Persistent atrial fibrillation in a goat model of chronic left atrial overload
Open accessAbstract
Objectives Atrial dilatation predisposes to atrial fibrillation. Although several animal models focus on the initiating mechanisms of atrial fibrillation in dilated atria, a model of left atrial overload resulting in persistent atrial fibrillation in nonanesthetized animals has not been presented thus far.Methods In 24 goats a vascular shunt was implanted between the aorta and the left atrium through a left thoracotomy. In 6 animals the shunt was ligated immediately (control group). Ultrasonic crystals were implanted to monitor atrial dilatation. Bipolar electrodes were positioned epicardially on the left atrium for measurement of the atrial effective refractory period, conduction times, and atrial fibrillation duration.Results Four weeks of overload resulted in an increase of left atrial pressure (23.1 +/- 6.8 mm Hg in the open-shunt group vs 7.0 +/- 1.9 mm Hg in the control group, P = .002) and a progressive dilatation of the left atrium (135% +/- 20% in the open-shunt group vs 98% +/- 8.0% in the control group, P = .002). Among the open-shunt group's long-term survivors (n = 12), 9 animals showed prolonged atrial fibrillation (>1 hour), and of these, 6 were in persistent atrial fibrillation (>1 week). The atrial effective refractory period increased during the first week and remained prolonged until death (182 +/- 11 ms in the open-shunt group vs 161 +/- 15 ms, P = .03). The conduction time did not change. An increase in collagen formation was noticed in both groups, without a significant difference between them.Conclusions A chronic aortic to left atrial shunt is a feasible model in the goat. It induces progressive left atrial dilatation with an increased atrial fibrillation duration up to hours in the majority of animals. Prolonged atrial fibrillation duration could not be explained by a shortening of atrial effective refractory period or increase in fibrosis.
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The link between female sex and stroke might vary across populations and age groups.
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Atrial Fibrillation Begets Atrial Fibrillation
WIJFFELS, M. C. E. F., Kirchhof, C. J. H. J., Dorland, R., & Allessie, M. A. (1995) · Circulation · doi:10.1161/01.cir.92.7.1954 · Cited by 3,500 · see citing works
Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study
Lloyd-Jones, D. M., Wang, T. J., Leip, E. P., Larson, M. G., Levy, D., Vasan, R. S., D’Agostino, R. B., Massaro, J. M., Beiser, A., Wolf, P. A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000140263.20897.42 · Cited by 2,041 · see citing works
Incidence of and risk factors for atrial fibrillation in older adults
Psaty, B. M., Manolio, T. A., Kuller, L. H., Kronmal, R. A., Cushman, M., Fried, L. P., White, R., Furberg, C. D., & Rautaharju, P. M. (1997) · Circulation · doi:10.1161/01.cir.96.7.2455 · Cited by 1,462 · see citing works
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Frustaci, A., Chimenti, C., Bellocci, F., Morgante, E., Russo, M. A., & Maseri, A. (1997) · Circulation · doi:10.1161/01.cir.96.4.1180 · Cited by 1,400 · see citing works
Promotion of Atrial Fibrillation by Heart Failure in Dogs
Li, D., Fareh, S., Leung, T. K., & Nattel, S. (1999) · Circulation · doi:10.1161/01.cir.100.1.87 · Cited by 1,343 · see citing works
Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study.
