Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide

Molecular Cloning: A Laboratory Manual

Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633 · see citing works

Molecular characterization of a peripheral receptor for cannabinoids

Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092 · see citing works

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011 · see citing works

Determination and characterization of a cannabinoid receptor in rat brain

Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · see citing works

Inflammation. Basic principles and clinical correlates

(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90156-x · Cited by 2,388 · see citing works

Cannabinoid receptor localization in brain.

Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321 · see citing works

Manual of pharmacologic calculations with computer programs

(1988) · International Journal of Biochemistry · doi:10.1016/0020-711x(88)90084-5 · Cited by 1,458 · see citing works

Mast cells

Marshall, J., & Bienenstock, J. (2004) · Springer Seminars in Immunopathology · doi:10.1007/bf00197505 · Cited by 1,307 · see citing works

Mast cells as a source of multifunctional cytokines

Gordon, J., Burd, P. R., & Galli, S. J. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90176-a · Cited by 700 · see citing works

Molecular cloning of a human cannabinoid receptor which is also expressed in testis

Gérard, C. M., Mollereau, C., Vassart, G., & Parmentier, M. (1991) · Biochemical Journal · doi:10.1042/bj2790129 · Cited by 688 · see citing works

Mast cells synthesize, store, and release nerve growth factor.

Léon, A., Buriani, A., Toso, R. D., Fabris, M., Romanello, S., Aloe, L., & Levi‐Montalcini, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3739 · Cited by 669 · see citing works

IgE‐induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clones

Barsumian, E. L., Isersky, C., Petrino, M. G., & Siraganian, R. P. (1981) · European Journal of Immunology · doi:10.1002/eji.1830110410 · Cited by 575 · see citing works

Health aspects of cannabis

Hollister, L. E. (1987) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(87)90030-4 · Cited by 499 · see citing works

Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.

Felder, C. C., Briley, E. M., Axelrod, J., Simpson, J. T., Mackie, K., & Devane, W. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7656 · Cited by 478 · see citing works

Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent

Fride, E., & Mechoulam, R. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90468-w · Cited by 453 · see citing works

The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.

Smith, P. B., Compton, D. M., Welch, S. P., Razdan, R. K., Mechoulam, R., & Martin, B. R. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22356-4 · Cited by 394 · see citing works

Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.

Ozawa, K., Szállási, Z., Kazanietz, M. G., Blumberg, P. M., Mischak, H., Mushinski, J. F., & Beaven, M. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53916-8 · Cited by 366 · see citing works

Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor

Hanus, L. O., Gopher, A., Almog, S., & Mechoulam, R. (1993) · Journal of Medicinal Chemistry · doi:10.1021/jm00072a026 · Cited by 334 · see citing works

Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: implications for receptor-mediated immune modulation by cannabinoids.

Lynn, A. B., & Herkenham, M. A. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38654-4 · Cited by 278 · see citing works

The Receptor with High Affinity for IgE

Metzger, H. (1992) · Immunological Reviews · doi:10.1111/j.1600-065x.1992.tb00624.x · Cited by 263 · see citing works

[1] Statistical analysis of radioligand assay data

Rodbard, D., & Frazier, G. R. (1975) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(75)37003-1 · Cited by 248 · see citing works

Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation.

Kaminski, N. E., Abood, M. E., Kessler, F. K., Martin, B. R., & Schatz, A. R. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09130-8 · Cited by 248 · see citing works

Basophils and Mast Cells: Morphologic Insights into Their Biology, Secretory Patterns, and Function1

Galli, S. J., Dvořàk, A. M., & Dvorak, H. F. (2015) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000408370 · Cited by 239 · see citing works

Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents

Crawley, J. N., Corwin, R. L., Robinson, J. K., Felder, C. C., Devane, W. A., & Axelrod, J. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90230-q · Cited by 231 · see citing works

Homology of the rat basophilic leukemia cell and the rat mucosal mast cell.

Seldin, D. C., Adelman, S., Austen, K. F., Stevens, R. L., Hein, A., CAULFIELD, J. P., & Woodbury, R. G. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.11.3871 · Cited by 230 · see citing works

A proposed autacoid mechanism controlling mastocyte behaviour

Aloe, L., Leon, A., & Levi‐Montalcini, R. (1993) · Inflammation Research · doi:10.1007/bf01972748 · Cited by 209 · see citing works

Activation of rat peritoneal mast cells by substance P and mastoparan.

