The efficacy and adverse events of testosterone replacement therapy in hypogonadal men: A systematic review and meta-analysis of randomized, placebo-controlled trials
Abstract
CONTEXT: The efficacy and safety of testosterone replacement therapy (TRT) in hypogonadal men remain incompletely understood. OBJECTIVE: To conduct a systematic review and meta-analysis of randomized clinical trials (RCT) to determine the effects of TRT on patient-important outcomes and adverse events in hypogonadal men. DATA SOURCES: We searched Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Database of Systematic Reviews, Ovid Cochrane Central Register of Controlled Trials, and Scopus from inception to March 2th, 2017. STUDY SELECTION: RCTs that assessed the efficacy and adverse events of TRT of at least 12 weeks compared with placebo in adult men with hypogonadism, defined by morning testosterone ≤300 ng/dL and at least one symptom or sign of hypogonadism. DATA EXTRACTION: Reviewers working independently and in duplicate assessed the quality of the trials and collected data on patient characteristics, interventions, and outcomes. DATA SYNTHESIS: We found 11 publications, reporting on 4 eligible trials (including 1,779 patients) at low risk of bias. Compared to placebo, TRT was associated with a small but significant increase in sexual desire or libido [standardized mean difference (SMD): 0.17, 95% CI 0.01, 0.34] (n=1383), erectile function [SMD: 0.16, 95% CI 0.06, 0.27] (n=1344), and sexual satisfaction [SMD: 0.16, 95% CI 0.01, 0.31] (n=676), but had no effect on energy or mood. TRT was associated with an increased risk of developing erythrocytosis [relative risk: 8.14, 95% CI: 1.87, 35.40] (n=1579) compared to placebo, but had no significant effect on lower urinary tract symptoms (LUTS). CONCLUSION: In hypogonadal men TRT improves sexual desire, erectile function, and sexual satisfaction, however it increases the risk of erythrocytosis.
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The prevalence of functional hypogonadism in the obese male population is increased by 13-fold.
“Despite the fact that the prevalence of FH in obese male population is increased by 13-fold (8), the impact of liraglutide on obesity-related FH has not yet been addressed in a prospective clinical study.”
From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [8]
LH increased with weight reduction in a magnitude-dependent manner.
“It has been reported previously that LH increased with WR in magnitude-dependent manner (8).”
From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [8]
With weight loss of more than 15%, LH increased by 2.2 IU.
“With weight loss of more than 15% LH increased for 2.2 IU (8).”
From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [8]
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,588 · see citing works
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,406 · see citing works
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., & Mishra, A. (1997) · Urology · doi:10.1016/s0090-4295(97)00238-0 · Cited by 5,849 · see citing works
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2354 · Cited by 1,954 · see citing works
Self-citationEffects of Testosterone Treatment in Older Men
Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., Gill, T. M., Barrett-Connor, E., Swerdloff, R. S., Wang, C., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1506119 · Cited by 890 · see citing works
Self-citationCalof, O. M., Singh, A. B., Lee, M. L., Kenny, A. M., Urban, R. J., Tenover, J. L., & Bhasin, S. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.11.1451 · Cited by 728 · see citing works
Self-citationAdverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis
Fernández-Balsells, M. M., Murad, M. H., Lane, M., Lampropulos, J. F., Albuquerque, F., Mullan, R. J., Agrwal, N., Elamin, M. B., Gallegos-Orozco, J. F., Wang, A. T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2575 · Cited by 713 · see citing works
Self-citationAssessment of Memory Complaint in Age-Associated Memory Impairment: The MAC-Q
Crook, T. H., Feher, E. P., & Larrabee, G. J. (1992) · International Psychogeriatrics · doi:10.1017/s1041610292000991 · Cited by 434 · see citing works
