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Cited by 79Curcumin's Biomedical ApplicationsAlcohol Consumption and Health EffectsSaffron Plant Research Studies

Low doses of curcumin protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK

Lee, Hae-In, McGregor, Robin A., Choi, Myung-Sook, Seo, Kown-Il, Jung, Un Ju, Yeo, Jiyoung, Kim, Myung-Joo, Lee, Mi-Kyung·2013·Life Sciences
DOI 10.1016/j.lfs.2013.09.014
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Abstract

Aims This study investigated the hepatoprotective effects of low doses of curcumin against liver damage induced by chronic alcohol intake and a high-fat diet. We also examined several potential underlying mechanisms including action on alcohol metabolism, antioxidant activity, AMPK level and lipid metabolism.Main method Alcohol (25% v/v, 5 g/kg body weight) was orally administered once a day for 6 weeks to mice fed a high-fat diet with or without two different doses of curcumin (0.02% and 0.05%, wt/wt).Key findings Curcumin significantly decreased the plasma aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase and alkaline phosphatase activities (p<0.05) and prevented hepatic steatosis compared with the alcohol control group. Curcumin significantly reversed the alcohol-induced inhibition of the alcohol dehydrogenase, aldehyde dehydrogenase 2 and antioxidant enzyme activities as well as the activation of cytochrome P4502E1 and promotion of lipid peroxidation (p<0.05). Curcumin significantly increased the hepatic total AMPK protein level and concomitantly suppressed the fatty acid synthase and phosphatidate phosphohydrolase activities compared with the alcohol control group (p<0.05). Furthermore, curcumin significantly lowered the plasma leptin, free fatty acids and triglycerides levels and hepatic lipid levels (p<0.05).Significance These findings indicate that low doses of curcumin may protect against liver damage caused by chronic alcohol intake and a high-fat diet partly by modulating the alcohol metabolic enzyme activity, the antioxidant activity and the lipid metabolism. Therefore, curcumin may provide a promising natural therapeutic strategy against liver disease.

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  • Consumption of anti-inflammatory antioxidants from natural dietary supplements and/or synthetic origins can help reduce the incidence and severity of AGE-associated inflammation and related disorders.

    “Furthermore, consumption of anti-inflammatory antioxidants from natural dietary supplements279,281,282,290 and/or synthetic origins199 can help reduce the incidence and severity of AGE-associated inflammation and related disorders.”

    From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [282]

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Authors
Lee, H.-I., McGregor, R. A., Choi, M.-S., Seo, K.-I., Jung, U. J., Yeo, J., Kim, M.-J., & Lee, M.-K.
Affiliations
  • Sunchon National University (KR)
  • Kyungpook National University (KR)
  • Catholic University of Korea (KR)
  • Daegu Technical University (KR)
Corresponding author
Lee, Mi-Kyung
ORCID
Venue
Life Sciences
Publisher
Elsevier BV
Published
2013-11
Volume
93
Issue
18-19
Pages
693-699
ISSN
0024-3205 (ISSN-L)
DOI
10.1016/j.lfs.2013.09.014
OpenAlex
W2035332604
Cited by
79
References
39
Citations by year
2026: 1 · 2025: 3 · 2024: 8 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 8 · 2014: 7
FWCI
3.22
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Research Foundation (NRF) of Korea
  • Korean government (2012-0000644, 2012M3A9C4048818)
  • Suncheon Research Center for Natural Medicines
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Oncology › Saffron Plant Research Studies
Keywords
curcumin, hepatoprotection, alcohol-induced liver damage, chronic alcohol consumption, high-fat diet, alcohol metabolism, CYP2E1, AMPK, alcohol dehydrogenase, ALDH2, lipid peroxidation, antioxidant enzymes, hepatic steatosis, fatty acid synthase, phosphatidate phosphohydrolase, lipid metabolism, leptin, triglycerides, free fatty acids
MeSH terms
Ethanol, Animals, Curcumin, Dose-Response Relationship, Drug, Liver Diseases, Alcoholic, Male, Mice, Inbred ICR, Cytochrome P-450 CYP2E1, Mice, Metabolic Networks and Pathways, AMP-Activated Protein Kinases

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