Mousli, M., Bronner, C., Bueb, J., Tschirhart, E. J., Gies, J., & Landry, Y. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21370-2 · Cited by 196 · see citing works

The role of mast cells in inflammatory processes: evidence for nerve/mast cell interactions

Bienenstock, J., Tomioka, M., Matsuda, H., Stead, R. H., Quinonez, G., Simon, G. T., Coughlin, M. D., & Denburg, J. A. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000234197 · Cited by 193 · see citing works

IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells.

Park, D. J., Min, H. K., & Rhee, S. G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54217-4 · Cited by 184 · see citing works

Effects of anandamide on cannabinoid receptors in rat brain membranes

Childers, S. R., Sexton, T., & Roy, M. B. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90134-1 · Cited by 176 · see citing works

Antigen-induced Secretion of Histamine and the Phosphorylation of Myosin by Protein Kinase C in Rat Basophilic Leukemia Cells

Ludowyke, R. I., Peleg, I., Beaven, M. A., & Adelstein, R. S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63885-2 · Cited by 159 · see citing works

N-acylation of ethanolamine phospholipids in canine myocardium

Natarajan, V., Reddy, P. V., Schmid, P. C., & Schmid, H. H. O. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90352-6 · Cited by 140 · see citing works

Health aspects of cannabis.

Hollister, L. E. (1986) · PubMed · Cited by 130 · see citing works

Interactions of mast cells with the nervous system ?Recent advances

Johnson, D. K., & Krenger, W. (1992) · Neurochemical Research · doi:10.1007/bf00993271 · Cited by 116 · see citing works

Signal Transduction and Cellular Response in RBL-2H3 Mast Cells

Oliver, J. M., Seagrave, J., Stump, R. F., Pfeiffer, J. R., & Deanin, G. G. (2015) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000415508 · Cited by 103 · see citing works

Synthetic nonpsychotropic cannabinoids with potent antiinflammatory, analgesic, and leukocyte antiadhesion activities

BURSTEIN, S. H., Audette, C. A., Breuer, A., Devane, W. A., Colodner, S., Doyle, S. A., & Mechoulam, R. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00095a007 · Cited by 99 · see citing works

High-affinity IgE receptor-mediated stimulation of rat basophilic leukemia (RBL-2H3) cells induces early and late protein-tyrosine phosphorylations.

Benhamou, M., Stephan, V., Robbins, K. C., & Siraganian, R. P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42520-3 · Cited by 89 · see citing works

Membrane Phosphoinositide-Activated Signals in Mast Cells and Basophils1

Beaven, M. A., & Cunha-Melo, J. R. (2015) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000415507 · Cited by 88 · see citing works

Fixation and staining of granules in mucosal mast cells and intraepithelial lymphocytes in the rat jejunum, with special reference to the relationship between the acid glycosaminoglycans in the two cell types

Mayrhofer, G. (1980) · The Histochemical Journal · doi:10.1007/bf01011925 · Cited by 65 · see citing works

Phospholipase participation in cannabinoid-induced release of free arachidonic acid

BURSTEIN, S. H., Budrow, J., Debatis, M. E., Hunter, S. A., & Subramanian, A. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90163-5 · Cited by 59 · see citing works

Antipyretic, analgesic and anti-inflammatory effects of Δ9-tetrahydrocannabinol in the rat

Kosersky, D. S., Dewey, W. L., & Harris, L. S. (1973) · European Journal of Pharmacology · doi:10.1016/0014-2999(73)90107-6 · Cited by 53 · see citing works

Anti-inflammatory properties of N(2-hydroxyethyl) palmitamide.

