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Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment

Ren, Tianjing, Yang, Mengbi, Xiao, Min, Zhu, Junjie, Xie, Wen, Zuo, Zhong·2019·Life Sciences
DOI 10.1016/j.lfs.2018.12.060
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  1. Dong, 2015, Piperine inhibit inflammation, alveolar bone loss and collagen fibers breakdown in a rat periodontitis model, J. Periodontal Res., 50, 758, 10.1111/jre.12262 · DOI
  2. Ma, 2014, Piperine effectively protects primary cultured atrial myocytes from oxidative damage in the infant rabbit model, Mol. Med. Rep., 10, 2627, 10.3892/mmr.2014.2554 · DOI
  3. Greenshields, 2015, Piperine inhibits the growth and motility of triple-negative breast cancer cells, Cancer Lett., 357, 129, 10.1016/j.canlet.2014.11.017 · DOI
  4. da Cruz, 2013, Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms, Pharmacol. Biochem. Behav., 104, 144, 10.1016/j.pbb.2013.01.002 · DOI
  5. 1974, Acad. J. Peking Univ. Health Sci. Cent., 214
  6. Jin, 2010, Effect of piperine, a major component of black pepper, on the intestinal absorption of fexofenadine and its implication on food-drug interaction, J. Food Sci., 75, H93, 10.1111/j.1750-3841.2010.01542.x · DOI
  7. Alhumayyd, 2014, Effect of piperine, a major component of black pepper, on the pharmacokinetics of domperidone in rats, J. Physiol. Pharmacol., 65, 785
  8. Rezaee, 2014, The effect of piperine on midazolam plasma concentration in healthy volunteers, a research on the CYP3A-involving metabolism, Daru, 22, 1, 10.1186/2008-2231-22-8 · DOI · Paper page
  9. Bano, 1991, Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers, Eur. J. Clin. Pharmacol., 41, 615, 10.1007/BF00314996 · DOI · Paper page
  10. Bhardwaj, 2002, Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4, J. Pharmacol. Exp. Ther., 302, 645, 10.1124/jpet.102.034728 · DOI · Paper page
  11. Shimada, 1997, Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans, Arch. Toxicol., 71, 401, 10.1007/s002040050403 · DOI
  12. Dalvi, 1991, Differences in the effects of piperine and piperonyl butoxide on hepatic drug-metabolizing enzyme system in rats, Drug Chem. Toxicol., 14, 219, 10.3109/01480549109017878 · DOI
  13. Bialer, 1998, Does carbamazepine have a narrow therapeutic plasma concentration range?, Ther. Drug Monit., 20, 56, 10.1097/00007691-199802000-00010 · DOI
  14. Kerr, 1994, Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation, Biochem. Pharmacol., 47, 1969, 10.1016/0006-2952(94)90071-X · DOI · Paper page
  15. Tomson, 1990, Carbamazepine-10,11-epoxide in epilepsy. A pilot study, Arch. Neurol., 47, 888, 10.1001/archneur.1990.00530080072013 · DOI
  16. Willson, 2002, PXR, CAR and drug metabolism, Nat. Rev. Drug Discov., 1, 259, 10.1038/nrd753 · DOI · Paper page
  17. Pattanaik, 2009, Pharmacokinetic interaction of single dose of piperine with steady-state carbamazepine in epilepsy patients, Phytother. Res., 23, 1281, 10.1002/ptr.2676 · DOI
  18. Bedada, 2017, Effect of piperine on the metabolism and pharmacokinetics of carbamazepine in healthy volunteers, Drug Res., 67, 46
  19. Eisenthal, 1974, The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters, Biochem. J., 139, 715, 10.1042/bj1390715 · DOI
  20. Obach, 2007, Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions, Drug Metab. Dispos., 35, 246, 10.1124/dmd.106.012633 · DOI
  21. Mayhew, 2000, An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation, Drug Metab. Dispos., 28, 1031, 10.1016/S0090-9556(24)15182-3 · DOI
  22. Fromm, 1996, Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin, Hepatology, 24, 796, 10.1002/hep.510240407 · DOI · Paper page
  23. Chang, 1985, Inhibition of epoxidation of carbamazepine by valproic acid in the isolated perfused rat liver, J. Pharmacokinet. Biopharm., 13, 453, 10.1007/BF01059329 · DOI
  24. Egnell, 2003, In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine, J. Pharmacol. Exp. Ther., 305, 1251, 10.1124/jpet.102.047530 · DOI
  25. Hill, 2003, In vitro drug metabolism using liver microsomes, Curr. Protoc. Pharmacol., 23, 7.8.1, 10.1002/0471141755.ph0708s23 · DOI
  26. Zhang, 2014, Induction of liver cytochrome P450s by Danshen-Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin, J. Ethnopharmacol., 154, 672, 10.1016/j.jep.2014.04.047 · DOI