Steidle, C. P., Schwartz, S. L., Jacoby, K., Sebree, T. B., Smith, T. P. L., & Bachand, R. T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021058 · Cited by 406 · see citing works
Snyder, P. J., Kopperdahl, D. L., Stephens-Shields, A. J., Ellenberg, S. S., Cauley, J. A., Ensrud, K. E., Lewis, C. E., Barrett-Connor, E., Schwartz, A. V., Lee, D. C., et al. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.9539 · Cited by 363 · see citing works
Self-citationTestosterone supplementation and sexual function: A meta-analysis study
Corona, G., Isidori, A. M., Buvat, J., Aversa, A., Rastrelli, G., Hackett, G., Rochira, V., Sforza, A., Lenzi, A., Mannucci, E., et al. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12536 · Cited by 263 · see citing works
Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial
Roy, C. N., Snyder, P. J., Stephens-Shields, A. J., Artz, A. S., Bhasin, S., Cohen, H. J., Farrar, J. T., Gill, T. M., Zeldow, B., Cella, D., et al. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.9540 · Cited by 239 · see citing works
Self-citationCorona, G., Rastrelli, G., Morgentaler, A., Sforza, A., Mannucci, E., & Maggi, M. (2017) · European Urology · doi:10.1016/j.eururo.2017.03.032 · Cited by 225 · see citing works
Resnick, S. M., Matsumoto, A. M., Stephens-Shields, A. J., Ellenberg, S. S., Gill, T. M., Shumaker, S. A., Pleasants, D. D., Barrett-Connor, E., Bhasin, S., Cauley, J. A., et al. (2017) · JAMA · doi:10.1001/jama.2016.21044 · Cited by 220 · see citing works
Self-citationTestosterone Therapy and Cardiovascular Risk: Advances and Controversies
Morgentaler, A., Miner, M. M., Caliber, M., Guay, A. T., Khera, M., & Traish, A. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.10.011 · Cited by 211 · see citing works
Boloña, E. R., Uraga, M. V., Haddad, R. M., Tracz, M. J., Sideras, K., Kennedy, C. C., Caples, S. M., Erwin, P. J., & Montori, V. M. (2007) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)60963-4 · Cited by 184 · see citing works
Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels
Cunningham, G. R., Stephens-Shields, A. J., Rosen, R. C., Wang, C., Bhasin, S., Matsumoto, A. M., Parsons, J. K., Gill, T. M., Molitch, M. E., Farrar, J. T., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1645 · Cited by 162 · see citing works
Self-citationBrock, G., Heiselman, D., Maggi, M., Kim, S. W., Rodríguez Vallejo, J. M., Behre, H. M., McGettigan, J., Dowsett, S. A., Hayes, R. P., Knorr, J., et al. (2016) · Journal of Urology · doi:10.1016/j.juro.2015.10.083 · Cited by 109 · see citing works
Seftel, A. D., Mack, R. J., Secrest, A. R., & Smith, T. M. (2004) · Journal of Andrology · doi:10.1002/j.1939-4640.2004.tb03169.x · Cited by 108 · see citing works
2016 Update on Medical Overuse: A Systematic Review
Morgan, D. J., Dhruva, S. S., Wright, S. M., & Korenstein, D. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.5381 · Cited by 104 · see citing works
Treatment of Men for “Low Testosterone”: A Systematic Review
Huo, S., Scialli, A. R., McGarvey, S., Hill, E., Tügertimur, B., Hogenmiller, A., Hirsch, A. I., & Fugh-Berman, A. (2016) · PLOS ONE · doi:10.1371/journal.pone.0162480 · Cited by 97 · see citing works
Kohn, T. P., Mata, D. A., Ramasamy, R., & Lipshultz, L. I. (2016) · European Urology · doi:10.1016/j.eururo.2016.01.043 · Cited by 83 · see citing works
Paduch, D. A., Polzer, P. K., Ni, X., & Basaria, S. S. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4434 · Cited by 73 · see citing works
Effects of Testosterone Therapy on Cognitive Function in Aging: A Systematic Review
Hua, J. T., Hildreth, K. L., & Pelak, V. S. (2016) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000104 · Cited by 67 · see citing works
A Simple Self‐Report Diary for Assessing Psychosexual Function in Hypogonadal Men
Lee, K. K., Berman, N., Alexander, G. M., Hull, L., Swerdloff, R. S., & Wang, C. (2003) · Journal of Andrology · doi:10.1002/j.1939-4640.2003.tb02728.x · Cited by 63 · see citing works
Screening and Monitoring in Men Prescribed Testosterone Therapy in the U.S., 2001–2010
Baillargeon, J., Urban, R. J., Kuo, Y.-F., Holmes, H. M., Raji, M. A., Morgentaler, A., Howrey, B. T., Lin, Y.-L., & Ottenbacher, K. J. (2015) · Public Health Reports® · doi:10.1177/003335491513000207 · Cited by 61 · see citing works
Late-onset hypogonadism in the aging male (LOH): definition, diagnostic and clinical aspects.
