The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.
Simulation of propofol anaesthesia for intracranial decompression using brain hypothermia treatment
Open accessAbstract
BACKGROUND: Although propofol is commonly used for general anaesthesia of normothermic patients in clinical practice, little information is available in the literature regarding the use of propofol anaesthesia for intracranial decompression using brain hypothermia treatment. A novel propofol anaesthesia scheme is proposed that should promote such clinical application and improve understanding of the principles of using propofol anaesthesia for hypothermic intracranial decompression. METHODS: Theoretical analysis was carried out using a previously-developed integrative model of the thermoregulatory, hemodynamic and pharmacokinetic subsystems. Propofol kinetics is described using a framework similar to that of this model and combined with the thermoregulation subsystem through the pharmacodynamic relationship between the blood propofol concentration and the thermoregulatory threshold. A propofol anaesthesia scheme for hypothermic intracranial decompression was simulated using the integrative model. RESULTS: Compared to the empirical anaesthesia scheme, the proposed anaesthesia scheme can reduce the required propofol dosage by more than 18%. CONCLUSION: The integrative model of the thermoregulatory, hemodynamic and pharmacokinetic subsystems is effective in analyzing the use of propofol anaesthesia for hypothermic intracranial decompression. This propofol infusion scheme appears to be more appropriate for clinical application than the empirical one.
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Various physiological parameters, such as distribution volume, blood flow and metabolic allocation, are common to the current model and the integrated model developed previously for systems medicine in the intensive care.
“Various physiological parameters, such as distribution volume, blood flow and metabolic allocation, are common to the current model and the integrated model developed previously for systems medicine in the intensive care [18-21].”
From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [19]
The Model description (page unavailable) says the thermoregulatory and hemodynamic parts of the earlier integrative model were reused unchanged, and it identifies distribution volume and blood flow in the current model. The Discussion (page unavailable) mentions metabolism, but our copy does not identify “metabolic allocation” as a parameter common to both models. (LLM, conf=0.82)
Experimental — accuracy not yet measuredIn an integrative model developed by the authors previously for systems medicine in the intensive care unit, the body is approximated by 6 segments or 13 compartments, and various parameters are determined mainly from the literature.
“In an integrative model developed by the authors previously for systems medicine in the intensive care unit, the body is approximated by 6 segments (cranial, cardiocirculatory, lungs, muscle, visceral and others) or 13 compartments, and various parameters are determined mainly from the literature [18-21].”
From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [19]
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Cites
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Mild Hypothermia Alters Propofol Pharmacokinetics and Increases the Duration of Action of Atracurium
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Application of therapeutic hypothermia in the intensive care unit
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Propofol Linearly Reduces the Vasoconstriction and Shivering Thresholds
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Human physiologically based pharmacokinetic model for propofol
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Hypertonic saline for cerebral edema
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A mathematical model of intracranial pressure dynamics for brain hypothermia treatment
Gaohua, L., & Kimura, H. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2005.06.036 · Cited by 19
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Self-citationTherapeutische Hypothermie nach Sch�del-Hirn-Trauma oder Subarachnoidalblutung
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A mathematical model of brain glucose homeostasis
Gaohua, L., & Kimura, H. (2009) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-6-26 · Cited by 29
Self-citationPhysiologically Based Structure of Mean Residence Time
Ďurišová, M. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/610631 · Cited by 7
Compound control — adaptation to multiple environmental changes
Tanaka, R. J., Gaohua, L., Shimoda, S., & Kimura, H. (2009) · IEEE Conference on Decision and Control (CDC) · doi:10.1109/cdc.2009.5399787 · Cited by 2
Self-citationA Control-Theoretical Approach to Model-Based Medicine
Gaohua, L., & Kimura, H. (2008) · IFAC Proceedings Volumes · doi:10.3182/20080706-5-kr-1001.01832 · Cited by 1
Self-citationGaohua, L., & Kimura, H. (2009) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-540-92841-6_410
Self-citationDjilvesi, D., Tubić, T., Prijić, S. M., & Golubović, J. (2025) · Clinical and Translational Neuroscience · doi:10.3390/ctn9040053
Metadata
- Authors
- Gaohua, L., & Kimura, H.
- Affiliations
- RIKEN (JP)
- Corresponding author
- Gaohua, Lu
- Venue
- Theoretical Biology and Medical Modelling
- Published
- 2007-11-29
- Volume
- 4
- Issue
- 1
- Pages
- 46-46
- ISSN
- 1742-4682 (ISSN-L)
- PMC
- PMC2217543
- OpenAlex
- W2133568313
- Cited by
- 6
- References
- 19
- Citations by year
- 2025: 1 · 2012: 1
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Theoretical Biology and Medical Modelling (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Health Sciences › Medicine › Physiology (medical) › Biomedical and Chemical Research
- Keywords
- propofol anesthesia, intracranial decompression, cerebral hypothermia, integrative model, thermoregulation, hemodynamics, pharmacokinetics, pharmacodynamics
- MeSH terms
- Anesthesia, Arteries, Blood-Brain Barrier, Body Temperature Regulation, Brain, Computer Simulation, Dose-Response Relationship, Drug, Humans, Hypothermia, Induced, Models, Theoretical, Osmolar Concentration, Permeability, Propofol, Anesthetics, Intravenous, Decompression, Surgical
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