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Cited by 14Thermal Regulation in MedicineTraumatic Brain Injury and Neurovascular DisturbancesUltrasound and Hyperthermia Applications

The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.

An integrated model of thermodynamic–hemodynamic–pharmacokinetic system and its application on decoupling control of intracranial temperature and pressure in brain hypothermia treatment

Gaohua, Lu, Maekawa, Tsuyoshi, Kimura, Hidenori·2006·Journal of Theoretical Biology
DOI 10.1016/j.jtbi.2006.01.033
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Abstract

Brain hypothermia treatment (BHT) is an intensive care characterized by simultaneous managements of various vital signs, such as intracranial temperature (ICT) and pressure (ICP), of the severe neuropatient. Medical treatments including therapeutic ambient cooling and diuresis are separately carried out based on the experience of the medical staff involved in the clinical management of various pathophysiological processes, such as thermodynamics, hemodynamics and pharmacokinetics. However, no special attention has been paid to the interactions among these subsystems in therapeutic hypothermia because of the lack of theoretical knowledge. Therefore, quantitative analyses using an integrated model of various physiological processes and their interactions are of pressing need. In the present paper, we propose a general compartmental model to describe the pathophysiological processes of the three aforementioned dynamics, on account of the dynamical analogy of temperature, pressure and concentration. The model is verified by the agreement of model-based simulation results with clinical evidence. Based on responses of the integrated model to various stimuli, a transfer function matrix is identified to linearly approximate the characteristic interrelationships between medical treatments (ambient cooling and diuresis) and the vital signs (ICT and ICP). Then a controller that decouples ambient cooling and diuresis is proposed for efficient management of ICT and ICP, enhancement of hypothermic decompression and reduction of diuretic dosage. Decoupling control simulation indicates that ICT and ICP of the integrated model, representing a patient under BHT, can be simultaneously regulated by a single PID controller for ambient cooling and another for diuresis. The proposed decoupler effectively establishes hypothermic decompression, reduces the dosage of diuretic and improves ICP management. Theoretical analyses of the integrated model and decoupling control of ICT and ICP provide insights into the intensive care of various pathophysiological processes in patients undergoing BHT.

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Crossref · 10.1016/j.jtbi.2006.01.033

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57 of 57 references verified0 citation errors · 0 not checkable

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  • In an integrative model developed by the authors previously for systems medicine in the intensive care unit, the body is approximated by 6 segments or 13 compartments, and various parameters are determined mainly from the literature.

    “In an integrative model developed by the authors previously for systems medicine in the intensive care unit, the body is approximated by 6 segments (cranial, cardiocirculatory, lungs, muscle, visceral and others) or 13 compartments, and various parameters are determined mainly from the literature [18-21].”

    From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [21]

  • Various physiological parameters, such as distribution volume, blood flow and metabolic allocation, are common to the current model and the integrated model developed previously for systems medicine in the intensive care.

    “Various physiological parameters, such as distribution volume, blood flow and metabolic allocation, are common to the current model and the integrated model developed previously for systems medicine in the intensive care [18-21].”

    From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [21]

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Metadata

Authors
Gaohua, L., Maekawa, T., & Kimura, H.
Affiliations
  • RIKEN (JP)
  • Yamaguchi University (JP)
Corresponding author
Gaohua, Lu
ORCID
Venue
Journal of Theoretical Biology
Publisher
Elsevier BV
Published
2006-09
Volume
242
Issue
1
Pages
16-31
ISSN
0022-5193 (ISSN-L)
DOI
10.1016/j.jtbi.2006.01.033
OpenAlex
W2051834051
Cited by
14
References
58
Citations by year
2023: 1 · 2019: 2 · 2017: 1 · 2014: 1
FWCI
2.68
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Theoretical Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
RIKEN
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
Keywords
intracranial pressure, compartmental model, diuresis, decoupling control, PID controller, intensive care, transfer function matrix
MeSH terms
Brain, Brain Injuries, Computer Simulation, Diuretics, Osmotic, Humans, Hypothermia, Induced, Intracranial Pressure, Mannitol, Models, Neurological, Temperature, Thermodynamics

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