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Erectile Dysfunction: An Umbrella Review of Meta-Analyses of Risk-Factors, Treatment, and Prevalence Outcomes

Allen, Mark S., Walter, Emma E.·2019·The Journal of Sexual Medicine

DOI 10.1016/j.jsxm.2019.01.314

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Abstract

INTRODUCTION: Erectile dysfunction (ED) is a major health care problem that has implications for quality of life. AIM: This umbrella review sought to synthesize all meta-analytic research on risk factors, treatment, and prevalence of ED. METHODS: 8 electronic databases were searched for relevant meta-analyses in June 2018. The evidence was graded with 2 measures that use quantitative criteria to establish the quality of report writing and confidence in the effect size reported. MAIN OUTCOME MEASURES: Lifestyle factors, genetic markers, medical conditions, treatments. RESULTS: In total, 98 meta-analyses were identified that included 421 meta-analytic effects, 4,188 primary-effects, and 3,971,122 participants. Pooled estimates showed that an unhealthy lifestyle, genetic markers, and medical conditions were associated with an increased risk of ED. Testosterone therapy and phosphodiesterase type 5 inhibitors showed the greatest treatment efficacy, with mild adverse events observed across treatments. Psychological and behavior change interventions produced effect sizes that were comparable to medication but had greater imprecision in effect sizes. There was little evidence that combined treatments were more efficacious than single treatments. Meta-analyses of prevalence estimates showed consistent age trends but were limited to particular regions or clinical samples, meaning that global estimates of ED are difficult to determine. CLINICAL IMPLICATIONS: The umbrella review synthesized findings for many treatment options that might aid evidence-based clinical decision-making. Based on prevalence estimates, we recommend that primary care physicians take a proactive approach and enquire about erectile problems in all men over age 40 displaying any health-related issue (eg, overweight, cigarette smoking). STRENGTHS & LIMITATIONS: Strengths include the calculation and comparison of summary estimates across multiple meta-analyses. Limitations include heterogeneity in research quality across research themes limiting effect size comparisons. CONCLUSION: The review provides summary estimates for 37 risk factors and 28 treatments. Meta-analyses of risk factors often did not control for important confounders, and meta-analyses of randomized trials were not exclusive to double-blinded trials, active placebo controls, or tests of long-term effects. We recommend further meta-analyses that eliminate lower quality studies and further primary research on behavioral and combined treatments. Allen MS, Walter EE. Erectile Dysfunction: An Umbrella Review of Meta-Analyses of Risk-Factors, Treatment, and Prevalence Outcomes. J Sex Med 2019;16:531-541.

