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Akt/PKB and p38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers

Hsieh, Ching-Chyuan, Papaconstantinou, John·2004·Mechanisms of Ageing and Development
DOI 10.1016/j.mad.2004.07.008
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Abstract

The insulin/IGF-1/GH and p38 MAPK signaling pathways play a key role in the regulation of protein synthesis. The regulation of GH and TSH secretion hormones, that affect the activity of these pathways, plays an important role in the decline of rates of protein synthesis in aged rodent tissues. Studies have indicated that longevity of the Snell dwarf (Pit-1) mouse mutant is associated with the reduction of function of the insulin/IGF-1/GH signaling pathway. We have previously shown that PI3K activity, a signaling protein that plays a key role in the regulation of translation, is also dramatically decreased in the Snell dwarf liver suggesting that the protein synthesis-signaling pathway may be attenuated in this long-lived mouse. Similarly, signaling via p38 MAPK also plays a role in the regulation of protein synthesis. In this study we examined the activities of these signaling pathways to determine if the translation-signaling pathway is altered in young versus aged Snell dwarf mouse livers. Our data indicate that the phosphorylation and kinase activities of Akt/PKB and p38 MAPK, and the levels of phosphorylation of downstream regulators of translation are decreased in dwarf mouse livers. Thus, the overall activities of major components of the translational initiation pathway are decreased in the long-lived Snell dwarf mouse livers. We propose that down-regulation of protein synthesis may be an important characteristic of the Pit-1 mutation and longevity of the Snell dwarf mo…

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Research works printed but not linked: 60

  1. Alessi, 1996, Mechanism of activation of protein kinase B by insulin and IGF-1, EMBO J., 15, 6541, 10.1002/j.1460-2075.1996.tb01045.x · DOI
  2. Alessi, 1998, Mechanism of activation and function of protein kinase B, Curr. Opin. Genet. Dev., 8, 55, 10.1016/S0959-437X(98)80062-2 · DOI
  3. Alessi, 1997, 3-Phosphoinositide-dependent protein kinase-1 (PDK-1): structural and functional homology with the drosophila DSTPK61 kinase, Curr. Biol., 7, 776, 10.1016/S0960-9822(06)00336-8 · DOI
  4. Alessi, 1997, Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha, Curr. Biol., 7, 261, 10.1016/S0960-9822(06)00122-9 · DOI
  5. Balage, 2001, Amino acids and insulin are both required to regulate assembly of the eIF4E–eIF4G complex in rat skeletal muscle, Am. J. Physiol. Endocrinol. Metab., 281, E565, 10.1152/ajpendo.2001.281.3.E565 · DOI
  6. Balendran, 1999, Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylations of p70 S6 kinase in vivo at Thr-412 as well as Thr-252, J. Biol. Chem., 274, 37400, 10.1074/jbc.274.52.37400 · DOI
  7. Bartke, 2003, Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights, Biogerontology, 4, 1, 10.1023/A:1022448532248 · DOI
  8. Bartke, 1998, Does growth hormone prevent or accelerate aging?, Exp. Gerontol., 33, 675, 10.1016/S0531-5565(98)00032-1 · DOI
  9. Bates, 1988, The anabolic effects of growth hormone and thyroxine on protein metabolism in Snell dwarfs and normal mice, J. Endocrinol., 119, 31, 10.1677/joe.0.1190031 · DOI
  10. Bates, 1991, Action and interaction of growth hormone and beta-agonist, clenbuterol, on growth, body composition and protein turnover in dwarf mice, Br. J. Nutr., 65, 115, 10.1079/BJN19910074 · DOI
  11. Brown-Borg, 1996, Dwarf mice and the aging process, Nature, 384, 33, 10.1038/384033a0 · DOI
  12. Bush, 2003, Translational control of protein synthesis in muscle and liver of growth hormone treated pigs, Endocrinology, 144, 1273, 10.1210/en.2002-220983 · DOI
  13. Cohen, 1997, PDK-1, one of the missing links in insulin signal transduction, FEBS Lett., 410, 3, 10.1016/S0014-5793(97)00490-0 · DOI · Paper page
  14. Coshigano, 2002, Assessment of growth parameters and lifespan of GHR/BP gene-disrupted mice, Endocrinology, 144, 3799
  15. Coshigano, 2003, Decreased body weights, insulin, and insulin-like growth factor I levels and increased life-span, Endocrinology, 144, 3799, 10.1210/en.2003-0374 · DOI · Paper page
  16. D’Costa, 1993, The regulation and mechanisms of action of growth hormone and insulin-like growth factor 1 during normal ageing, J. Reprod. Fertil. Suppl., 46, 87
  17. D’Costa, 1993, Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats, Mech. Ageing Dev., 71, 59, 10.1016/0047-6374(93)90035-P · DOI
  18. D’Costa, 1993, Comparison of protein synthesis in brain and peripheral tissue during aging, Ann. N. Y. Acad. Sci., 692, 253, 10.1111/j.1749-6632.1993.tb26225.x · DOI
  19. Dennis, 1999, Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation, Curr. Opin. Genet. Dev., 9, 49, 10.1016/S0959-437X(99)80007-0 · DOI
  20. Dimmeler, 1998, Fluid shear stress stimulates phosphorylations of Akt in human endothelial cells: involvement in suppression of apoptosis, Circ. Res., 83, 334, 10.1161/01.RES.83.3.334 · DOI
  21. Dominici, 2003, The dwarf mutation decreases high dose insulin responses in skeletal muscle, the opposite of effects in liver, Mech. Ageing Dev., 124, 819, 10.1016/S0047-6374(03)00136-2 · DOI
  22. Dorman, 1995, The age-1 and daf-2 genes function as a common pathway to control the lifespan of Caenorhabditis elegans, Genetics, 141, 1399, 10.1093/genetics/141.4.1399 · DOI
  23. Flurkey, 2001, Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production, Proc. Natl. Acad. Sci. U.S.A., 98, 6736, 10.1073/pnas.111158898 · DOI · Paper page
  24. Flurkey, 2002, The Snell dwarf mutation Pitdw can increase lifespan in mice, Mech. Ageing Dev., 123, 121, 10.1016/S0047-6374(01)00339-6 · DOI
  25. Frisch, 1997, Integrins and anoikis, Curr. Opin. Cell Biol., 9, 701, 10.1016/S0955-0674(97)80124-X · DOI
  26. Gingras, 2001, Hierarchical phosphorylations of the translation inhibitor 4E-BP1, Genes Dev., 15, 2852, 10.1101/gad.912401 · DOI · Paper page
  27. Guarante, 2000, Genetic pathways that regulate ageing in model organizations, Nature, 408, 255, 10.1038/35041700 · DOI
  28. Guilherme, 1998, Stimulation of IRS-1 associated phosphatidylinositol 3-kinase and Akt/protein kinase B but not glucose transport by beta-integrin signaling in rat adipocytes, J. Biol. Chem., 273, 33119, 10.1074/jbc.273.50.33119 · DOI
  29. Hara, 1998, Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E-BP1 through a common effector mechanism, J. Biol. Chem., 34, 22160, 10.1016/S0021-9258(18)48898-9 · DOI
  30. Herbert, 2002, The extracellular signal-regulated kinase pathway regulates the phosphorylations of 4E-BP1 at multiple sites, J. Biol. Chem., 277, 11591, 10.1074/jbc.M110367200 · DOI
  31. Hsieh, 2002, Effects of the Pit-1 Mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse, Mech. Ageing Dev., 123, 1245, 10.1016/S0047-6374(02)00037-4 · DOI
  32. Hsieh, 2002, Implications of the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with C. elegans longevity paradigm, Mech. Ageing Dev., 123, 1229, 10.1016/S0047-6374(02)00036-2 · DOI
  33. Hsieh, 2002, The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid, Mech. Ageing Dev., 123, 1423, 10.1016/S0047-6374(02)00084-2 · DOI
  34. Johnson, 1999, Molecular biology of aging, Cell, 96, 291, 10.1016/S0092-8674(00)80567-X · DOI
  35. Kimball, 1999, Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylations of ribosomal protein S6, J. Biol. Chem., 274, 11647, 10.1074/jbc.274.17.11647 · DOI
  36. Kimura, 1997, daf-2, An insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans, Science, 277, 942, 10.1126/science.277.5328.942 · DOI
  37. Lynch, 1999, and Hiles I.D, Oncogene, 18, 8024, 10.1038/sj.onc.1203258 · DOI
  38. Migliaccio, 1999, The pbbshc protein controls oxidative stress response and life span in mammals, Nature, 402, 243, 10.1038/46185 · DOI
  39. Miller, 2002, Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice, Mol. Endocrinol., 16, 2657, 10.1210/me.2002-0142 · DOI
  40. Morris, 1996, A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans, Nature, 382, 536, 10.1038/382536a0 · DOI
  41. Murakami, 2004, Impact of SHIP2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids, Endocrinology, 145, 3215, 10.1210/en.2003-1574 · DOI
  42. Nicholson, 2002, The protein kinase B/Akt signaling pathway in human malignancy, Cell. Signal., 14, 381, 10.1016/S0898-6568(01)00271-6 · DOI
  43. Parks, 1999, Heritable disorders of pituitary development, J. Clin. Endocrinol. Metab., 84, 4362
  44. Partridge, 2002, The evolution of longevity, Curr. Biol., 12, 544, 10.1016/S0960-9822(02)01048-5 · DOI
  45. Pell, 1992, Differential actions of growth hormone and insulin-like growth factor-I on tissue protein metabolism in dwarf mice, Endocrinology, 130, 1942
  46. Proud, 2002, Minireview: regulation of mammalian translation factors by nutrients, Eur. J. Biochem., 269, 5338, 10.1046/j.1432-1033.2002.03292.x · DOI
  47. Raught, 2001, The target of rapamycin (mTOR) proteins, Proc. Natl. Acad. Sci. U.S.A., 98, 7037, 10.1073/pnas.121145898 · DOI
  48. Ryanzanov, 2002, Protein turnover plays a key role in aging, Mech. Ageing Dev., 123, 207, 10.1016/S0047-6374(01)00337-2 · DOI
  49. Ryazanov, 1997, Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase, Proc. Natl. Acad. Sci. U.S.A., 94, 4884, 10.1073/pnas.94.10.4884 · DOI
  50. Sonnenberg, 1998, The mRNA 5′-cap-binding protein eIF4E and control of cell growth, Curr. Opin. Cell Biol., 10, 268, 10.1016/S0955-0674(98)80150-6 · DOI
  51. Sonntag, 1992, Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1, J. Gerontol., 47, 159, 10.1093/geronj/47.5.B159 · DOI
  52. Stephens, 1998, Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B, Science, 279, 710, 10.1126/science.279.5351.710 · DOI
  53. Takano, 2001, Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin, Mol. Cell. Biol., 21, 5050, 10.1128/MCB.21.15.5050-5062.2001 · DOI
  54. Tang, 2001, Amino acid-induced translation of TOP mRNAs is fully dependent of phosphatidylinositol 3-kinase-medited signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation, Mol. Cell. Biol., 21, 8671, 10.1128/MCB.21.24.8671-8683.2001 · DOI
  55. Tatar, 2003, The endocrine regulation of aging by insulin-like signals, Science, 299, 1346, 10.1126/science.1081447 · DOI
  56. Tatar, 2001, AQ mutant drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function, Science, 292, 41, 10.1126/science.1057987 · DOI
  57. Tissenbaum, 1998, An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans, Genetics, 148, 703, 10.1093/genetics/148.2.703 · DOI
  58. Wang, 1998, The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbal esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways, J. Biol. