Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats
Open accessAbstract
Aims The effect of exercise training (ET) on vascular responsiveness in diabetes mellitus has been largely well studied. However, limited studies have investigated the effects of ET on functional responses of the corpus cavernosum (CC) in diabetic animals. Therefore, the aim of this study was to investigate whether prior ET prevents the impairment of erectile function in streptozotocin-induced diabetic rats.Main methods Rats were exercised for four weeks prior to the induction of diabetes, and then again for another 4 weeks thereafter. Concentration-response curves to acetylcholine, sodium nitroprusside, Y-27632, BAY 412272 and phenylephrine (PE) were obtained in CC. The excitatory and inhibitory effects of electrical-field stimulation were also evaluated.Key findings Plasma SOD levels were markedly decreased in the sedentary diabetic group (D-SD) as compared to control sedentary animals (C-SD), approximately 53% (P<0.05) and this reduction was restored in trained diabetic animals. Physical training restored the impairment of endothelium-dependent and -independent relaxation responses seen in the D-SD group. The potency values for Y-27632 in the CC were significantly reduced in the D-SD group, which was reversed by physical training. The impairment of electrical-field stimulation (EFS)-induced relaxation seen in the D-SD group was restored by physical training. On the other hand, both EFS-induced contractions and concentration-response curves to PE in cavernosal strips were not modified by either diabetes or physical training.Significance Practice of regular physical exercise may be an important approach in preventing erectile dysfunction associated with diabetes mellitus by re-establishment of the balance between NO production and its inactivation.
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Exercise training increased depressed plasma superoxide dismutase levels of sedentary diabetic rats.
“The exercise training increased depressed plasma superoxide dismutase (SOD) levels of sedentary diabetic rats.”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [102]
Treadmill training of diabetic rats restored impaired endothelial-dependent and neurogenic nitrergic relaxation in corpus cavernosum.
“Treadmill training of diabetic rats restored impaired endothelial-dependent and neurogenic nitrergic relaxation in corpus cavernosum (102).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [102]
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Lack of Exercise Is a Major Cause of Chronic Diseases
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- Authors
- Claudino, M. A., Delbin, M. A., Franco-Penteado, C. F., Priviero, F. B., De Nucci, G., Antunes, E., & Zanesco, A.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Corresponding author
- Zanesco, Angelina
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 88
- Issue
- 5-6
- Pages
- 272-277
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2048452593
- Cited by
- 34
- References
- 30
- Citations by year
- 2025: 1 · 2023: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 6
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- exercise training, erectile dysfunction, diabetes mellitus, corpus cavernosum, endothelial function, nitrergic relaxation, nitric oxide, superoxide dismutase, acetylcholine, sodium nitroprusside, Y-27632, electrical field stimulation, streptozotocin-induced diabetes, vascular response
- MeSH terms
- Animals, Cells, Cultured, Diabetes Mellitus, Experimental, Erectile Dysfunction, Male, Muscle Contraction, Muscle, Smooth, Penile Erection, Physical Conditioning, Animal, Rats
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