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Cited by 42Sexual function and dysfunction studiesUrological Disorders and TreatmentsSexuality, Behavior, and Technology

Impact of erectile dysfunction on confidence, self-esteem and relationship satisfaction after 9 months of sildenafil citrate treatment

Althof, Stanley E., O’Leary, Michael P., Cappelleri, Joseph C., Crowley, Arthur R., Tseng, Li-Jung, Collins, Suzanne·2006·Journal of Urology
DOI 10.1016/j.juro.2006.07.019
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Abstract

PURPOSE: The first double-blind, placebo controlled trial in the United States of the Self-Esteem And Relationship questionnaire revealed that treatment with sildenafil citrate improves erectile function and measures of quality of life in men with erectile dysfunction. We investigated long-term improvement, and correlations between improved erectile function and confidence, self-esteem and sexual relationship satisfaction in men with erectile dysfunction. MATERIALS AND METHODS: This was a 36-week open label extension of the double-blind, placebo controlled trial. The blind was not broken. Patients were 18 years or older with clinically diagnosed erectile dysfunction. Erectile function was assessed using the International Index of Erectile Function. Self-esteem, confidence and relationship satisfaction were assessed using the Self-Esteem And Relationship questionnaire. Correlations were determined using Pearson's product moment coefficients. RESULTS: A total of 204 participants were enrolled in the open label extension, including 108 on placebo and 96 on sildenafil. In men who received placebo in the double-blind, placebo controlled phase mean erectile function scores and self-esteem, confidence and relationship satisfaction scores were increased significantly at week 36 of the open label extension (p < 0.0001). Men who received sildenafil in the double-blind, placebo controlled phase maintained high scores in the open label extension. Correlations between improved erectile function, and self-esteem, confidence and relationship satisfaction were strong and positive (p < 0.0001). CONCLUSIONS: Open label extension sildenafil after double-blind, placebo controlled placebo significantly improved erectile function, self-esteem, confidence and relationship satisfaction. Following an initial 12 weeks of double-blind, placebo controlled sildenafil therapy for erectile dysfunction improvements were sustained an additional 9 months. Positive correlations between erectile function, and self-esteem, confidence and relationship satisfaction suggest that improved erectile quality can improve long-term psychosocial quality of life.

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Crossref · 10.1016/j.juro.2006.07.019

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  • Medical treatment is not only indicated for organic ED; PDE5 inhibitors can be used for psychologic ED to reduce failure anxiety and increase self-confidence.

    “Medical treatment is, however, not only indicated in case of organic ED. PDE5 inhibitors, for example, can be used in case of psychologic ED as well to reduce failure anxiety and increase self-confidence as a first step to regain control over their erectile function.113,114”

    From A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM) (2021) · cites this paper as [114]

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Authors
Althof, S. E., O’Leary, M. P., Cappelleri, J. C., Crowley, A. R., Tseng, L.-J., & Collins, S.
Affiliations
  • Harvard University (US)
  • Women’s Hospital, Boston, Massachusetts
  • Pfizer (United States) (US)
  • New York, New York
ORCID
Venue
Journal of Urology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-11
Volume
176
Issue
5
Pages
2132-2137
ISSN
  • 0022-5347 (ISSN-L)
  • 1527-3792
DOI
10.1016/j.juro.2006.07.019
OpenAlex
W2127345086
Cited by
42
References
18
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2015: 1 · 2014: 4 · 2013: 3
FWCI
4.03
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Urology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
  • Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
Keywords
erectile dysfunction, sildenafil citrate, self-esteem, self-confidence, sexual relationship satisfaction, erectile function, psychosocial quality of life, long-term treatment outcomes
MeSH terms
Sildenafil Citrate, Adult, Aged, Aged, 80 and over, Double-Blind Method, Humans, Erectile Dysfunction, Male, Middle Aged, Phosphodiesterase Inhibitors, Piperazines, Purines, Self Concept, Sulfones, Time Factors, Patient Satisfaction

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