Perlík, F., Rašková, H., & Elis, J. (1971) · PubMed · Cited by 31 · see citing works

International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors

Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819 · see citing works

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125 · see citing works

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

Pertwee, R. G., Howlett, A. C., Abood, M. E., Alexander, S. P. H., Marzo, V. D., Elphick, M. R., Greasley, P. J., Hansen, H. S., Kunos, G., Mackie, K., et al. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.003004 · Cited by 1,610 · see citing works

Role of Endogenous Cannabinoids in Synaptic Signaling

Freund, T. F., Katona, I., & Piomelli, D. (2003) · Physiological Reviews · doi:10.1152/physrev.00004.2003 · Cited by 1,567 · see citing works

Pharmacology of cannabinoid CB1 and CB2 receptors

Pertwee, R. G. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)82001-3 · Cited by 1,489 · see citing works

Control of pain initiation by endogenous cannabinoids

Calignano, A., Rana, G. L., Giuffrida, A., & Piomelli, D. (1998) · Nature · doi:10.1038/28393 · Cited by 1,055 · see citing works

The neurobiology of itch

Ikoma, A., Steinhoff, M. S., Ständer, S., Yosipovitch, G., & Schmelz, M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1950 · Cited by 962 · see citing works

The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide

Lo Verme, J., Fu, J., Astarita, G., La Rana, G., Russo, R., Calignano, A., & Piomelli, D. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.006353 · Cited by 882 · see citing works

Cannabinoid CB2 receptors: immunohistochemical localization in rat brain

Gong, J.-P., Onaivi, E. S., Ishiguro, H., Liu, Q.-R., Tagliaferro, P. A., Brusco, A., & Uhl, G. R. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.035 · Cited by 820 · see citing works

Dopamine activation of endogenous cannabinoid signaling in dorsal striatum

Giuffrida, A., Parsons, L. H., Kerr, T. M., de Fonseca, F. R., Navarro, M. A., & Piomelli, D. (1999) · Nature Neuroscience · doi:10.1038/7268 · Cited by 771 · see citing works

Cannabinoid receptors and pain

Pertwee, R. G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00031-9 · Cited by 741 · see citing works

Nerve growth factor: from neurotrophin to neurokine

Levi‐Montalcini, R., Skaper, S. D., Toso, R. D., Petrelli, L., & Leon, A. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10058-8 · Cited by 684 · see citing works

Endocannabinoid signaling at the periphery: 50 years after THC

Maccarrone, M., Bab, I., Bı́ró, T., Cabral, G. A., Dey, S. K., Marzo, V. D., Konje, J. C., Kunos, G., Mechoulam, R., Pacher, P., et al. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.02.008 · Cited by 648 · see citing works

An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity

Ben‐Shabat, S., Fride, E., Sheskin, T., Tamiri, T., Rhee, M. H., Vogel, Z., Bisogno, T., PETROCELLIS, L. D., Marzo, V. D., & Mechoulam, R. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00392-6 · Cited by 626 · see citing works

Discovery of the Presence and Functional Expression of Cannabinoid CB2 Receptors in Brain

Onaivi, E. S., Ishiguro, H., GONG, J., Sejal, P., Perchuk, A., Meozzi, P. A., MYERS, L., Mora, Z., Tagliaferro, P. A., Gardner, E., et al. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1369.052 · Cited by 546 · see citing works

CB ₂ cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

Ibrahim, M. M., Porreca, F., Lai, J., Albrecht, P. J., Rice, F. L., Khodorova, A., Davar, G., Makriyannis, A., Vanderah, T. W., Mata, H. P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409888102 · Cited by 521 · see citing works

Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors

Richardson, J. D., Kilo, S., & Hargreaves, K. (1998) · Pain · doi:10.1016/s0304-3959(97)00213-3 · Cited by 498 · see citing works

Activation of CB ₂ cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

Ibrahim, M. M., Deng, H., Zvonok, A., Cockayne, D. A., Kwan, J., Mata, H. P., Vanderah, T. W., Lai, J., Porreca, F., Makriyannis, A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834309100 · Cited by 491 · see citing works

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

Skaper, S. D., Facci, L., Zusso, M., & Giusti, P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00072 · Cited by 461 · see citing works

Endocannabinoids

Mechoulam, R., Fride, E., & Marzo, V. D. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00649-9 · Cited by 431 · see citing works

Molecular characterization of human and mouse fatty acid amide hydrolases

Giang, D. K., & Cravatt, B. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2238 · Cited by 429 · see citing works

Cannabinoid CB ₂ receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain

Guindon, J., & Hohmann, A. G. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707531 · Cited by 423 · see citing works

Cannabinoids and Pain: New Insights From Old Molecules

Vuckovic, S. M., Srebro, D., Vujović, K. S., Vučetić, Č., & Prostran, M. S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01259 · Cited by 417 · see citing works