  27. Schilter, 2000, Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers, J. Pharmacol. Exp. Ther., 294, 916, 10.1016/S0022-3565(24)39153-0 · DOI
  28. Chirulli, 2005, CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs, Life Sci., 76, 2535, 10.1016/j.lfs.2004.09.042 · DOI
  29. Kiyosawa, 2008, o,p′-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver, Toxicol. Sci., 101, 350, 10.1093/toxsci/kfm275 · DOI
  30. Xie, 2000, Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR, Genes Dev., 14, 3014, 10.1101/gad.846800 · DOI · Paper page
  31. Wang, 2010, Pharmacokinetics of piperine capsules in healthy volunteers, Central South Pharm., 8
  32. Li, 2016, Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats, J. Pharm. Biomed. Anal., 128, 286, 10.1016/j.jpba.2016.05.041 · DOI
  33. Ren, 2017, Efficient brain uptake of piperine and its pharmacokinetics characterization after oral administration, Xenobiotica, 1
  34. Zabela, 2018, GABA A receptor activity modulating piperine analogs: in vitro metabolic stability, metabolite identification, CYP450 reaction phenotyping, and protein binding, J. Chromatogr. B, 1072, 379, 10.1016/j.jchromb.2017.11.036 · DOI · Paper page
  35. Lin, 1998, Inhibition and induction of cytochrome P450 and the clinical implications, Clin. Pharmacokinet., 35, 361, 10.2165/00003088-199835050-00003 · DOI · Paper page
  36. Zhou, 2005, Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs, Clin. Pharmacokinet., 44, 279, 10.2165/00003088-200544030-00005 · DOI · Paper page
  37. Heydari, 2004, Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine, Drug Metab. Dispos., 32, 1213, 10.1124/dmd.104.001180 · DOI
  38. Uttamsingh, 2015, Altering metabolic profiles of drugs by precision deuteration: reducing mechanism-based inhibition of CYP2D6 by paroxetine, J. Pharmacol. Exp. Ther., 354, 43, 10.1124/jpet.115.223768 · DOI
  39. Kenworthy, 1999, CYP3A4 drug interactions: correlation of 10 in vitro probe substrates, Br. J. Clin. Pharmacol., 48, 716, 10.1046/j.1365-2125.1999.00073.x · DOI · Paper page
  40. Nakamura, 2003, CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids, Drug Metab. Dispos., 31, 432, 10.1124/dmd.31.4.432 · DOI
  41. Müller, 2015, Concurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulations, Biochemistry, 54, 711, 10.1021/bi5011656 · DOI
  42. Obach, 2006, The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions, J. Pharmacol. Exp. Ther., 316, 336, 10.1124/jpet.105.093229 · DOI
  43. Grime, 2009, Mechanism-based inhibition of cytochrome P450 enzymes: an evaluation of early decision making in vitro approaches and drug-drug interaction prediction methods, Eur. J. Pharm. Sci., 36, 175, 10.1016/j.ejps.2008.10.002 · DOI
  44. Soucek, 1992, Cytochromes P-450 in rats: structures, functions, properties and relevant human forms, Xenobiotica, 22, 83, 10.3109/00498259209053106 · DOI · Paper page
  45. Li, 2008, The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor, Mol. Pharmacol., 74, 443, 10.1124/mol.108.046656 · DOI
  46. Honkakoski, 2000, Regulation of cytochrome P450 (CYP) genes by nuclear receptors, Biochem. J., 347, 321, 10.1042/bj3470321 · DOI
  47. Wang, 2013, Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1, Toxicol. Appl. Pharmacol., 272, 96, 10.1016/j.taap.2013.05.014 · DOI
  48. Fountain, 2002, Treatment of epilepsy: principles and practice, Neurology, 58, 1578

Cited by

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Metadata

Authors
Ren, T., Yang, M., Xiao, M., Zhu, J., Xie, W., & Zuo, Z.
ORCID
Zuo, Zhong
Venue
Life Sciences
Publisher
Elsevier BV
Published
2019-02
Volume
218
Pages
314-323
ISSN
0024-3205
DOI
10.1016/j.lfs.2018.12.060
Cited by
17
References
1
Language
en
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CoChat. (2026). Citation check: Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment. https://app.cochat.ai/papers/10.1016/j.lfs.2018.12.060
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Ren, T., Yang, M., Xiao, M., Zhu, J., Xie, W., & Zuo, Z. (2019). Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment. Life Sciences. https://doi.org/10.1016/j.lfs.2018.12.060

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.