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Spallone, V., Agrò, E. F., Centello, R., Lecis, C., Orecchia, L., & Isidori, A. M. (2023) · Contemporary diabetes · doi:10.1007/978-3-031-15613-7_28 · Cited by 3
Low-intensity shockwave therapy for erectile dysfunction
Ergun, O., Kim, K., Kim, M. H., Hwang, E. C., Blair, Y. A., Güdeloğlu, A., Parekattil, S. J., & Dahm, P. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013166.pub2 · Cited by 2
Prevalence of erectile dysfunction and its moderate to severe associated factors among primary care clinics attendees
Arsat, M. H. M., Abdullah, N. N., & Aimran, N. (2025) · Discover Public Health · doi:10.1186/s12982-025-00458-0 · Cited by 2
Brazilian version of the Brief Male Sexual Function Inventory (BSFI) in adult men: cultural adaptation and measurement properties
da Silva, E. V., de Arruda, G. T., Berni, E. B., Candido, A. D. S., Pivetta, H. M. F., & Braz, M. M. (2025) · Sexual Medicine · doi:10.1093/sexmed/qfaf029 · Cited by 2
Can smoking cause impotence? a radiological retrospective cohort study comparing internal pudendal artery calcification on CT in male smokers versus non-smokers
Tong, E., McDonnell, C., Hunter, K., Sheahan, K. P., & Torreggiani, W. C. (2022) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-022-02948-5 · Cited by 2
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Henríquez‐Beltrán, M., Cigarroa, I., Enos, D., Lastra, J., Nova‐Lamperti, E., & Gonzalo Labarca, T. (2022) · Revista médica de Chile · doi:10.4067/s0034-98872022000600744 · Cited by 2
Computational exploration of aphrodisiac potential: identifying inhibitors from Tribulus terrestris L., and Securidaca longepedunculata targeting human phosphodiesterase 5
Ahmed, S. A., Aremu, A. A., Shafiq, M., & Ul‐Haq, Z. (2025) · In Silico Pharmacology · doi:10.1007/s40203-025-00402-9 · Cited by 1
Pharmacokinetics of an oral versus intranasal delivered formulation of the phosphodiesterase type 5 inhibitor vardenafil in healthy men – a phase 1, randomized, open-label, single-dose, two-period, two-treatment, cross-over study
Chung, E., Argent, C., & Strange, G. A. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107226 · Cited by 1
Lifestyle Interventions to Pre-empt Erectile Dysfunction and Associated Comorbidities
Sansone, A., & Şerefoğlu, E. C. (2025) · Trends in andrology and sexual medicine · doi:10.1007/978-3-031-98580-5_5 · Cited by 1
Glycaemic Control and Erectile Function: Unravelling the Links to Type 2 Diabetes Mellitus
Corona, G., & Reisman, Y. (2025) · Trends in andrology and sexual medicine · doi:10.1007/978-3-031-98580-5_3 · Cited by 1
Current treatment for erectile dysfunction: an umbrella review of systematic reviews and meta-analyses
Ma, J., Wei, J., Li, J., Yu, M., Lu, S., Zeng, H., Xu, L., Dong, Y., Ma, Z., & Zhang, P. (2026) · The Aging Male · doi:10.1080/13685538.2026.2640765 · Cited by 1
Changes in frequency of urology clinic visits and diagnosis of erectile dysfunction in Germany before and during COVID-19
Štefanac, S., Smith, L., Grabovac, I., Jacob, L., Sánchez, G. F. L., Ilie, P. C., Koyanagi, A., Schiffler, T., & Kostev, K. (2023) · Revue d Épidémiologie et de Santé Publique · doi:10.1016/j.respe.2023.102181 · Cited by 1
Editorial Comment: Effect of smoking cessation on sexual function in men aged 30 to 60 years
Ros, C. T. D., & Fácio, F. N. (2020) · International braz j urol · doi:10.1590/s1677-5538.ibju.2019.0541.1
Excision and patch grafting
Ziegelmann, M., & Levine, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819468-3.00013-6
Estudo da expressão dos MicroRNAs miR-15 b, miR-16, miR-138, miR-221 e miR-222 em corpos cavernosos e sangue de ratos submetidos ao alcoolismo e diabetes mellitus
Tiraboschi, R. B. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2020.tde-04012021-115429
Development of the Complex Intervention: Physical Activity to reduce Vascular Erectile Dysfunction
Gerbild, H. N. (2021) · doi:10.54337/aau423681215
Management of erectile dysfunction in primary care
Varma, R., & Sellaturay, S. (2021) · InnovAiT Education and inspiration for general practice · doi:10.1177/17557380211037365
I disordini endocrini nella pratica clinica: epidemiologia e domanda di salute nella vita reale
Crafa, A., Calogero, A. E., Condorelli, R. A., Cannarella, R., & Vignera, S. L. (2021) · L Endocrinologo · doi:10.1007/s40619-021-00961-x
Erectile Dysfunction: Identification, Assessment, Treatment, and Follow-Up
Jensen, P. K., & Albaugh, J. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-45267-4_4
References
Liddon, L., & Barry, J. A. (2021) · Wiley eBooks · doi:10.1002/9781119685340.biblio
Sexuelle Funktionsstörungen
Marhenke, T. (2020) · Essentials · doi:10.1007/978-3-658-32169-7_2
The Efficacy of Tribulus terrestris and Cumminum cyminium Against Sexual Dysfunction in Diabetic Male Rats
Kumar, A., Neupane, N. P., Khalilullah, H., Dahiya, V., Agrawal, S., & Verma, A. (2022) · Current Traditional Medicine · doi:10.2174/2215083808666220608102918
Sexual Dysfunction
Marhenke, T. (2022) · Essentials · doi:10.1007/978-3-658-35721-4_2
Precarious Manhood Beliefs are Positively Associated With Erectile Dysfunction in Cisgender MenPreprint
Walther, A., & Eggenberger, L. (2022) · doi:10.31234/osf.io/rm4qx
Peyronie’s Disease
Palumbo, F., Sebastiani, F., Procacci, A., d’Altilia, N., Ricapito, A., & Cormio, L. (2022) · Springer eBooks · doi:10.1007/978-3-031-11701-5_6
Treatment of Men with Erectile Dysfunction through Lifestyle Modification Using a Digital Application - A Pilot Study
Beecken, W.-D., Hoeh, B., Chun, F. K. ‐., Blume, G., & Kersting, M. (2022) · Journal of Sexual Medicine & Research · doi:10.47363/jsmr/2022(1)106
A commentary on: “Erectile dysfunction in patients with anxiety disorders: a systematic review”
Ergun, O., & Güdeloğlu, A. (2023) · International Journal of Impotence Research · doi:10.1038/s41443-023-00756-8
Investigating the Rate of Sexual Disorders in Men With a Recent COVID-19 Infection Referred to the Tadbir Clinic in Urmia
(2023) · Journal of Medical Clinical Case Reports · doi:10.47485/2767-5416.1040
References
Barry, J. A., & Liddon, L. (2021) · Wiley eBooks · doi:10.1002/9781119685340.refs
The penile prosthesis implantation: the current experience of surgical treatment for erectile dysfunction.
Menshchikov, K. (2024) · Archives of Urology and Nephrology · doi:10.58489/2836-5828/008
Aqueous extract of Pycnanthus angolensis (Welw.) Warb. (Myristicaceae) alleviates paroxetine-induced erectile dysfunction in male rats
Béboy, S. N. E., Mbog, L. M. C.-C., Jignoua, Y. S., Keumedjio, P. T., Feune, P. K. M., & Moundipa, P. F. (2024) · The Journal of Phytopharmacology · doi:10.31254/phyto.2024.13311
Comorbidities, Modifiable Risk Factors, and Erectile Dysfunction
El‐Achkar, A., Hawksworth, D. J., & Burnett, A. L. “. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21477-6.00096-1
Mendelian Randomization Reveals Serum Copper as a Micronutrient is a Risk Factor for Erectile Dysfunction
Wu, W.-S., Qianqian, Y., Aisha, A., Fan, C., & Fangmin, C. (2024) · Biological Trace Element Research · doi:10.1007/s12011-024-04377-0