Schubert, M., & Jockenhövel, F. (2005) · PubMed · Cited by 56 · see citing works
Guo, C., Gu, W., Liu, M., Peng, B., Yao, X., Yang, B., & Zheng, J. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2957 · Cited by 51 · see citing works
Ascertainment of Testosterone Prescribing Practices in the VA
Jasuja, G. K., Bhasin, S., Reisman, J. I., Berlowitz, D. R., & Rose, A. J. (2015) · Medical Care · doi:10.1097/mlr.0000000000000398 · Cited by 51 · see citing works
Self-citationMarketing and Testosterone Treatment in the USA: A Systematic Review
Bandari, J., Ayyash, O. M., Emery, S., Wessel, C. B., & Davies, B. J. (2017) · European Urology Focus · doi:10.1016/j.euf.2017.10.016 · Cited by 51 · see citing works
Nian, Y., Ding, M., Hu, S., He, H., Cheng, S., Yi, L., Li, Y., & Wang, Y. (2016) · Andrologia · doi:10.1111/and.12630 · Cited by 36 · see citing works
Wu, F., Zitzmann, M., Heiselman, D., Donatucci, C., Knorr, J., Patel, A. B., & Kinchen, K. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.05.010 · Cited by 21 · see citing works
Impact of Testosterone Solution 2% on Ejaculatory Dysfunction in Hypogonadal Men
Maggi, M., Heiselman, D., Knorr, J., Iyengar, S., Paduch, D. A., & Donatucci, C. F. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.05.012 · Cited by 21 · see citing works
Gelhorn, H. L., Vernon, M., Stewart, K. D., Miller, M. G., Brod, M. I., Althof, S. E., Derogatis, L. R., Dobs, A. S., Seftel, A. D., & Revicki, D. A. (2015) · Patient · doi:10.1007/s40271-015-0138-8 · Cited by 13 · see citing works
Hayes, R. P., Ni, X., Heiselman, D., & Kinchen, K. (2016) · International Journal of Clinical Practice · doi:10.1111/ijcp.12828 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Cited by
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Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
Bhasin, S., Brito, J. P., Cunningham, G. R., Hayes, F. J., Hodis, H. N., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., Wu, F. C., & Yialamas, M. A. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00229 · Cited by 1,736 · see citing works
Self-citationCorona, G., Goulis, D. G., Huhtaniemi, I., Zitzmann, M., Toppari, J., Forti, G., Vanderschueren, D., & Wu, F. C. (2020) · Andrology · doi:10.1111/andr.12770 · Cited by 431 · see citing works
Paediatric and adult-onset male hypogonadism
Salonia, A., Rastrelli, G., Hackett, G., Seminara, S. B., Huhtaniemi, I. T., Rey, R. A., Hellstrom, W. J. G., Palmert, M. R., Corona, G., Dohle, G. R., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0087-y · Cited by 286 · see citing works
Testosterone replacement therapy
Barbonetti, A., D’Andrea, S., & Francavilla, S. (2020) · Andrology · doi:10.1111/andr.12774 · Cited by 168 · see citing works
Isidori, A. M., Aversa, A., Calogero, A. E., Ferlin, A., Francavilla, S., Lanfranco, F., Pivonello, R., Rochira, V., Corona, G., & Maggi, M. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01859-7 · Cited by 162 · see citing works
Aging and the Male Reproductive System
Kaufman, J., Lapauw, B., Mahmoud, A., T'Sjoen, G. G., & Huhtaniemi, I. T. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00178 · Cited by 145 · see citing works
Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism
Jayasena, C. N., Anderson, R. A., Llahana, S., Barth, J. H., MacKenzie, F., Wilkes, S., Smith, N., Sooriakumaran, P., Minhas, S., Wu, F. C. W., et al. (2022) · Clinical Endocrinology · doi:10.1111/cen.14633 · Cited by 147 · see citing works
Allen, M. S., & Walter, E. E. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.01.314 · Cited by 116 · see citing works
Sex and Gender Differences in Prevention of Type 2 Diabetes
Harreiter, J., & Kautzky‐Willer, A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00220 · Cited by 120 · see citing works
Effects of liraglutide on obesity-associated functional hypogonadism in men
Jensterle, M., Podbregar, A., Goricar, K., Gregoric, N., & Janez, A. (2019) · Endocrine Connections · doi:10.1530/ec-18-0514 · Cited by 101 · see citing works
