Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

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Identification of membrane-type receptor for bile acids (M-BAR)

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Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

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Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System

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Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

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Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD

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Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

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Bile acids as regulatory molecules

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The bile acid receptor FXR is a modulator of intestinal innate immunity

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Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

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Functional Consequences of Cysteine Modification in the Ligand Binding Sites of Peroxisome Proliferator Activated Receptors by GW9662

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Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders

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Interactions between gut bacteria and bile in health and disease

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Bile acid nuclear receptor FXR and digestive system diseases

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The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

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Molecular physiology of bile acid signaling in health, disease, and aging

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Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

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The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

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Human Insulin Resistance Is Associated With Increased Plasma Levels of 12α-Hydroxylated Bile Acids

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Expression and function of the bile acid receptor TGR5 in Kupffer cells

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Bile Acids as Hormones: The FXR-FGF15/19 Pathway

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FXR: a metabolic regulator and cell protector

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Small metabolites, possible big changes: A microbiota-centered view of non-alcoholic fatty liver disease

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Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

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FXR, a multipurpose nuclear receptor

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A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis

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Bile acids as endogenous etiologic agents in gastrointestinal cancer

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Inhibiting the Initiation of <i>Clostridium difficile</i> Spore Germination using Analogs of Chenodeoxycholic Acid, a Bile Acid

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Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice

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Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

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Bile acid signaling pathways from the enterohepatic circulation to the central nervous system

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Bile acids are nutrient signaling hormones

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Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis

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Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

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Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

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New therapeutic concepts in bile acid transport and signaling for management of cholestasis

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Metabolic Messengers: bile acids

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Intestinal absorption of bile acids in health and disease

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Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

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The biosynthesis, signaling, and neurological functions of bile acids

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Novel therapeutic targets for cholestatic and fatty liver disease

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Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway

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D3R grand challenge 2: blind prediction of protein–ligand poses, affinity rankings, and relative binding free energies.

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The Human Apolipoprotein AV Gene Is Regulated by Peroxisome Proliferator-activated Receptor-α and Contains a Novel Farnesoid X-activated Receptor Response Element

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Host genotype and gut microbiome modulate insulin secretion and diet-induced metabolic phenotypes

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The bile acid membrane receptor TGR5: a valuable metabolic target

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Molecular basis of bile acid-FXR-FGF15/19 signaling axis

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Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis

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A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis

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Bile acids and their receptors

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The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis

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Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol

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Cross-Talk between Farnesoid-X-Receptor (FXR) and Peroxisome Proliferator-Activated Receptor γ Contributes to the Antifibrotic Activity of FXR Ligands in Rodent Models of Liver Cirrhosis

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Metformin-Induced Glucagon-Like Peptide-1 Secretion Contributes to the Actions of Metformin in Type 2 Diabetes

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Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration

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Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity

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SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis

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Nuclear receptors as therapeutic targets in cholestatic liver diseases

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Mechanisms of disease: inborn errors of bile acid synthesis

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