The hallmarks of mitochondrial dysfunction in chronic kidney disease
Open accessAbstract
Recent advances have led to a greater appreciation of how mitochondrial dysfunction contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received increasing attention as a therapeutic target in a variety of diseases because they serve as key regulatory hubs uniquely situated at crossroads between multiple cellular processes. This review provides an overview of the role of mitochondrial dysfunction in chronic kidney disease, with special emphasis on its role in the development of diabetic nephropathy. We examine the current understanding of the molecular mechanisms that cause mitochondrial dysfunction in the kidney and describe the impact of mitochondrial damage on kidney function. The new concept that mitochondrial shape and structure are closely linked with its function in the kidneys is discussed. Furthermore, the mechanisms that translate cellular cues and demands into mitochondrial remodeling and cellular damage, including the role of microRNAs and long noncoding RNAs, are examined with the final goal of identifying mitochondrial targets to improve treatment of patients with chronic kidney diseases.
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The causative role of oxidative stress in kidney diseases has been confirmed in diabetic nephropathy.
“The causative role of oxidative stress in kidney diseases has been confirmed in kidney damage and associated complications caused by type 1 and type 2 diabetes (diabetic nephropathy).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Galvan et al. 2017
Mitochondrial dysfunction has been documented by functional changes in kidney mitochondria.
“Mitochondrial dysfunction has been documented by functional changes in the kidney mitochondria (Galvan et al. 2017).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Galvan et al. 2017
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
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- Authors
- Galvan, D. L., Green, N. H., & Danesh, F. R.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- Corresponding author
- Danesh, Farhad R.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 92
- Issue
- 5
- Pages
- 1051-1057
- ISSN
- 0085-2538 (ISSN-L)
- PMC
- PMC5667560
- OpenAlex
- W2751635377
- Cited by
- 447
- References
- 42
- Citations by year
- 2026: 42 · 2025: 47 · 2024: 51 · 2023: 66 · 2022: 71 · 2021: 63 · 2020: 55 · 2019: 37 · 2018: 13 · 2017: 1
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078900, R01DK091310)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial dysfunction, chronic kidney disease, diabetic nephropathy, mitochondrial morphology, mitochondrial remodeling, microRNA, long non-coding RNA, renal function, therapeutic target
- MeSH terms
- Animals, Diabetic Nephropathies, Humans, Kidney, Mitochondria, Oxidative Stress, MicroRNAs, Renal Insufficiency, Chronic, RNA, Long Noncoding, Mitochondrial Dynamics
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