Daily Oral l-Arginine Plus Tadalafil in Diabetic Patients with Erectile Dysfunction: A Double-Blinded, Randomized, Controlled Clinical Trial
Abstract
Introduction: Erectile dysfunction is a common condition among diabetic men. Many treatments are now available with variable responses. Aim: This study aimed to evaluate the effect of daily oral l-arginine plus tadalafil in diabetic patients with mild to moderate erectile dysfunction. Methods: A double-blinded, randomized, controlled clinical trial was conducted with 108 diabetic male patients. Each patient was assessed by medical and sexual histories, International Index of Erectile Function 5-item questionnaires, pharmaco-penile duplex ultrasonography, and serum testosterone level. Main Outcome Measure: Improvement in International Index of Erectile Function 5-item, serum testosterone level and pharmaco-penile duplex ultrasonography. Results: Erectile functions were significantly improved in all patients after treatment as compared with baseline and placebo (P < .001). Patients who received both drugs showed significant improvement compared to those treated with single drugs, as assessed by International Index of Erectile Function scores and total testosterone (P < .001). Pharmaco-penile ultrasound duplex results showed non-significant differences among patients treated with both drugs and those with each drug alone. Conclusion: Daily use of l-arginine with tadalafil significantly increased the International Index of Erectile Function scores and total testosterone levels as compared to each drug alone in diabetic patients with erectile dysfunction. No differences were found based on pharmaco-penile duplex findings.
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Previous studies on the effectiveness of L-arginine in treating sexual disorders in men reported promising results.
“Previous studies on the effectiveness of L-arginine in treating sexual disorders in men were conducted, and promising results reported [31–33].”
From Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial (2024) · cites this paper as [31]
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- Authors
- El Taieb, M., Hegazy, E., & Ibrahim, A.
- Affiliations
- Department of Dermatology, Venereology and Andrology , Sahary City, Aswan , Egypt
- South Valley University (EG)
- Assiut University (EG)
- Venue
- The Journal of Sexual Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-07-17
- Volume
- 16
- Issue
- 9
- Pages
- 1390-1397
- ISSN
- 1743-6095 (ISSN-L)
- 1743-6109
- OpenAlex
- W2957026893
- Cited by
- 22
- References
- 37
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2022: 6 · 2021: 9 · 2020: 2
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The Journal of Sexual Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- erectile dysfunction, diabetes mellitus, L-arginine, tadalafil, combination therapy, International Index of Erectile Function, serum testosterone, penile blood flow
- MeSH terms
- Tadalafil, Adult, Arginine, Double-Blind Method, Humans, Erectile Dysfunction, Male, Middle Aged, Penile Erection, Treatment Outcome, Diabetes Complications, Phosphodiesterase 5 Inhibitors
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