CoChat
Sign Up
Cited by 86Urological Disorders and TreatmentsSexual function and dysfunction studiesDupuytren's Contracture and Treatments

Peyronie’s disease: Contemporary evaluation and management

Open access
Ziegelmann, Matthew J, Bajic, Petar, Levine, Laurence A·2020·International Journal of Urology
DOI 10.1111/iju.14230
Open this paper in CoChat — free accountOpen PDF

Abstract

Peyronie’s disease is a common yet poorly understood condition characterized by penile pain, curvature, sexual dysfunction and psychological bother. Peyronie’s disease represents a penile wound healing disorder, and is thought to arise from exuberant scarring in response to penile trauma in genetically predisposed men. In the absence of active treatment, the majority of men experience stable or worsening symptoms, with few reporting spontaneous resolution in penile curvature or other deformity. In contrast, penile pain improves or resolves in the majority of men. Treatment options vary based on symptom severity and stability. Several oral therapies are commonly prescribed, although to date there are no strong data to support any oral agents as monotherapy for Peyronie’s disease. Other options including penile traction therapy and intralesional injections result in modest improvements for many patients, particularly when used early after symptom onset. Penile straightening through approaches, such as penile plication and plaque incision or partial excision and grafting, represent the most rapid and reliable approach to correct penile curvature once the symptoms have stabilized. Side‐effects vary based on the type of surgery carried out, and include penile shortening, sensation changes and erectile dysfunction in the minority of men. In patients with drug refractory erectile dysfunction and Peyronie’s disease, placement of a penile prosthesis will address both issues, and is associated with high levels of patient satisfaction. The current review provides a practical approach to the modern evaluation and management of patients presenting with Peyronie’s disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/iju.14230

Cites

159 of 159 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Peyronie's disease progresses in two main stages: an active inflammatory phase typically lasting 12 to 18 months, followed by a chronic stabilized phase.

    “PD progresses in two main stages. The first phase typically lasts between 12 and 18 months; this phase is the “active inflammatory phase”, in which plaque forms and progresses to fibrosis and potential calcification, accompanied by pain and worsening of the penile deformity. In the second phase, known as the chronic “stabilized phase”, penile pain decreases and the plaque size and deformity stabil”

    From Clinical Presentation of Peyronie’s Disease: A Retrospective Study of 564 Cases (2024) · cites this paper as [2]

    The Introduction (page not provided) distinguishes an acute inflammatory phase from a chronic stable phase and describes progressive deformity followed by symptom stability and pain improvement. It does not say the active phase typically lasts 12–18 months; instead, it says there are no firmly agreed criteria for the transition and that many experts consider PD stable after at least 12 months with 3–6 months of stability. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Peyronie's disease only affects genetically predisposed males.

    “PD only affects genetically predisposed males [1,2].”

    From Clinical Presentation of Peyronie’s Disease: A Retrospective Study of 564 Cases (2024) · cites this paper as [2]

    The Abstract says Peyronie’s disease is thought to arise from scarring after penile trauma in genetically predisposed men, and the Introduction describes evidence suggesting a genetic predisposition. Neither passage establishes that it affects only genetically predisposed males; the claim turns a proposed predisposition into an absolute requirement. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 4

  1. [1]1. de la Peyronie F. Sur quelques obstacles qui s' opposent a l'ejaculation nat- urelle de la semence. Mem. Acad. R. Chir. 1743; 1: 425-34.
  2. [48]48. Martin DJ, Badwan K, Parker M, Mulhall JP. Transdermal application of verapamil gel to the penile shaft fails to infiltrate the tunica albuginea. J. Urol. 2002; 168: 2483-5.
  3. [73]73. Wegner HE, Andresen R, Knipsel HH, Miller K. Treatment of Peyronie's disease with local interferon-alpha 2b. Eur. Urol. 1995; 28: 236-40.
  4. [141]141. Carson CC, Levine LA. Outcomes of surgical treatment of Peyronie's dis- ease. BJU Int. 2014; 113: 704-13. 142

Cited by

Sorted by citations

Related

Authors
Ziegelmann, M. J., Bajic, P., & Levine, L. A.
Affiliations
Rush University Medical Center (US)
Corresponding author
Levine, Laurence A
ORCID
Venue
International Journal of Urology
Publisher
Wiley
Published
2020-04-06
Volume
27
Issue
6
Pages
504-516
ISSN
  • 0919-8172 (ISSN-L)
  • 1442-2042
DOI
10.1111/iju.14230
OpenAlex
W3014985269
Cited by
86
References
159
Citations by year
2026: 11 · 2025: 13 · 2024: 26 · 2023: 18 · 2022: 11 · 2021: 5 · 2020: 2
FWCI
2.23
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Urology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
Keywords
Peyronie's disease, penile curvature, penile pain, penile trauma, scar formation, oral therapy, penile traction therapy, intralesional injection, penile plication, penile prosthesis, erectile dysfunction, penile shortening, penile deformity
MeSH terms
Humans, Erectile Dysfunction, Male, Penile Diseases, Penile Induration, Penis, Injections, Intralesional

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review