Kasman, A. M., Del Giudice, F., & Eisenberg, M. L. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.01.002 · Cited by 94 · see citing works
Giudice, F. D., Kasman, A. M., Ferro, M., Sciarra, A., BERARDINIS, E. D., Belladelli, F., Salonia, A., & Eisenberg, M. L. (2020) · Korean journal of urology · doi:10.4111/icu.2020.61.4.355 · Cited by 96 · see citing works
Pencina, K. M., Travison, T. G., Cunningham, G. R., Lincoff, A. M., Nissen, S. E., Khera, M., Miller, M. G., Flevaris, P., Li, X., Wannemuehler, K. A., et al. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad484 · Cited by 98 · see citing works
Self-citationProstate Safety Events During Testosterone Replacement Therapy in Men With Hypogonadism
Bhasin, S., Travison, T. G., Pencina, K. M., O’Leary, M. P., Cunningham, G. R., Lincoff, A. M., Nissen, S. E., Lucia, M. S., Preston, M. A., Khera, M., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.48692 · Cited by 76 · see citing works
Self-citationDiem, S. J., Greer, N. L., MacDonald, R. H., McKenzie, L. G., Dahm, P., Ercan-Fang, N. G., Estrada, A., Hemmy, L. S., Rosebush, C. E., Fink, H. A., et al. (2020) · Annals of Internal Medicine · doi:10.7326/m19-0830 · Cited by 72 · see citing works
The complex association between metabolic syndrome and male hypogonadism
Dimopoulou, C., Goulis, D. G., Corona, G., & Maggi, M. (2018) · Metabolism · doi:10.1016/j.metabol.2018.03.024 · Cited by 62 · see citing works
Anabolic-Androgenic Steroid Use in Sports, Health, and Society
Bhasin, S., Hatfield, D. L., Hoffman, J. R., Kraemer, W. J., LaBotz, M., Phillips, S. M., & Ratamess, N. A. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002670 · Cited by 60 · see citing works
Self-citationEndocrine treatment of aging transgender people
Gooren, L. J., & T'Sjoen, G. G. (2018) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-018-9449-0 · Cited by 55 · see citing works
Testosterone Replacement Therapy for Sexual Symptoms
Rastrelli, G., Guaraldi, F., Reismann, Y., Sforza, A., Isidori, A. M., Maggi, M., & Corona, G. (2019) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2018.11.005 · Cited by 54 · see citing works
Providing Care for Transgender Persons With Kidney Disease: A Narrative Review
Collister, D., Saad, N., Christie, E. A., & Ahmed, S. B. (2021) · Canadian Journal of Kidney Health and Disease · doi:10.1177/2054358120985379 · Cited by 52 · see citing works
Haematological actions of androgens
Warren, A. M., & Grossmann, M. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101653 · Cited by 49 · see citing works
Zhang, H., Basit, A., Busch, D., Yabut, K. C. B., Bhatt, D. K., Droździk, M., Ostrowski, M., Li, A. P., Collins, C. J., Oswald, S., et al. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.08.003 · Cited by 48 · see citing works
Kim, S. H., Park, J. J., Kim, K. H., Yang, H. J., Kim, D. S., Lee, C. H., Jeon, Y. S., Shim, S. R., & Kim, J. H. (2021) · International Urology and Nephrology · doi:10.1007/s11255-021-02876-w · Cited by 47 · see citing works
Androgens and male sexual function
Corona, G., Rastrelli, G., Vignozzi, L., & Maggi, M. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101615 · Cited by 50 · see citing works
Hackett, G. I., Cole, N., Mulay, A., Strange, R. C., & Ramachandran, S. (2018) · British Journal of Urology · doi:10.1111/bju.14536 · Cited by 43 · see citing works
Yeap, B. B., & Wu, F. C. W. (2018) · Clinical Endocrinology · doi:10.1111/cen.13888 · Cited by 44 · see citing works
Gray, P. B., Straftis, A. A., Bird, B. M., McHale, T. S., & Zilioli, S. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.04.017 · Cited by 45 · see citing works
Ågmo, A., & Laan, E. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104595 · Cited by 42 · see citing works
Testosterone Therapy With Subcutaneous Injections: A Safe, Practical, and Reasonable Option
Figueiredo, M. G., Gagliano‐Jucá, T., & Basaria, S. S. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab772 · Cited by 41 · see citing works
