Metabolic syndrome in peripheral arterial disease: relationship with severity of peripheral circulatory insufficiency, inflammatory status, and cardiovascular comorbidity

Brevetti, Gregorio; Schiano, Vittorio; Sirico, Giusy; Giugliano, Giuseppe; Laurenzano, Eugenio; Chiariello, Massimo

doi:10.1016/j.jvs.2006.02.048

Cited by 55Peripheral Artery Disease ManagementDiabetes, Cardiovascular Risks, and LipoproteinsAortic aneurysm repair treatments

Metabolic syndrome in peripheral arterial disease: relationship with severity of peripheral circulatory insufficiency, inflammatory status, and cardiovascular comorbidity

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Brevetti, Gregorio, Schiano, Vittorio, Sirico, Giusy, Giugliano, Giuseppe, Laurenzano, Eugenio, Chiariello, Massimo·2006·Journal of Vascular Surgery

DOI 10.1016/j.jvs.2006.02.048

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Abstract

Objective Metabolic syndrome is defined by the clustering in the same person of at least three risk factors such as hyperglycemia, hypertriglyceridemia, low levels of high-density lipoprotein, hypertension, and abdominal obesity. In patients with peripheral arterial disease (PAD), we investigated the prevalence of metabolic syndrome and its relationship with the severity of peripheral circulatory insufficiency, inflammatory status, and cardiovascular comorbidity.Methods The presence of metabolic syndrome was assessed in 154 consecutive PAD patients (115 men, 39 women). Inflammatory status was assessed by measuring serum levels of C-reactive protein (CRP).Results Metabolic syndrome was present in 51.9% (42.7 % in men, 74.3% in women, P < .01). Patients with an ankle/brachial index (ABI) <0.64 (median) were more likely to have metabolic syndrome than those with less severe PAD (63.9% vs 42.8%, P < .02). The association between a low ABI and metabolic syndrome was maintained after adjustment for age and sex (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.03 to 4.68). Compared with PAD patients without metabolic syndrome, those with the syndrome had greater body mass index (28.2 [25.6; 29.8] kg/m(2) vs 26.1 [24.2; 27.7] kg/m(2), P < .01) and higher levels of CRP (3.9 [1.6; 7.6] mg/L vs 2.0 [1.1; 3.7] mg/L, P < .02). A previous myocardial infarction was documented in 58.2% of patients with and in 37.5% of those without metabolic syndrome (P < .01). At multivariate analysis, metabolic syndrome was significantly associated with previous myocardial infarction also after adjustment for ABI (OR, 2.15; 95% CI, 1.06 to 4.38).Conclusions Metabolic syndrome is present in >50% of PAD patients. The finding that well-established indicators of increased cardiovascular risk such as low ABI and increased CRP levels cluster with metabolic syndrome suggests that identification of this syndrome in these high-risk patients could indicate an even greater risk of cardiovascular events.

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MetS is present in approximately 50% of patients with diagnosed vascular disease and may be even more prevalent among women with ASCVD.
“MetS is present in w50% of patients with diagnosed vascular disease and may be even more prevalent among women with ASCVD (10,11).”
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Authors: Brevetti, G., Schiano, V., Sirico, G., Giugliano, G., Laurenzano, E., & Chiariello, M.
Affiliations: Federico II University Hospital (IT)
Corresponding author: Brevetti, Gregorio
ORCID: Sirico, Giusy
Giugliano, Giuseppe
Venue: Journal of Vascular Surgery
Publisher: Elsevier BV
Published: 2006-07
Volume: 44
Issue: 1
Pages: 101-107
ISSN: 0741-5214 (ISSN-L)
DOI: 10.1016/j.jvs.2006.02.048
OpenAlex: W2012725194
Cited by: 55
References: 39
Citations by year: 2023: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 4
FWCI: 6.10
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2573 d)
Locations: Journal of Vascular Surgery (publishedVersion)
PubMed (publishedVersion)
INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Zenodo (CERN European Organization for Nuclear Research) (other-oa)
Topics: Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic aneurysm repair treatments
Keywords: metabolic syndrome, peripheral arterial disease, peripheral circulatory insufficiency, ankle-brachial index, C-reactive protein, inflammation, cardiovascular comorbidity, myocardial infarction, body mass index, cardiovascular risk, prevalence, sex differences, hypertriglyceridemia, hypertension, abdominal obesity, hyperglycemia, low HDL cholesterol, smoking, alcohol consumption
MeSH terms: Aged, C-Reactive Protein, Cardiovascular Diseases, Female, Humans, Inflammation, Male, Middle Aged, Risk Factors, Venous Insufficiency, Comorbidity, Body Mass Index, Multivariate Analysis, Peripheral Vascular Diseases, Disease Progression, Metabolic Syndrome

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Metabolic syndrome in peripheral arterial disease: relationship with severity of peripheral circulatory insufficiency, inflammatory status, and cardiovascular comorbidity

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