Cited by 447Mitochondrial Function and PathologyChronic Kidney Disease and DiabetesAutophagy in Disease and Therapy

The hallmarks of mitochondrial dysfunction in chronic kidney disease

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Galvan, Daniel L., Green, Nathanael H., Danesh, Farhad R.·2017·Kidney International

Abstract

Recent advances have led to a greater appreciation of how mitochondrial dysfunction contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received increasing attention as a therapeutic target in a variety of diseases because they serve as key regulatory hubs uniquely situated at crossroads between multiple cellular processes. This review provides an overview of the role of mitochondrial dysfunction in chronic kidney disease, with special emphasis on its role in the development of diabetic nephropathy. We examine the current understanding of the molecular mechanisms that cause mitochondrial dysfunction in the kidney and describe the impact of mitochondrial damage on kidney function. The new concept that mitochondrial shape and structure are closely linked with its function in the kidneys is discussed. Furthermore, the mechanisms that translate cellular cues and demands into mitochondrial remodeling and cellular damage, including the role of microRNAs and long noncoding RNAs, are examined with the final goal of identifying mitochondrial targets to improve treatment of patients with chronic kidney diseases.

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Authors
Galvan, D. L., Green, N. H., & Danesh, F. R.
Affiliations
  • The University of Texas MD Anderson Cancer Center (US)
  • Baylor College of Medicine (US)
Corresponding author
Danesh, Farhad R.
Venue
Kidney International
Publisher
Elsevier BV
Published
2017-11
Volume
92
Issue
5
Pages
1051-1057
ISSN
0085-2538 (ISSN-L)
OpenAlex
W2751635377
Cited by
447
References
42
Citations by year
2026: 42 · 2025: 47 · 2024: 51 · 2023: 66 · 2022: 71 · 2021: 63 · 2020: 55 · 2019: 37 · 2018: 13 · 2017: 1
FWCI
2.71
Type
journal article
Language
en
Open access
Locations
  • Kidney International (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078900, R01DK091310)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondrial dysfunction, chronic kidney disease, diabetic nephropathy, mitochondrial morphology, mitochondrial remodeling, microRNA, long non-coding RNA, renal function, therapeutic target
MeSH terms
Animals, Diabetic Nephropathies, Humans, Kidney, Mitochondria, Oxidative Stress, MicroRNAs, Renal Insufficiency, Chronic, RNA, Long Noncoding, Mitochondrial Dynamics

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