Type 2 Diabetes and Testosterone Therapy
Hackett, G. I. (2018) · The World Journal of Men s Health · doi:10.5534/wjmh.180027 · Cited by 39 · see citing works
Gagliano‐Jucá, T., Pencina, K. M., Guo, W., Li, Z., Huang, G. T.-W., Basaria, S. S., & Bhasin, S. (2020) · Andrology · doi:10.1111/andr.12834 · Cited by 40 · see citing works
Self-citationPhysical activity as an adjunct treatment for erectile dysfunction
Allen, M. S. (2019) · Nature Reviews Urology · doi:10.1038/s41585-019-0210-6 · Cited by 38 · see citing works
Bhasin, S., Krishnan, V., Storer, T. W., Steiner, M., & Dobs, A. S. (2023) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glad027 · Cited by 36 · see citing works
Self-citationAllen, M. S., & Tostes, R. C. (2023) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeac007 · Cited by 34 · see citing works
Hackett, G. I., Cole, N., Mulay, A., Strange, R. C., & Ramachandran, S. (2018) · The World Journal of Men s Health · doi:10.5534/wjmh.180052m · Cited by 31 · see citing works
EMAS position statement: Testosterone replacement therapy in older men
Kanakis, G., Pofi, R., Goulis, D. G., Isidori, A. M., Armeni, E., Erel, C. T., Fistonić, I., Hillard, T., Hirschberg, A. L., Męczekalski, B., et al. (2023) · Maturitas · doi:10.1016/j.maturitas.2023.107854 · Cited by 32 · see citing works
Endosialin defines human stem Leydig cells with regenerative potential
Xia, K., Ma, Y., Feng, X. G., Deng, R., Ke, Q., Xiang, A. P., & Deng, C. (2020) · Human Reproduction · doi:10.1093/humrep/deaa174 · Cited by 28 · see citing works
Testosterone replacement in aging men: an evidence-based patient-centric perspective
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Self-citationA Selective Androgen Receptor Modulator (OPK-88004) in Prostate Cancer Survivors: A Randomized Trial
Pencina, K. M., Burnett, A. L. “., Storer, T. W., Guo, W., Li, Z., Kibel, A. S., Huang, G. T.-W., Blouin, M., Berry, D. L., Basaria, S. S., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab361 · Cited by 27 · see citing works
Self-citationTestosterone Treatment in Middle-Aged and Older Men with Hypogonadism
Bhasin, S., & Snyder, P. J. (2025) · New England Journal of Medicine · doi:10.1056/nejmra2404637 · Cited by 27 · see citing works
Self-citationObstructive Sleep Apnea and Testosterone Therapy
Payne, K. S., Lipshultz, L. I., Hotaling, J. M., & Pastuszak, A. W. (2020) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2020.04.004 · Cited by 25 · see citing works
Graybill, S. D., Hatfield, J., Kravchenko, M. I., Beckman, D., Tate, J. M., Beauvais, A., CLERC, P. G., Davila, D., Forbes, W. L., Wardian, J., et al. (2021) · Andrology · doi:10.1111/andr.12966 · Cited by 38 · see citing works
Grossmann, M., Jayasena, C. N., & Anawalt, B. D. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad180 · Cited by 25 · see citing works
Hyperprolactinemia and male sexual function: focus on erectile dysfunction and sexual desire
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Grunwald, E., Kreiberg, M., Dehlendorff, C., Jørgensen, N., Juul, A., Lauritsen, J., Wagner, T., Rosenvilde, J. J., Daugaard, G., & Bandak, M. (2022) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2022.03.012 · Cited by 22 · see citing works
Hepcidin is not essential for mediating testosterone's effects on erythropoiesis
Guo, W., Schmidt, P. J., Fleming, M. D., & Bhasin, S. (2019) · Andrology · doi:10.1111/andr.12622 · Cited by 21 · see citing works
Self-citationTranscription regulation of NRF1 on StAR reduces testosterone synthesis in hypoxemic murine
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Endocrine Outcomes After Pituitary Surgery
Buttan, A. K., & Mamelak, A. N. (2019) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2019.05.009 · Cited by 21 · see citing works
Testosterone replacement in men with sexual dysfunction
