The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment
Open accessAbstract
Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is difficult because by the time patients seek medical attention, most have already developed acute kidney injury. Thus, early recognition is crucial to provide supportive treatment and limit further insults. Current diagnostic criteria for acute kidney injury has limited early detection; however, novel biomarkers of kidney stress and damage have been recently validated for risk prediction and early diagnosis of acute kidney injury in the setting of sepsis. Recent evidence shows that microvascular dysfunction, inflammation, and metabolic reprogramming are 3 fundamental mechanisms that may play a role in the development of S-AKI. However, more mechanistic studies are needed to better understand the convoluted pathophysiology of S-AKI and to translate these findings into potential treatment strategies and add to the promising pharmacologic approaches being developed and tested in clinical trials.
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Gupta, A., Madhavan, M. V., Sehgal, K., Nair, N., Mahajan, S., Sehrawat, T. S., Bikdeli, B., Ahluwalia, N., Ausiello, J. C., Wan, E. Y., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0968-3 · Cited by 3,185
Li, S., Dou, R., Song, X., Lui, K., Xu, J., Guo, Z., Hu, X., Guan, X., & Cai, C. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12030915 · Cited by 25
Metadata
- Authors
- Peerapornratana, S., Manrique-Caballero, C. L., Gómez, H., & Kellum, J. A.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 96
- Issue
- 5
- Pages
- 1083-1099
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2950811882
- Cited by
- 1,471
- References
- 17
- FWCI
- 79.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Peerapornratana, S., Manrique-Caballero, C. L., Gómez, H., & Kellum, J. A. (2019). Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney International. https://doi.org/10.1016/j.kint.2019.05.026
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