Authors: Allen, M. S., & Walter, E. E.
Affiliations: University of Wollongong (AU)
Corresponding author: Allen, Mark S.
ORCID: Allen, Mark S.
Walter, Emma E.
Venue: The Journal of Sexual Medicine
Publisher: Oxford University Press (OUP)
Published: 2019-03-01
Volume: 16
Issue: 4
Pages: 531-541
ISSN: 1743-6095 (ISSN-L)
1743-6109
DOI: 10.1016/j.jsxm.2019.01.314
OpenAlex: W2920406111
Cited by: 116
References: 80
Citations by year: 2026: 12 · 2025: 22 · 2024: 14 · 2023: 16 · 2022: 15 · 2021: 16 · 2020: 16 · 2019: 5
FWCI: 2.20
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Sexual Medicine (publishedVersion)
PubMed (publishedVersion)
Research Online (University of Wollongong) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: erectile dysfunction, risk factors, erectile dysfunction treatment, testosterone replacement therapy, phosphodiesterase-5 inhibitors, lifestyle factors, genetic markers, health conditions, psychological intervention, behavioral interventions, combination therapy, adverse events, quality of evidence, primary care screening
MeSH terms: Combined Modality Therapy, Humans, Erectile Dysfunction, Life Style, Male, Quality of Life, Risk Factors, Prevalence, Treatment Outcome, Phosphodiesterase 5 Inhibitors

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Erectile Dysfunction: An Umbrella Review of Meta-Analyses of Risk-Factors, Treatment, and Prevalence Outcomes

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