Lee, H., Hwang, E. C., Oh, C. K., Lee, S., Yu, H. S., Lim, J. S., Kim, H. W., Walsh, T. J., Kim, M. H., Jung, J. H., et al. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013071.pub2 · Cited by 20 · see citing works
Izumi, K., Iwamoto, H., Yaegashi, H., Nohara, T., Shigehara, K., Kadono, Y., Nanjo, S., Yamada, T., Ohtsubo, K., Yano, S., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12716 · Cited by 19 · see citing works
Moser, V., Christensen, A., Liu, J., Zhou, A.-J., Yagi, S., Beam, C. R., Galea, L., & Pike, C. J. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.016 · Cited by 19 · see citing works
Marcelli, M., & Mediwala, S. N. (2020) · Journal of Investigative Medicine · doi:10.1136/jim-2019-001233 · Cited by 20 · see citing works
Testosterone therapy in older men: clinical implications of recent landmark trials
Grossmann, M., Anawalt, B. D., & Yeap, B. B. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae071 · Cited by 18 · see citing works
Straftis, A. A., & Gray, P. B. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16183261 · Cited by 18 · see citing works
Phelan, R., Im, A., Hunter, R. L., Inamoto, Y., Stanghellini, M. T. L., Rovó, A., Badawy, S. M., Burns, L. J., Eissa, H., Murthy, H. S., et al. (2021) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2021.10.013 · Cited by 17 · see citing works
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Bhasin, S., & Thompson, I. M. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae334 · Cited by 17 · see citing works
Self-citationMaggi, M., Filippi, S., Vignozzi, L., & Rastrelli, G. (2020) · Andrology · doi:10.1111/andr.12794 · Cited by 17 · see citing works
Erythrocytosis in Gender-Affirming Care With Testosterone
Porat, A. T., Ellwood, M., Rodina, M., & Dianat, S. (2023) · The Annals of Family Medicine · doi:10.1370/afm.3018 · Cited by 16 · see citing works
Phelan, R., Im, A., Hunter, R. L., Inamoto, Y., Stanghellini, M. T. L., Rovó, A., Badawy, S. M., Burns, L. J., Eissa, H., Murthy, H. S., et al. (2022) · Bone Marrow Transplantation · doi:10.1038/s41409-022-01591-z · Cited by 15 · see citing works
Testosterone treatment of late-onset hypogonadism – benefits and risks
Snyder, P. J. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09712-1 · Cited by 15 · see citing works
Liu, W., Du, L., Cui, Y., He, C., & He, Z. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05077-z · Cited by 14 · see citing works
Optimizing Diagnostic Accuracy and Treatment Decisions in Men With Testosterone Deficiency
Bhasin, S., & Ozimek, N. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.08.002 · Cited by 15 · see citing works
Self-citationFalqueto, H., dos Santos, M. R., & Manfredi, L. H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.838526 · Cited by 15 · see citing works
Benefits and Risks of Testosterone Treatment of Older Men with Hypogonadism
Galbiati, F., Goldman, A. L., Gattu, A. K., Guzelce, E. C., & Bhasin, S. (2022) · Urologic Clinics of North America · doi:10.1016/j.ucl.2022.07.011 · Cited by 14 · see citing works
Self-citationGrossmann, M., Robledo, K. P., Daniel, M., Handelsman, D. J., Inder, W. J., Stuckey, B. G. A., Yeap, B. B., Fui, M. N. T., Bracken, K., Allan, C. A., et al. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae085 · Cited by 13 · see citing works
Zhou, J., Hou, Y., Zhang, Z., Xing, X., Zou, X., Zhong, L., Huang, H., Zhang, Z., & Sun, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.178 · Cited by 13 · see citing works
El‐Khatib, F. M., Huynh, L. M., Kopelevich, A., Osman, M. M., Choi, E. J., Nguyen, J., Dianatnejad, S., Wu, Q., Olivas, M., Spitz, A., et al. (2021) · International Journal of Impotence Research · doi:10.1038/s41443-021-00449-0 · Cited by 12 · see citing works
Novaes, M. T., de Carvalho, O. L. F., Ferreira, P. H. G., Tiraboschi, T. L. N., Silva, C. S., Contreras, J. C. Z., Gomes, C. M., Miranda, E., Júnior, O. A. D. C., & de Bessa, J. (2021) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2021.100538 · Cited by 12 · see citing works
