Testosterone Supplementation Versus Clomiphene Citrate for Hypogonadism: An Age Matched Comparison of Satisfaction and Efficacy
Abstract
Purpose We compared satisfaction and treatment efficacy in men with symptomatic hypogonadism who received clomiphene citrate or testosterone supplementation therapy. Materials and methods Men treated with clomiphene citrate, or testosterone injections or gels for symptomatic hypogonadism (total testosterone less than 300 ng/dl) reported satisfaction with the current treatment regimen using the qADAM questionnaire. Results A total of 93 men on testosterone injections (31) or gels (31), or clomiphene citrate (31) were age matched from a retrospective cohort of 1,150 on testosterone supplementation therapy. We compared men who received testosterone supplementation therapy to 31 not on such therapy, who served as controls. Median serum testosterone increased from pretreatment levels in all men regardless of therapy with clomiphene citrate, and testosterone injections and gels (from 247 to 504, 224 to 1,104 and 230 to 412 ng/dl, respectively, p 0.05). Men receiving testosterone injections reported greater libido than men on clomiphene citrate (4 vs 3, p = 0.04) or testosterone gels (4 vs 3, p = 0.04), or controls (4 vs 3, p Conclusions Testosterone supplementation regimens and clomiphene citrate are efficacious for improving serum total testosterone. No difference in overall hypogonadal symptoms was noted among men on any testosterone supplementation therapy. Despite lower serum total testosterone, men on clomiphene citrate and testosterone gels reported satisfaction similar to th…
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Multiple studies have shown that clomiphene citrate effectively raises testosterone to eugonadal levels in men with testosterone deficiency.
“CC has long been used as a treatment to restore testosterone levels and promote or preserve spermatogenesis in men with testosterone deficiency desiring to preserve fertility, and multiple studies have shown that CC effectively raises testosterone to eugonadal levels (50-56).”
From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [54]
A cross-sectional retrospective analysis reported similar improvements in ADAM scores between the group treated with clomiphene citrate and the group treated with TRT for symptomatic hypogonadism.
“A cross-sectional retrospective analysis in men treated with clomiphene citrate or TRT for symptomatic hypogonadism, reported similar improvements in ADAM scores between the group treated with clomiphene citrate and TRT [61].”
From Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy (2020) · cites this paper as [61]
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Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy
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Clomiphene Citrate for the Treatment of Hypogonadism
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Self-citationNon-testosterone management of male hypogonadism: an examination of the existing literature
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“testosterone deficiency desiring to preserve fertility, and multiple studies have shown that CC effectively raises testosterone to eugonadal levels (50-56).”
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Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism?
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- Authors
- Ramasamy, R., Scovell, J. M., Kovac, J. R., & Lipshultz, L. I.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Journal of Urology
- Published
- 2014-09
- Volume
- 192
- Issue
- 3
- Pages
- 875-879
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- OpenAlex
- W2059947408
- Cited by
- 84
- References
- 5
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 11 · 2015: 9 · 2014: 7
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Urology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- clomiphene citrate, male hypogonadism, testosterone injection, testosterone gel, treatment satisfaction, serum total testosterone, sexual desire, age-matched comparison
- MeSH terms
- Adult, Age Factors, Androgens, Clomiphene, Cross-Sectional Studies, Gels, Humans, Hypogonadism, Injections, Male, Retrospective Studies, Testosterone, Treatment Outcome, Patient Satisfaction, Selective Estrogen Receptor Modulators
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