The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
The relationship between COPD and lung cancer
Open accessAbstract
Both COPD and lung cancer are major worldwide health concerns owing to cigarette smoking, and represent a huge, worldwide, preventable disease burden. Whilst the majority of smokers will not develop either COPD or lung cancer, they are closely related diseases, occurring as co-morbidities at a higher rate than if they were independently triggered by smoking. Lung cancer and COPD may be different aspects of the same disease, with the same underlying predispositions, whether this is an underlying genetic predisposition, telomere shortening, mitochondrial dysfunction or premature aging. In the majority of smokers, the burden of smoking may be dealt with by the body's defense mechanisms: anti-oxidants such as superoxide dismutases, anti-proteases and DNA repair mechanisms. However, in the case of both diseases these fail, leading to cancer if mutations occur or COPD if damage to the cell and proteins becomes too great. Alternatively COPD could be a driving factor in lung cancer, by increasing oxidative stress and the resulting DNA damage, chronic exposure to pro-inflammatory cytokines, repression of the DNA repair mechanisms and increased cellular proliferation. Understanding the mechanisms that drive these processes in primary cells from patients with these diseases along with better disease models is essential for the development of new treatments.
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“Inflammation s a key source of RNOS [33] and RNOS levels are persistently high n COPD.”
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Airway microbiota is associated with upregulation of the PI3K pathway in lung cancer
Tsay, J.-C. J., Wu, B. G., Badri, M. H., Clemente, J. C., Shen, N., Meyn, P., Li, Y., Yie, T.-A., Lhakhang, T., Olsen, E., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201710-2118oc · Cited by 448
Radon Biomonitoring and microRNA in Lung Cancer
Bersimbaev, R., Pulliero, A., Bulgakova, O., Kussainova, A., Aripova, A., & Izzotti, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062154 · Cited by 53
Metadata
- Authors
- Durham, A. L., & Adcock, I. M.
- Venue
- Lung Cancer
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 90
- Issue
- 2
- Pages
- 121-127
- ISSN
- 0169-5002 (ISSN-L)
- OpenAlex
- W1883683241
- Cited by
- 451
- References
- 105
- FWCI
- 18.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