Kazmerski, T. M., Stransky, O. M., Lavage, D. R., Hughan, K. S., Jain, R., Ladores, S., Stalvey, M. S., Tangpricha, V., Taylor‐Cousar, J. L., West, N. E., et al. (2023) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2023.10.023 · Cited by 11 · see citing works
Disorders of Puberty: Pharmacotherapeutic Strategies for Management
Zacharin, M. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_208 · Cited by 11 · see citing works
Pallotti, F., Senofonte, G., Conflitti, A. C., Giancotti, A., Anzuini, A., Paoli, E. D., Chiano, S. D., Faja, F., Gatta, V., Mondo, A., et al. (2023) · Endocrine · doi:10.1007/s12020-023-03421-8 · Cited by 11 · see citing works
Zhong, S.-R., Yang, H.-H., Liao, C.-H., Yang, D., Tu, S.-K., Hung, C.-L., & Liao, C. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s282832 · Cited by 11 · see citing works
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Collister, D., Krakowsky, Y., Potter, E., & Millar, A. C. (2022) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2022.04.004 · Cited by 11 · see citing works
Anawalt, B. D., O’Connor, K., & Grossmann, M. (2026) · JAMA · doi:10.1001/jama.2026.8526 · Cited by 11 · see citing works
Primary and Secondary Hypogonadism in Male Persons with Diabetes Mellitus
Martins, J. M., Jorge, M. D. P., Maia, C. M., Roque, J., Lemos, C., Nunes, D., Reis, D., & Mota, C. (2021) · International Journal of Endocrinology · doi:10.1155/2021/8799537 · Cited by 10 · see citing works
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Grossmann, M., & Jones, T. H. (2021) · European Journal of Endocrinology · doi:10.1530/eje-21-0362 · Cited by 10 · see citing works
Rastrelli, G., Antonio, L., Carrier, S., Isidori, A. M., & Maggi, M. (2025) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeaf025 · Cited by 9 · see citing works
Identifying the outcomes important to men with hypogonadism: A qualitative evidence synthesis
Aceves‐Martins, M., Quinton, R., Brazzelli, M. G., Cruickshank, M., Manson, P. D., Hudson, J., Oliver, N. S., Hernández, R. A., Aucott, L. S., Wu, F. C. W., et al. (2022) · Andrology · doi:10.1111/andr.13156 · Cited by 9 · see citing works
Rivero, M., Ory, J., Diaz, P., Thirumavalavan, N., Han, S., dos Reis, I. M., & Ramasamy, R. (2023) · The Journal of Urology · doi:10.1097/ju.0000000000003487 · Cited by 9 · see citing works
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Matsumoto, A. M. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.001 · Cited by 9 · see citing works
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Gulve, R. M., B., D. R., Phatake, Y. B., & R., D. S. (2019) · Journal of Experimental Biology and Agricultural Sciences · doi:10.18006/2019.7(5).494.504 · Cited by 8 · see citing works
Carmichael, O. T., Pillai, S. R., Murray, K. B., Shankapal, P., Caldwell, J. A., Vartanian, O. A., Berryman, C. E., Karl, J. P., Harris, M. N., Rood, J. C., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118496 · Cited by 8 · see citing works
The anabolic applications of androgens in older adults with functional limitations
Gattu, A. K., Goldman, A. L., Guzelce, E. C., Galbiati, F., & Bhasin, S. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09766-1 · Cited by 8 · see citing works
Self-citationNeidhart, A., von Wyl, V., Käslin, B., Henzen, C., & Fischli, S. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1496906 · Cited by 7 · see citing works
Interplay between male gonadal function and overall male health
Asero, V., Scornajenghi, C. M., Iaconis, S., Sicignano, E., Falcone, A., Dinacci, F., Pagano, G., Carino, D., Corvino, R., & Tresh, A. S. (2024) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2024-0054 · Cited by 6 · see citing works
Pharmacological targeting of age-related changes in skeletal muscle tissue
Leuchtmann, A. B., & Handschin, C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.030 · Cited by 6 · see citing works
