The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The search for the palmitoylethanolamide receptor
Open accessAbstract
Palmitoylethanolamide (PEA), the naturally occurring amide of ethanolamine and palmitic acid, is an endogenous lipid that modulates pain and inflammation. Although the anti-inflammatory effects of PEA were first characterized nearly 50 years ago, the identity of the receptor mediating these actions has long remained elusive. We recently identified the ligand-activated transcription factor, peroxisome proliferator-activated receptor-alpha (PPAR-alpha), as the receptor mediating the anti-inflammatory actions of this lipid amide. Here we outline the history of PEA, starting with its initial discovery in the 1950s, and discuss the pharmacological properties of this compound, particularly in regards to its ability to activate PPAR-alpha.
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Cites
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Self-citationThe PPARα–leukotriene B4 pathway to inflammation control
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Cited by
Cannabinoid and cannabinoid‐like receptors in microglia, astrocytes, and astrocytomas
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An update on PPAR activation by cannabinoids
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Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism
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Self-citationCB2receptors in the brain: role in central immune function
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Metadata
- Authors
- LoVerme, J., La Rana, G., Russo, R., Calignano, A., & Piomelli, D.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 77
- Issue
- 14
- Pages
- 1685-1698
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W1968917850
- Cited by
- 248
- References
- 9
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- green
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- LoVerme, J., La Rana, G., Russo, R., Calignano, A., & Piomelli, D. (2005). The search for the palmitoylethanolamide receptor. Life Sciences. https://doi.org/10.1016/j.lfs.2005.05.012
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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