The DOI matches its Crossref record; 206 of the 206 references it cites were found in a registry or an index.
Symbiosis in eukaryotic evolution
Open accessAbstract
Fifty years ago, Lynn Margulis, inspiring in early twentieth-century ideas that put forward a symbiotic origin for some eukaryotic organelles, proposed a unified theory for the origin of the eukaryotic cell based on symbiosis as evolutionary mechanism. Margulis was profoundly aware of the importance of symbiosis in the natural microbial world and anticipated the evolutionary significance that integrated cooperative interactions might have as mechanism to increase cellular complexity. Today, we have started fully appreciating the vast extent of microbial diversity and the importance of syntrophic metabolic cooperation in natural ecosystems, especially in sediments and microbial mats. Also, not only the symbiogenetic origin of mitochondria and chloroplasts has been clearly demonstrated, but improvement in phylogenomic methods combined with recent discoveries of archaeal lineages more closely related to eukaryotes further support the symbiogenetic origin of the eukaryotic cell. Margulis left us in legacy the idea of 'eukaryogenesis by symbiogenesis'. Although this has been largely verified, when, where, and specifically how eukaryotic cells evolved are yet unclear. Here, we shortly review current knowledge about symbiotic interactions in the microbial world and their evolutionary impact, the status of eukaryogenetic models and the current challenges and perspectives ahead to reconstruct the evolutionary path to eukaryotes.
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Items 201–206 of 206
Lake, J. A. (1987) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1987.052.01.091 · Cited by 23
Microbial Diversity: A Bonanza of Phyla
Eme, L., & Doolittle, W. F. (2015) · Current Biology · doi:10.1016/j.cub.2014.12.044 · Cited by 21
Self-citationCerqueda‐García, D., Martínez-Castilla, L. P., Falcón, L. I., & Delaye, L. (2013) · The ISME Journal · doi:10.1038/ismej.2013.207 · Cited by 17
Community living long before manFossil and living microbial mats and early life
Margulis, L., Baluja, L. L., Awramik, S. M., & Sagan, D. (1986) · The Science of The Total Environment · doi:10.1016/0048-9697(86)90342-6 · Cited by 10
Erratum: Unusual marine unicellular symbiosis with the nitrogen-fixing cyanobacterium UCYN-A
Zehr, J. P., Shilova, I. N., Farnelid, H., Muñoz‐Marín, M. D. C., & Turk‐Kubo, K. A. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.16 · Cited by 8
Collins, A. G. (2000) · doi:10.1666/0094-8373(2000)026
Flagged first, then by citations
Research works printed but not linked: 3
- Cavalier-Smith, 1989, Molecular phylogeny, Archaebacteria Archezoa. Nat., 339, l00
- Mereschkowsky, 1905, Über natur und usprung der chromatophoren im pflanzenreiche, Biol. Cent., 25, 593
- Yan, 1993, Significance of eukaryotic organisms in the microfossil flora of Changcheng system, Acta Micropalaeontol Sin., 10, 167
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CHALLIS, R. J., Richards, E., Rajan, J., Cochrane, G., & Blaxter, M. (2020) · G3 Genes Genomes Genetics · doi:10.1534/g3.119.400908 · Cited by 2,600
The Origin and Diversification of Mitochondria
Roger, A. J., Muñoz-Gómez, S. A., & Kamikawa, R. (2017) · Current Biology · doi:10.1016/j.cub.2017.09.015 · Cited by 1,142
Soil protists: a fertile frontier in soil biology research
Geisen, S., Mitchell, E. A. D., Adl, S. M., Bonkowski, M., Dunthorn, M., Ekelund, F., Fernández, L. D., Jousset, A., Krashevska, V., Singer, D., et al. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy006 · Cited by 756
Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry
Shehata, A. A., Yalçın, S., Latorre, J. D., Basiouni, S., Attia, Y. A., El‐Wahab, A. A., Visscher, C., El-Seedi, H. R., Huber, C., Hafez, H. M., et al. (2022) · Microorganisms · doi:10.3390/microorganisms10020395 · Cited by 329
Origin of viruses: primordial replicators recruiting capsids from hosts
Krupovìč, M., Dolja, V. V., & Koonin, E. V. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0205-6 · Cited by 213
Metadata
- Authors
- López-García, P., Eme, L., & Moreira, D.
- Affiliations
- Dalhousie University (CA)
- Université Paris-Sud (FR)
- Venue
- Journal of Theoretical Biology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 434
- Pages
- 20-33
- ISSN
- 0022-5193 (ISSN-L)
- PMC
- PMC5638015
- OpenAlex
- W2592590328
- Cited by
- 154
- References
- 206
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 12 · 2023: 14 · 2022: 15 · 2021: 18 · 2020: 24 · 2019: 24 · 2018: 13 · 2017: 12
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Theoretical Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- European Research Council Advanced (322669)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- symbiosis, eukaryotic origin, symbiogenesis, Lynn Margulis, endosymbiotic origin of mitochondria, chloroplast origin, eukaryotic organelles, microbial mats, sediment microbial communities, archaea, phylogenomics, eukaryotic evolution
- MeSH terms
- Eukaryotic Cells, Biological Evolution, Symbiosis, Ecosystem, Eukaryota, Microbiota
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