Panizzon, M. S., Bree, K. K., Hsieh, T., Hauger, R. L., Xian, H., Jacobson, K. C., Lyons, M. J., & Franz, C. E. (2020) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2020.08.016 · Cited by 6 · see citing works
The Effects of Testosterone Treatment on Cardiovascular Health
Jayasena, C. N., Ho, C. L. T., & Bhasin, S. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.006 · Cited by 6 · see citing works
Self-citationZolla, L., & Ceci, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031916 · Cited by 6 · see citing works
Sexual Dysfunction in Chronic Kidney Disease
Johansen, K. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815876-0.00037-1 · Cited by 6 · see citing works
Andropause: A Neglected Disease Entity
Ajayi, A. F., David, O. T., Ayodele, A. A., Oluwatoyin, A. L., Obukohwo, O. M., Oyedokun, P. A., Akanbi, G. B., Nene, D. S., & Magret, A. A. (2024) · OBM Geriatrics · doi:10.21926/obm.geriatr.2402276 · Cited by 7 · see citing works
Cardiovascular disease and testosterone therapy in male hypogonadism
de Silva, N. L., Grant, B., Minhas, S., & Jayasena, C. N. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15211 · Cited by 6 · see citing works
Wu, F. C. W. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101626 · Cited by 5 · see citing works
New Horizons: Testosterone or Exercise for Cardiometabolic Health in Older Men
GREEN, D. J., Chasland, L. C., Naylor, L. H., & Yeap, B. B. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad175 · Cited by 5 · see citing works
Quang, L. M., & Kalhan, A. (2018) · British Journal of Diabetes · doi:10.15277/bjd.2018.192 · Cited by 5 · see citing works
Testosterone, HIV, and cardiovascular disease risk
Grant, J. K., Loyd, Q., & Martinez, C. A. (2020) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000236 · Cited by 4 · see citing works
Reid, K. F., Storer, T. W., & Bhasin, S. (2023) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18293 · Cited by 4 · see citing works
Self-citationLieberman, H. R., Caldwell, J. A., Vartanian, O. A., Carmichael, O. T., Karl, J. P., Berryman, C. E., Gadde, K. M., Niro, P. J., Harris, M. N., Rood, J. C., et al. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06502-8 · Cited by 5 · see citing works
Diagnosis and management of cystinosis: systematic review for a clinical practice guideline
Ledinger, D., Nußbaumer-Streit, B., Piso, B., Dobrescu, A. I., Gadinger, A., Klerings, I., Hohenfellner, K., & Sommer, I. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-03974-z · Cited by 3 · see citing works
Endocrine disorders linked to chronic kidney disease: Mechanisms and clinical implications
Concepción‐Zavaleta, M. J., Fuentes‐Mendoza, J. M., López-Ramírez, E. P., Martínez-García, J. A., Urteaga, L. A. C., & Paz‐Ibarra, J. (2026) · World Journal of Nephrology · doi:10.5527/wjn.v15.i1.113875 · Cited by 3 · see citing works
- Authors
- Ponce, O. J., Spencer-Bonilla, G., Alvarez-Villalobos, N., Serrano, V., Singh-Ospina, N., Rodriguez-Gutierrez, R., Salcido-Montenegro, A., Benkhadra, R., Prokop, L. J., Bhasin, S., & Brito, J. P.
- Affiliations
- Mayo Clinic (US)
- Knowledge and Evaluation Research Unit, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota
- Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, Florida
- Universidad Autonoma de Nuevo Leon, Hospital Universitario “Dr. José E. Gonzalez,” Plataforma INVEST-KER Mexico, Monterrey, Nuevo León, México
- Brigham and Women's Hospital (US)
- Corresponding author
- Brito, Juan P
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2018-03-17
- Volume
- 103
- Issue
- 5
- Pages
- 1745-1754
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2792321631
- Cited by
- 148
- References
- 39
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 24 · 2021: 22 · 2020: 14 · 2019: 20 · 2018: 13
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- testosterone replacement therapy, male hypogonadism, sexual desire, erectile function, sexual satisfaction, erythrocytosis, lower urinary tract symptoms, adverse events
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