Vaziri, S. M., Larson, M. G., Benjamin, E. J., & Levy, D. (1994) · Circulation · doi:10.1161/01.cir.89.2.724 · Cited by 1,073 · see citing works
Morillo, C. A., Klein, G. J., Jones, D. L., & Guiraudon, C. M. (1995) · Circulation · doi:10.1161/01.cir.91.5.1588 · Cited by 1,046 · see citing works
Ravelli, F., & Allessie, M. A. (1997) · Circulation · doi:10.1161/01.cir.96.5.1686 · Cited by 478 · see citing works
Atrial fibrillation complicating the course of degenerative mitral regurgitation
Grigioni, F., Aviérinos, J.-F., Ling, L. H., Scott, C. G., Bailey, K. R., Tajik, A. J., Frye, R. L., & Enriquez-Sarano, M. L. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01922-8 · Cited by 386 · see citing works
Evans, W., & Swann, P. (1954) · Heart · doi:10.1136/hrt.16.2.189 · Cited by 385 · see citing works
Fareh, S., VILLEMAIRE, C., & Nattel, S. (1998) · Circulation · doi:10.1161/01.cir.98.20.2202 · Cited by 350 · see citing works
Verheule, S., Wilson, E., Everett, T. H., Shanbhag, S. M., Golden, C. L., & Olgin, J. E. (2003) · Circulation · doi:10.1161/01.cir.0000066915.15187.51 · Cited by 336 · see citing works
Satoh, T., & Zipes, D. P. (1996) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1996.tb00596.x · Cited by 308 · see citing works
Atrial fibrillation after cardiac operation: risks, mechanisms, and treatment
Hogue, C. W. J., & Hyder, M. (2000) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(99)01267-9 · Cited by 194 · see citing works
Methods in quantitative image analysis
Oberholzer, M., �streicher, M., Christen, H., et al. (1996) · Histochemistry and Cell Biology · doi:10.1007/bf01463655 · Cited by 185 · see citing works
Boyden, P. A., & Hoffman, B. F. (1981) · Circulation Research · doi:10.1161/01.res.49.6.1319 · Cited by 143 · see citing works
Boyden, P. A., Tilley, L. P., Pham, T. D., et al. (1982) · The American Journal of Cardiology · doi:10.1016/0002-9149(82)90208-9 · Cited by 128 · see citing works
Development of a Substrate of Atrial Fibrillation During Chronic Atrioventricular Block in the Goat
Neuberger, H., Schotten, U., Verheule, S., Eijsbouts, S. C. M., Blaauw, Y., van Hunnik, A., & Allessie, M. A. (2005) · Circulation · doi:10.1161/01.cir.0000151517.43137.97 · Cited by 114 · see citing works
Chronic Atrial Dilation, Electrical Remodeling, and Atrial Fibrillation in the Goat
Neuberger, H., Schotten, U., Blaauw, Y., Vollmann, D., Eijsbouts, S. C. M., van Hunnik, A., & Allessie, M. A. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.09.041 · Cited by 98 · see citing works
Some observations on the mechanism of pressure related atrial fibrillation
Sideris, D. A., Toumanidis, S. T., THODORAKIS, M., et al. (1994) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a060433 · Cited by 53 · see citing works
Effect of Nutritional Status on Oxidative Stress in an Ex Vivo Perfused Rat Liver
Stadler, M., Nuyens, V., Seidel, L., et al. (2005) · Anesthesiology · doi:10.1097/00000542-200511000-00012 · Cited by 39 · see citing works
Fraser, H. R. L., & Turner, R. (1955) · BMJ · doi:10.1136/bmj.2.4953.1414 · Cited by 29 · see citing works
Use of intraoperative mapping to optimize surgical ablation of atrial flutter
Yamauchi, S., Schuessler, R. B., Kawamoto, T., Shuman, T. A., Boineau, J. P., & Cox, J. L. (1993) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(93)91172-j · Cited by 16 · see citing works
Yamauchi, S., Boineau, J. P., Schuessler, R. B., & Cox, J. L. (1998) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.62.201 · Cited by 10 · see citing works
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Ko, D., Rahman, F., Schnabel, R. B., Yin, X., Benjamin, E. J., & Christophersen, I. E. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.45 · Cited by 353 · see citing works
Atrial remodeling and atrial fibrillation in acquired forms of cardiovascular disease
Jansen, H. J., Bohne, L. J., Gillis, A. M., & Rose, R. A. (2020) · Heart Rhythm O2 · doi:10.1016/j.hroo.2020.05.002 · Cited by 74 · see citing works
- Authors
- Remes, J., van Brakel, T. J., Bolotin, G., Garber, C., de Jong, M. M., van der Veen, F. H., & Maessen, J. G.
- Affiliations
- Universitair Ziekenhuis Brussel (BE)
- Corresponding author
- Remes, Jan
- ORCID
- Maessen, Jos G.
- Venue
- The Journal of Thoracic and Cardiovascular Surgery
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 136
- Issue
- 4
- Pages
- 1005-1011
- ISSN
- 0022-5223 (ISSN-L)
- OpenAlex
- W2118784425
- Cited by
- 44
- References
- 24
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 9 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thoracic and Cardiovascular Surgery (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- persistent atrial fibrillation, left atrial enlargement, left atrial overload, goat model, atrial effective refractory period, atrial conduction time, atrial fibrosis, collagen synthesis, left atrial pressure
- MeSH terms
- Animals, Aorta, Thoracic, Atrial Fibrillation, Chronic Disease, Dilatation, Pathologic, Disease Models, Animal, Electrocardiography, Goats, Heart Atria, Pressure, Random Allocation, Reference Values, Refractory Period, Electrophysiological, Sensitivity and Specificity, Thoracotomy, Statistics, Nonparametric
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