The DOI matches its Crossref record; 255 of the 255 references it cites were found in a registry or an index.
Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis
Open accessAbstract
Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1.14) is the first and rate-limiting enzyme in the classic bile acid synthesis pathway. Much progress has been made in understanding the transcriptional regulation of CYP7A1 gene expression and the underlying molecular mechanisms of bile acid feedback regulation of CYP7A1 and bile acid synthesis in the last three decades. Discovery of bile acid-activated receptors and their roles in the regulation of lipid, glucose and energy metabolism have been translated to the development of bile acid-based drug therapies for the treatment of liver-related metabolic diseases such as alcoholic and non-alcoholic fatty liver diseases, liver cirrhosis, diabetes, obesity and hepatocellular carcinoma. This review will provide an update on the advances in our understanding of the molecular biology and mechanistic insights of the regulation of CYP7A1 in bile acid synthesis in the last 40 years.
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1 retracted
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Cited by
Fukushima, K., & Pollock, D. D. (2023) · Nature Ecology & Evolution · doi:10.1038/s41559-022-01932-7 · Cited by 55
Marian, O. C., Teo, J. D., Lee, J. Y., Song, H., Kwok, J. B., Landin-Romero, R., Halliday, G., & Don, A. S. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01544-7 · Cited by 50
Gallucci, G. M., Hayes, C. M., Boyer, J. L., Barbier, O., Assis, D. N., & Ghonem, N. S. (2024) · Cells · doi:10.3390/cells13151296 · Cited by 40
Aghadi, M., Elgendy, R., & Abdelalim, E. M. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05158-0 · Cited by 36
Cingolani, F., Liu, Y., Shen, Y., Wen, J., Farris, A. B., & Czaja, M. J. (2022) · Hepatology Communications · doi:10.1002/hep4.1867 · Cited by 18
Metadata
- Authors
- Chiang, J. Y. L., & Ferrell, J. M.
- Venue
- Liver Research
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 4
- Issue
- 2
- Pages
- 47-63
- ISSN
- 2096-2878 (ISSN-L)
- 2542-5684
- OpenAlex
- W3033814839
- Cited by
- 294
- References
- 255
- FWCI
- 20.95
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Chiang, J. Y. L., & Ferrell, J. M. (2020). Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis. Liver Research. https://doi.org/10.1016/j.livres.2020.05.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
