Associations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP Study
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AIM: To examine whether the inflammatory markers C-reactive protein (CRP) and fibrinogen are associated with biomarkers of atherosclerosis [carotid intima-media thickness (IMT) and coronary artery calcification (CAC)] in the general male population, including Asians. METHODS: Population-based samples of 310 Japanese, 293 Japanese-American and 297 white men 40-49 years of age without clinical cardiovascular disease underwent measurement of IMT, CAC and the CRP and fibrinogen levels as well as other conventional risk factors using standardized methods. Statistical associations between the variables were evaluated using multiple linear or logistic regression models. RESULTS: The Japanese group had significantly lower levels of inflammatory markers and subclinical atherosclerosis than the Japanese-American and white groups (P-values all ＜0.001). The mean level of CRP was 0.66 vs. 1.11 and 1.47 mg/L, while that of fibrinogen was 255.0 vs. 313.0 and 291.5 mg/dl, respectively. In addition, the mean carotid IMT was 0.61 vs. 0.73 and 0.68 mm, while the mean prevalence of CAC was 11.6% vs. 32.1% and 26.3%, respectively. Body mass index (BMI) showed significant positive associations with both the CRP and fibrinogen levels. Although CRP showed a significant positive association with IMT in the Japanese men, this association became non-significant following adjustment for traditional risk factors or BMI. In all three populations, CRP was not found to be significantly associated with the prevalence of CAC. Similarly, fibrinogen did not exhibit a significant association with either IMT or the prevalence of CAC. CONCLUSIONS: The associations between inflammatory markers and subclinical atherosclerosis may merely reflect the strong associations between BMI and the levels of inflammatory markers and incidence of subclinical atherosclerosis in both Eastern and Western populations.
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High levels of fibrinogen and plasminogen activator inhibitor-1 (PAI-1) are markers for ASCVD.
“High levels of fibrinogen and plasminogen activator inhibitor-1 (PAI-1) are markers for ASCVD. (Evidence level: E-1a)”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [299]
Fibrinogen is an independent risk factor for cardiovascular disease.
“Fibrinogen is an independent risk factor for cardiovascular disease297–299).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [299]
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- Authors
- Nagasawa, S.-Y., Ohkubo, T., Masaki, K., Barinas-Mitchell, E., Miura, K., Seto, T., El-Saed, A., Kadowaki, T., Willcox, B. J., Edmundowicz, D., Kadota, A., Evans, R. W., Kadowaki, S., Fujiyoshi, A., Hisamatsu, T., Bertolet, M. H., Okamura, T., Nakamura, Y., Kuller, L. H., Ueshima, H., Sekikawa, A., & ERA-JUNP Study Group
- Affiliations
- Shiga University of Medical Science (JP)
- University of Hawaiʻi at Mānoa (US)
- Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh
- Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, and Kuakini Medical Center
- Temple University (US)
- Osaka Kyoiku University (JP)
- Keio University (JP)
- Kyoto Women's University (JP)
- University of Pittsburgh (US)
- ORCID
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2015
- Volume
- 22
- Issue
- 6
- Pages
- 590-598
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- PMC
- PMC4449327
- OpenAlex
- W1997689068
- Cited by
- 26
- References
- 40
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 10 · 2015: 3
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL068200, R01 HL68200, R01HL071561)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- C-reactive protein, fibrinogen, subclinical atherosclerosis, carotid intima-media thickness, coronary artery calcification, inflammation, body mass index, Japanese men, Japanese-American men, white men, ethnic differences, cardiovascular risk factors
- MeSH terms
- Adult, Asian, C-Reactive Protein, Calcinosis, Coronary Artery Disease, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Fibrinogen, Follow-Up Studies, Humans, Inflammation, Japan, Male, Middle Aged, Prognosis, Risk Factors, United States, Biomarkers, Prevalence, Inflammation Mediators, White People, Asian People, Atherosclerosis, Carotid Intima-Media Thickness
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