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Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4
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“These results confirm and extend upon a previous observation that piperine is a relatively potent inhibitor of CYP3A-mediated verapamil metabolism (Bhardwaj et al., 2002).”
From Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor (2008) · cites this paper as Bhardwaj et al., 2002
In the citing paper
“Piperine inhibits CYP3A-mediated verapamil oxidation in human liver microsomes with IC50 values ranging from 36 to 77 μM (Bhardwaj et al., 2002).”
From Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor (2008) · cites this paper as Bhardwaj et al., 2002
In the citing paper
“Piperine has been reported to inhibit the enzyme activity of cytochrome P450 (CYP) 3A4.”
From Predicting Food–Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling (2024) · cites this paper as [7]
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Research works printed but not linked: 39
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Marchetti, S., Mazzanti, R., Beijnen, J. H., & Schellens, J. H. M. (2007) · The Oncologist · doi:10.1634/theoncologist.12-8-927 · Cited by 284
Volak, L. P., Ghirmai, S., Cashman, J. R., & Court, M. H. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.020552 · Cited by 214
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Lewandowska, U., Szewczyk, K., Hrabec, E., Janecka, A., & Gorlach, S. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404439b · Cited by 196
Gurley, B., Fifer, E., & Gardner, Z. (2012) · Planta Medica · doi:10.1055/s-0031-1298331 · Cited by 165
Heikkinen, A. T., Baneyx, G., Caruso, A., & Parrott, N. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.06.013 · Cited by 76
Metadata
- Authors
- Bhardwaj, R. K., Glaeser, H., Becquemont, L., Klotz, U., Gupta, S. K., & Fromm, M. F.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 302
- Issue
- 2
- Pages
- 645-650
- ISSN
- 0022-3565
- Cited by
- 444
- References
- 0
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
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- CoChat. (2026). Citation check: Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4. https://app.cochat.ai/papers/10.1124/jpet.102.034728
- The paper
- Bhardwaj, R. K., Glaeser, H., Becquemont, L., Klotz, U., Gupta, S. K., & Fromm, M. F. (2002). Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1124/jpet.102.034728
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