

Concentrations of Selected Adipokines, Interleukin-6, and Vitamin D in Patients with Papillary Thyroid Carcinoma in Respect to Thyroid Cancer Stages

Warakomski, J., Romuk, E. B., Jarząb, B., Krajewska, J., & Siemińśka, L. (2018) · International Journal of Endocrinology · doi:10.1155/2018/4921803 · Cited by 31 · see citing works

Emerging strategies for managing differentiated thyroid cancers refractory to radioiodine

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Sonic Hedgehog Signaling in Thyroid Cancer

Xu, X., Lu, Y., Li, Y., & Prinz, R. A. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00284 · Cited by 30 · see citing works

Insulin resistance in cancer risk and prognosis

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Metformin Synergistically Enhances Antitumor Activity of Histone Deacetylase Inhibitor Trichostatin A Against Osteosarcoma Cell Line

Duo, J., Ma, Y., Wang, G., Han, X., & Zhang, C. (2013) · DNA and Cell Biology · doi:10.1089/dna.2012.1926 · Cited by 29 · see citing works

Epidemiological, Pathophysiological, and Clinical Considerations on the Interplay between Thyroid Disorders and Type 2 Diabetes Mellitus

Grigoriadis, G., Koufakis, T., & Kotsa, K. (2023) · Medicina · doi:10.3390/medicina59112013 · Cited by 32 · see citing works

High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies

Zhao, J., Zhang, Q., Yang, Y., Yao, J., Liao, L., & Dong, J. (2021) · Aging · doi:10.18632/aging.203529 · Cited by 28 · see citing works

Metformin Inhibits Proliferation of Human Thyroid Cancer TPC-1 Cells by Decreasing LRP2 to Suppress the JNK Pathway

He, Y., Cao, L., Wang, L., Liu, L., Huang, Y., & Gong, X. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s227915 · Cited by 28 · see citing works

Effects of prolonged exposure to low dose metformin in thyroid cancer cell lines

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Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers

Teh, J. T., Zhu, W., Newgard, C. B., Casey, P. J., & Wang, M. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0766 · Cited by 27 · see citing works

Thyroid tumor-initiating cells: Increasing evidence and opportunities for anticancer therapy (Review)

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Translational Highlights from The Journal of Clinical Endocrinology & Metabolism

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Effect of metformin on growth of differentiated thyroid cells and thyroid\ncarcinoma cells and their derived cancer stem cells

Chen, G. (2012) · Refubium (Universitätsbibliothek der Freien Universität Berlin)

Effect of metformin on growth of differentiated thyroid cells and thyroid carcinoma cells and their derived cancer stem cells

Chen, G. (2012) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-17583

La metformina inhibe el crecimiento de células de carcinoma de tiroides, suprime la autorrenovación de las células madre del cáncer y potencia el efecto de los agentes quimioterapéuticos

González, D. C. F. (2012) · Revista de Endocrinología y Nutrición

Metformin in Differentiated Thyroid Cancer: Molecular Pathways and Its Clinical Implications

García-Sáenz, M. R., Lobaton-Ginsberg, M., & Ferreira‐Hermosillo, A. (2022) · Biomolecules · doi:10.3390/biom12040574 · Cited by 32 · see citing works