Improvement of the Metabolic Syndrome and of Non-alcoholic Liver Steatosis upon Treatment of Hypogonadal Elderly Men with Parenteral Testosterone Undecanoate
Abstract
This is a study of a cohort of 117 men aged between 34-69 years, with plasma testosterone levels between 5.9-12.1 nmol/L (N>14.0 nmol/L) who were treated with administration of testosterone undecanoate for 1 year as the sole intervention. There was a remarkable improvement of body weight, BMI and waist size along with an improvement of lipid profiles. Liver fat is highly significantly and linearly correlated with all components of the metabolic syndrome. Hepatic inflammation secondary to liver steatosis is a potential contributor to the low-grade inflammation associated with the metabolic syndrome. Elevations of liver enzymes are associated with higher CRP concentrations. Levels of ALT (GPT) AST (GOT) and CRP had decreased significantly after one year of testosterone treatment. At baseline 74/117 met the criteria of the metabolic syndrome as defined by the NCEP and after one year of testosterone treatment this number had declined to 42/117.
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Effects of testosterone on lipids appear after 4 weeks and are maximal after 6-12 months.
“Effects on lipids appear after 4 weeks, maximal after 6–12 months.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [32]
Changes in fat mass, lean body mass, and muscle strength can marginally continue over years of testosterone treatment.
“Changes in fat mass, lean body mass, and muscle strength occur within 12–16 weeks, stabilize at 6–12 months, but can marginally continue over years.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [32]
Body mass index declines after 6 months of testosterone treatment, with further improvement during an observation period of 2 years.
“Body mass index as a widely used measure of body composition declined after 6 months with further improvement during an observation period of 2 years (32).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [32]
Testosterone treatment decreases trunk fat or waist circumference after 3 months, with continuous decline over 24 months.
“A decrease in trunk fat or waist circumference was noted in a number of studies after 3 months (35, 36) with continuous decline over 24 months (32)”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [32]
The decrease in serum total cholesterol reaches a maximum after 12 months of testosterone treatment.
“others have found this to occur after 9 months (41) or 12 months (42) with a maximum reached after 12 months (32).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [32]
Testosterone administration decreases C-reactive protein after 3 weeks and after 3 months.
“A decrease in C-reactive protein (CRP) was observed after 3 weeks (63) and in other studies after 3 months (32, 43).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [32]
In the authors' own studies, signs and symptoms of the metabolic syndrome improved substantially following administration of long-acting testosterone undecanoate, and improvements in glycemic control and lipids parallel improvements in body composition.
“In our own studies, signs and symptoms of the metabolic syndrome improved substantially following administration of long-acting testosterone undecanoate (32, 35, 92) and improvements in glycemic control and lipids parallel improvements in body composition.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [32]
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- Authors
- Haider, A., Gooren, L. J. G., Padungtod, P., & Saad, F.
- Affiliations
- Deutsches Schifffahrtsmuseum (DE)
- Venue
- Experimental and Clinical Endocrinology & Diabetes
- Publisher
- Georg Thieme Verlag KG
- Published
- 2009-05-26
- Volume
- 118
- Issue
- 03
- Pages
- 167-171
- ISSN
- 0947-7349 (ISSN-L)
- 1439-3646
- OpenAlex
- W2066024733
- Cited by
- 83
- References
- 35
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2020: 6 · 2019: 3 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 6 · 2012: 7
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental and Clinical Endocrinology & Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- testosterone undecanoate, hypogonadism, metabolic syndrome, non-alcoholic fatty liver disease, hepatic steatosis, older men, lipid profile, body weight, waist circumference, C-reactive protein, liver enzymes, liver inflammation, androgen deficiency
- MeSH terms
- Adult, Aged, Aging, Androgens, C-Reactive Protein, Fatty Liver, Humans, Hypogonadism, Liver, Male, Middle Aged, Testosterone, Cohort Studies, Body Mass Index, Metabolic Syndrome
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