The neurobiology and evolution of cannabinoid signalling

Elphick, M. R., & Egertová, M. (2001) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0787 · Cited by 416 · see citing works

The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation

PETROCELLIS, L. D., Melck, D. J., Palmisano, A., Bisogno, T., Laezza, C., Bifulco, M., & Marzo, V. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8375 · Cited by 412 · see citing works

Emerging role of the cannabinoid receptor CB ₂ in immune regulation: therapeutic prospects for neuroinflammation

Cabral, G. A., & Griffin-Thomas, L. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409000957 · Cited by 408 · see citing works

Occurrence and Biosynthesis of Endogenous Cannabinoid Precursor,N-Arachidonoyl Phosphatidylethanolamine, in Rat Brain

Cadas, H., di Tomaso, E., & Piomelli, D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-04-01226.1997 · Cited by 394 · see citing works

CB2 cannabinoid receptor-mediated peripheral antinociception

Malan, P. T., Ibrahim, M. M., Deng, H., Liu, Q., Mata, H. P., Vanderah, T., Porreca, F., & Makriyannis, A. (2001) · Pain · doi:10.1016/s0304-3959(01)00321-9 · Cited by 391 · see citing works

The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons.

Skaper, S. D., Buriani, A., Toso, R. D., Petrelli, L., Romanello, S., Facci, L., & Léon, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3984 · Cited by 374 · see citing works

Endocannabinoid 2-Arachidonyl Glycerol Is a Full Agonist through Human Type 2 Cannabinoid Receptor: Antagonism by Anandamide

Gonsiorek, W., Lunn, C. A., Fan, X., Narula, S. K., Lundell, D. J., & Hipkin, R. W. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)26516-0 · Cited by 370 · see citing works

Evidence That 2-Arachidonoylglycerol but Not N-Palmitoylethanolamine or Anandamide Is the Physiological Ligand for the Cannabinoid CB2 Receptor

Sugiura, T., Kondo, S., Kishimoto, S., Miyashita, T., Nakane, S., Kodaka, T., Suhara, Y., Takayama, H., & Waku, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.605 · Cited by 370 · see citing works

Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes

Bisogno, T., Maurelli, S., Melck, D. J., PETROCELLIS, L. D., & Marzo, V. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3315 · Cited by 367 · see citing works

Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders

Iannotti, F. A., Marzo, V. D., & Petrosino, S. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.02.002 · Cited by 357 · see citing works

The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain

Jaggar, S., Hasnie, F. S., Sellaturay, S., & Rice, A. S. C. (1998) · Pain · doi:10.1016/s0304-3959(98)00041-4 · Cited by 351 · see citing works

The Endocannabinoid System: Drug Targets, Lead Compounds, and Potential Therapeutic Applications

Lambert, D. M., & Fowler, C. J. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm058183t · Cited by 350 · see citing works

Naturally occurring antinociceptive substances from plants

Calixto, J. Β., Beirith, A., Ferreira, J., Santos, A. R. S., Filho, V. C., & Yunes, R. A. (2000) · Phytotherapy Research · doi:10.1002/1099-1573(200009)14:6 · Cited by 340 · see citing works

N-(2-Hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation

Mazzari, S., Canella, R., Petrelli, L., Marcolongo, G., & Leon, A. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00015-5 · Cited by 334 · see citing works

The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations

Petrosino, S., & Marzo, V. D. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13580 · Cited by 333 · see citing works

Molecular Characterization of N-Acylethanolamine-hydrolyzing Acid Amidase, a Novel Member of the Choloylglycine Hydrolase Family with Structural and Functional Similarity to Acid Ceramidase

Tsuboi, K., Sun, Y.-X., Okamoto, Y., Araki, N., Tonai, T., & Ueda, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413473200 · Cited by 328 · see citing works

Biosynthesis of an Endogenous Cannabinoid Precursor in Neurons and its Control by Calcium and cAMP

Cadas, H., Gaillet, S., Beltramo, M., Venance, L., & Piomelli, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-12-03934.1996 · Cited by 318 · see citing works

‘Endocannabinoids’ and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance

Marzo, V. D. (1998) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(98)00042-3 · Cited by 310 · see citing works

Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside

Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works

The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain

Klauke, A. ‐., Rácz, I., Pradier, B., Markert, A., Zimmer, A., Gertsch, J., & Zimmer, A. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.10.008 · Cited by 303 · see citing works

Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin

Ständer, S., Schmelz, M., Metze, D., Luger, T. A., & Rukwied, R. (2005) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2005.01.007 · Cited by 300 · see citing works

Immune Responses Regulated by Cannabidiol

Nichols, J. M., & Kaplan, B. L. F. (2019) · Cannabis and Cannabinoid Research · doi:10.1089/can.2018.0073 · Cited by 297 · see citing works

Cannabinoid receptors and the regulation of immune response

Berdyshev, E. V. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00195-x · Cited by 280 · see citing works

Structural Requirements for Binding of Anandamide-Type Compounds to the Brain Cannabinoid Receptor

Sheskin, T., Hanuš, L., Slager, J., Vogel, Z., & Mechoulam, R. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm960752x · Cited by 274 · see citing works

Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells

Bisogno, T., Sepe, N., Melck, D. J., Maurelli, S., PETROCELLIS, L. D., & Marzo, V. D. (1997) · Biochemical Journal · doi:10.1042/bj3220671 · Cited by 273 · see citing works

Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases?

Croxford, J. L., & Yamamura, T. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.04.023 · Cited by 256 · see citing works

Biphasic Effects of Anandamide

Sulcova, E. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00422-x · Cited by 256 · see citing works

Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation

Izzo, A. A., Fezza, F., Capasso, R., Bisogno, T., Pinto, L., Iuvone, T., Esposito, G., Mascolo, N., Marzo, V. D., & Capasso, F. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704293 · Cited by 255 · see citing works

Mast cells, glia and neuroinflammation: partners in crime?

Skaper, S. D., Facci, L., & Giusti, P. (2013) · Immunology · doi:10.1111/imm.12170 · Cited by 251 · see citing works

The search for the palmitoylethanolamide receptor

LoVerme, J., Rana, G. L., Russo, R., Calignano, A., & Piomelli, D. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.012 · Cited by 249 · see citing works

Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid‐type CB2 receptor

Klegeris, A., Bissonnette, C. J., & McGeer, P. L. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705304 · Cited by 244 · see citing works

Cannabinoids and the immune system: An overview

Tănăsescu, R., & Constantinescu, C. S. (2010) · Immunobiology · doi:10.1016/j.imbio.2009.12.005 · Cited by 243 · see citing works

Purification and Characterization of an Acid Amidase Selective for N-Palmitoylethanolamine, a Putative Endogenous Anti-inflammatory Substance

Ueda, N., Yamanaka, K., & Yamamoto, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106261200 · Cited by 242 · see citing works

Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide

Calignano, A., Rana, G. L., & Piomelli, D. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00988-8 · Cited by 241 · see citing works

Therapeutic Potential of Cannabinoids in CNS Disease

Croxford, J. L. (2003) · CNS Drugs · doi:10.2165/00023210-200317030-00004 · Cited by 240 · see citing works

Mast cells in neuroinflammation and brain disorders

Hendriksen, E., van Bergeijk, D. A., Oosting, R. S., & Redegeld, F. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.001 · Cited by 240 · see citing works

Microglia and mast cells: two tracks on the road to neuroinflammation

Skaper, S. D., Giusti, P., & Facci, L. (2012) · The FASEB Journal · doi:10.1096/fj.11-197194 · Cited by 235 · see citing works

Pharmacological characterization of GPR55, a putative cannabinoid receptor

Sharir, H., & Abood, M. E. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.02.004 · Cited by 234 · see citing works

Endocannabinoids and immune regulation☆

Pandey, R., Mousawy, K. M., Nagarkatti, M., & Nagarkatti, P. S. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.03.019 · Cited by 232 · see citing works

N-Acylethanolamines in human reproductive fluids

Schuel, H., Burkman, L. J., Lippes, J., Crickard, K., Forester, E., Piomelli, D., & Giuffrida, A. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00158-5 · Cited by 232 · see citing works

2-Arachidonoylglycerol and the cannabinoid receptors

Sugiura, T., & Waku, K. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00189-4 · Cited by 231 · see citing works

