Effect of Plasma Fibrinogen, High-Sensitive C-Reactive Protein, and Cigarette Smoking on Carotid Atherosclerosis: The Suita Study
Open accessAbstract
Background Few studies have reported on the association between inflammatory markers and atherosclerosis by smoking status. We investigated the effect of plasma levels of fibrinogen and high-sensitive C-reactive protein (hsCRP) on subclinical atherosclerosis stratified by smoking in a general urban population.Methods From participants of the Suita study without a history of cardiovascular diseases, a total of 2502 subjects (805 men, median age 64 years) who underwent carotid ultrasonography were enrolled. Subjects were divided into current smokers (n = 566) and never-smokers. Ex-smokers were not included in the study. Each group was subdivided according to the median levels of markers (plasma fibrinogen [2.99 g/L] and hsCRP [.51 mg/L]) and the smoking amounts. We compare the adjusted maximum and mean intima-media thickness (IMT).Results In men and women, maximum IMT and mean IMT of the high fibrinogen and high hsCRP (Fib(H)CRP(H)) with smoking were thicker than those of the low fibrinogen and low hsCRP (Fib(L)CRP(L)) without smoking, the Fib(L)CRP(L) with smoking, and the Fib(H)CRP(H) without smoking after adjusting for covariates. The Fib(L)CRP(L) with smoking had thicker IMTs than the Fib(L)CRP(L) without smoking. There was a dose-dependent smoking effect on IMT in men. These trends were similar in age 60, 65, and 70.Conclusions Plasma fibrinogen and hsCRP levels were related to multivariate-adjusted IMT, and smoking was associated with IMT in men. The combination of plasma fibrinogen and hsCRP levels could be a potential marker on subclinical carotid atherosclerosis in urban people.
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High-sensitive CRP (hs-CRP) has been reported as a possible risk factor for ASCVD.
“However, in recent years, high-sensitive CRP (hs-CRP) has been reported as a possible risk factor for ASCVD278, 279).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [278]
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- Authors
- Kawase Ishihara, K., Kokubo, Y., Yokota, C., Hida, E., Miyata, T., Toyoda, K., Matsumoto, M., Minematsu, K., & Miyamoto, Y.
- Affiliations
- National Cerebral and Cardiovascular Center (JP)
- Hiroshima University Hospital (JP)
- Hiroshima University (JP)
- Corresponding author
- Yokota, Chiaki
- ORCID
- Venue
- Journal of Stroke and Cerebrovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 24
- Issue
- 10
- Pages
- 2385-2389
- ISSN
- 1052-3057 (ISSN-L)
- OpenAlex
- W1797121172
- Cited by
- 32
- References
- 21
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 8 · 2017: 2 · 2016: 3 · 2015: 2
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- Locations
- Journal of Stroke and Cerebrovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- Hiroshima University Acedemic Information Repository (Hiroshima University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Keywords
- fibrinogen, high-sensitivity C-reactive protein, cigarette smoking, carotid atherosclerosis, subclinical atherosclerosis, intima-media thickness, inflammatory markers, urban population
- MeSH terms
- Aged, C-Reactive Protein, Carotid Arteries, Carotid Artery Diseases, Female, Fibrinogen, Humans, Japan, Male, Middle Aged, Smoking, Ultrasonography
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