Cited by 155Protist diversity and phylogenyOrigins and Evolution of LifeEvolution and Genetic Dynamics

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Symbiosis in eukaryotic evolution

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López-García, Purificación, Eme, Laura, Moreira, David·2017·Journal of Theoretical Biology

DOI 10.1016/j.jtbi.2017.02.031PMC PMC5638015

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Abstract

Fifty years ago, Lynn Margulis, inspiring in early twentieth-century ideas that put forward a symbiotic origin for some eukaryotic organelles, proposed a unified theory for the origin of the eukaryotic cell based on symbiosis as evolutionary mechanism. Margulis was profoundly aware of the importance of symbiosis in the natural microbial world and anticipated the evolutionary significance that integrated cooperative interactions might have as mechanism to increase cellular complexity. Today, we have started fully appreciating the vast extent of microbial diversity and the importance of syntrophic metabolic cooperation in natural ecosystems, especially in sediments and microbial mats. Also, not only the symbiogenetic origin of mitochondria and chloroplasts has been clearly demonstrated, but improvement in phylogenomic methods combined with recent discoveries of archaeal lineages more closely related to eukaryotes further support the symbiogenetic origin of the eukaryotic cell. Margulis left us in legacy the idea of 'eukaryogenesis by symbiogenesis'. Although this has been largely verified, when, where, and specifically how eukaryotic cells evolved are yet unclear. Here, we shortly review current knowledge about symbiotic interactions in the microbial world and their evolutionary impact, the status of eukaryogenetic models and the current challenges and perspectives ahead to reconstruct the evolutionary path to eukaryotes.

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Authors: López-García, P., Eme, L., & Moreira, D.
Affiliations: Dalhousie University (CA)
Université Paris-Sud (FR)
ORCID: Eme, Laura
Moreira, David
Venue: Journal of Theoretical Biology
Publisher: Elsevier BV
Published: 2017-12
Volume: 434
Pages: 20-33
ISSN: 0022-5193 (ISSN-L)
DOI: 10.1016/j.jtbi.2017.02.031
PMC: PMC5638015
OpenAlex: W2592590328
Cited by: 154
References: 206
Citations by year: 2026: 8 · 2025: 14 · 2024: 12 · 2023: 14 · 2022: 15 · 2021: 18 · 2020: 24 · 2019: 24 · 2018: 13 · 2017: 12
FWCI: 8.16
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Theoretical Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: European Research Council Advanced (322669)
Topics: Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: symbiosis, eukaryotic origin, symbiogenesis, Lynn Margulis, endosymbiotic origin of mitochondria, chloroplast origin, eukaryotic organelles, microbial mats, sediment microbial communities, archaea, phylogenomics, eukaryotic evolution
MeSH terms: Eukaryotic Cells, Biological Evolution, Symbiosis, Ecosystem, Eukaryota, Microbiota

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