Amygdala FAAH and anandamide: mediating protection and recovery from stress

Gunduz-Cinar, O., Hill, M. N., McEwen, B. S., & Holmes, A. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.08.008 · Cited by 229 · see citing works

Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development

Pertwee, R. G. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.7.1553 · Cited by 228 · see citing works

Adjuvant treatment of atopic eczema: assessment of an emollient containing N‐palmitoylethanolamine (ATOPA study)

Eberlein, B., Eicke, C., Reinhardt, H., & Ring, J. (2007) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2007.02351.x · Cited by 227 · see citing works

The endocannabinoid nervous system

Porter, A. C., & Felder, C. C. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00130-9 · Cited by 226 · see citing works

Localization of cannabinoid CB1 receptors in the human anterior eye and retina.

Straiker, A. J., Maguire, G., Mackie, K., & Lindsey, J. D. (1999) · PubMed · Cited by 225 · see citing works

CB cannabinoid receptor agonists: pain relief without psychoactive effects?

MALANJR, T., IBRAHIM, M., LAI, J., Vanderah, T. W., Makriyannis, A., & Porreca, F. (2003) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00004-8 · Cited by 223 · see citing works

N-Acylethanolamines and precursor phospholipids — relation to cell injury

Hansen, H. S., Moesgaard, B., Hansen, H. H., & Petersen, G. L. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00192-4 · Cited by 222 · see citing works

Cannabinoids as therapeutic agents in cancer: current status and future implications

Chakravarti, B., Ravi, J., & Ganju, R. K. (2014) · Oncotarget · doi:10.18632/oncotarget.2233 · Cited by 219 · see citing works

Cannabinoid signaling in glial cells

Stella, N. (2004) · Glia · doi:10.1002/glia.20084 · Cited by 218 · see citing works

Cannabis in cancer care

Abrams, D., & Guzmán, M. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.108 · Cited by 217 · see citing works

The Cannabinoid System and Cytokine Network

Klein, T., Lane, B., Newton, C. A., & Friedman, H. P. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22501.x · Cited by 216 · see citing works

Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells

Marzo, V. D., Melck, D. J., Orlando, P., Bisogno, T., Zagoory, O., Bifulco, M., Vogel, Z., & PETROCELLIS, L. D. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580249 · Cited by 212 · see citing works

Cannabinoid CB1 receptors and ligands in vertebrate retina: Localization and function of an endogenous signaling system

Straiker, A. J., Stella, N., Piomelli, D., Mackie, K., Karten, H. J., & Maguire, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14565 · Cited by 211 · see citing works

Activational role of cannabinoids on movement

Sañudo-Peña, M. C., Romero, J., Seale, G. E., Fernández‐Ruíz, J., & Walker, J. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00044-3 · Cited by 211 · see citing works

Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

Tóth, K. F., Ádám, D., Bı́ró, T., & Oláh, A. (2019) · Molecules · doi:10.3390/molecules24050918 · Cited by 209 · see citing works

Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity

Wallace, M. J., Martin, B. R., & DeLorenzo, R. J. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02331-2 · Cited by 208 · see citing works

Cloning and Pharmacological Characterization of the Rat CB2 Cannabinoid Receptor

Griffin, G., Tao, Q., & Abood, M. E. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35367-4 · Cited by 207 · see citing works

Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors

PETROCELLIS, L. D., Davis, J. B., & Marzo, V. D. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02934-9 · Cited by 204 · see citing works

Cannabinoid-Induced Hypotension and Bradycardia in Rats Is Mediated by CB1-Like Cannabinoid Receptors

Lake, K. D., Compton, D. R., Varga, K., Martin, B. R., & Kunos, G. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36714-x · Cited by 200 · see citing works

Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals

Re, G., Barbero, R., Miolo, A., & Di Marzo, V. (2007) · The Veterinary Journal · doi:10.1016/j.tvjl.2005.10.003 · Cited by 199 · see citing works

The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamide

Marzo, V. D., Bisogno, T., SUGIURA, T., Melck, D. J., & PETROCELLIS, L. D. (1998) · Biochemical Journal · doi:10.1042/bj3310015 · Cited by 199 · see citing works

Modulation of pain transmission by G-protein-coupled receptors

Pan, H., Wu, Z.-Z., Zhou, H.-Y., Chen, S.-R., Zhang, H., & Li, D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.003 · Cited by 197 · see citing works

Anandamide Hydrolysis by Human Cells in Culture and Brain

Maccarrone, M., van der Stelt, M., Rossi, A., Veldink, G. A., Vliegenthart, J. F. G., & Finazzi‐Agrò, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.48.32332 · Cited by 196 · see citing works

Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells

Marzo, V. D., PETROCELLIS, L. D., Sepe, N., & BUONO, A. (1996) · Biochemical Journal · doi:10.1042/bj3160977 · Cited by 195 · see citing works

Cannabinoids and Pain: Sites and Mechanisms of Action

Starowicz, K., & Finn, D. P. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.05.003 · Cited by 192 · see citing works

Cannabinoid receptors undergo axonal flow in sensory nerves

Hohmann, A. G., & Herkenham, M. A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00220-1 · Cited by 192 · see citing works

Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat

Conti, S., Costa, B., Colleoni, M., Parolaro, D., & Giagnoni, G. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704466 · Cited by 189 · see citing works

Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors

Melck, D., Bisogno, T., De Petrocellis, L., Chuang, H.-H., Julius, D., Bifulco, M., & Di Marzo, V. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1105 · Cited by 188 · see citing works

Neuropsychobiological Evidence for the Functional Presence and Expression of Cannabinoid CB2 Receptors in the Brain

Onaivi, E. S. (2006) · Neuropsychobiology · doi:10.1159/000100778 · Cited by 187 · see citing works

Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy

Rice, A. S. C., Farquhar-Smith, W. P., & Nagy, I. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0362 · Cited by 183 · see citing works

The endocannabinoid system as a target for the treatment of neurodegenerative disease

Scotter, E. L., Abood, M. E., & Glass, M. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00735.x · Cited by 181 · see citing works

Endocannabinoids as physiological regulators of colonic propulsion in mice

Pinto, L., Izzo, A. A., Mascolo, N., Capasso, F., Cascio, M. G., Bisogno, T., Marzo, V. D., Hospodar–Scott, K., & Brown, D. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.34242 · Cited by 180 · see citing works

Presence and regulation of the endocannabinoid system in human dendritic cells

Matias, I., Pochard, P., Orlando, P., Salzet, M., Pestel, J., & Marzo, V. D. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03078.x · Cited by 178 · see citing works

Modulation and Functional Involvement of CB2 Peripheral Cannabinoid Receptors During B-Cell Differentiation

Carayon, P., Marchand, J., Dussossoy, D., Derocq, J., Jbilo, O., Bord, A., Bouaboula, M., Galiègue, S., Mondière, P., Pénarier, G., et al. (1998) · Blood · doi:10.1182/blood.v92.10.3605 · Cited by 178 · see citing works

Selective activation of cannabinoid CB2 receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation

Nackley, A. G., Makriyannis, A., & Hohmann, A. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00126-x · Cited by 176 · see citing works

Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders

PETROCELLIS, L. D., Melck, D. J., Bisogno, T., & Marzo, V. D. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00196-1 · Cited by 174 · see citing works

Effects of cannabinoid receptor agonists on immunologically induced histamine release from rat peritoneal mast cells

Lau, H. Y. A., & Chow, S. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01430-4 · Cited by 34 · see citing works

New Insights in Mast Cell Modulation by Palmitoylethanolamide

Filippis, D. D., Negro, L., Vaia, M., Cinelli, M. P., & Iuvone, T. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312010013 · Cited by 33 · see citing works

Cannabinomimetic Control of Mast Cell Mediator Release: New Perspective in Chronic Inflammation

Filippis, D. D., D’Amico, A., & Iuvone, T. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01674.x · Cited by 60 · see citing works

Selective Cannabinoid Receptor-1 Agonists Regulate Mast Cell Activation in an Oxazolone-Induced Atopic Dermatitis Model

Nam, G., Jeong, S. K., Park, B. M., Lee, S. H., Kim, H. J., Hong, S.-P., Kim, B. J., & Kim, B.-W. (2016) · Annals of Dermatology · doi:10.5021/ad.2016.28.1.22 · Cited by 57 · see citing works

N-(2-Hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation

Mazzari, S., Canella, R., Petrelli, L., Marcolongo, G., & Leon, A. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00015-5 · Cited by 334 · see citing works