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Cited by 21Hormonal and reproductive studiesSexual function and dysfunction studiesMenopause: Health Impacts and Treatments

Demographic and clinical correlates of patient-reported improvement in sex drive, erectile function, and energy with testosterone solution 2

Wu, Frederick, Zitzmann, Michael, Heiselman, Darell, Donatucci, Craig, Knorr, Jack, Patel, Ankur B., Kinchen, Kraig·2016·The Journal of Sexual Medicine
DOI 10.1016/j.jsxm.2016.05.010
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Abstract

INTRODUCTION: Evidence from well-designed studies documenting the benefit of testosterone replacement therapy as a function of patient demographic and clinical characteristics is lacking. AIM: To determine demographic and clinical predictors of treatment outcomes in hypogonadal men with low sex drive, low energy, and/or erectile dysfunction. METHODS: Post hoc analysis of a randomized, multicenter, double-blinded, placebo-controlled, 16-week study of 715 hypogonadal men (mean age = 55.3 years, age range = 19-92 years) presenting with low sex drive and/or low energy who received placebo or testosterone solution 2% for 12 weeks. MAIN OUTCOMES AND MEASURES: Two levels defined patient-reported improvement (PRI) in sex drive or energy: level 1 was at least "a little better" and level 2 was at least "much better" in energy or sex drive on the Patient Global Impression of Improvement at study end point. PRI in erectile function was stratified by erectile dysfunction severity at baseline as measured by the erectile function domain of the International Index for Erectile Function: mild at baseline (change of 2), moderate at baseline (change of 5), and severe at baseline (change of 7). Associations of demographic and clinical characteristics with PRI were calculated with stepwise forward multiple logistic regression analysis. Odds ratios represented the likelihood of PRI in symptoms among variable categories. RESULTS: Higher levels of end-point testosterone were associated with higher rates of PRI (at levels 1 and 2) in sex drive and energy (P < .001 for the two comparisons). Lower baseline testosterone levels were associated with higher rates of level 1 PRI in sex drive (P = .028); and classic hypogonadism (vs non-classic hypogonadism) was associated with higher rates of level 2 PRI in sex drive (P = .005) and energy (P = .006). CONCLUSION: When assessing the potential for improvements in men with testosterone deficiency using patient-reported outcome questionnaires, possible predictors of treatment outcomes to consider include the etiology of hypogonadism and testosterone levels (baseline and end point).

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  • The suppression of the HPT axis in functional hypogonadism associated with obesity is considered to be an adaptive response to weight variation.

    “The suppression of HPT axis in FH associated with obesity is considered to be an adaptive response to the weight variation (25).”

    From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [25]

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Authors
Wu, F., Zitzmann, M., Heiselman, D., Donatucci, C., Knorr, J., Patel, A. B., & Kinchen, K.
Affiliations
  • University of Manchester (GB)
  • University of Münster (DE)
  • Eli Lilly (United States) (US)
Corresponding author
Wu, Frederick
ORCID
Venue
The Journal of Sexual Medicine
Publisher
Oxford University Press (OUP)
Published
2016-08-01
Volume
13
Issue
8
Pages
1212-1219
ISSN
  • 1743-6095 (ISSN-L)
  • 1743-6109
DOI
10.1016/j.jsxm.2016.05.010
OpenAlex
W2426501269
Cited by
21
References
15
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 1
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Sexual Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
Funders
Eli Lilly and Company
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
testosterone replacement therapy, hypogonadism, erectile dysfunction, low energy, patient-reported outcomes, predictors of treatment response, International Index of Erectile Function
MeSH terms
Patient Reported Outcome Measures, Adult, Aged, Aged, 80 and over, Androgens, Demography, Double-Blind Method, Humans, Hypogonadism, Erectile Dysfunction, Libido, Male, Middle Aged, Penile Erection, Quality of Life, Surveys and Questionnaires, Testosterone, Treatment Outcome, Young Adult

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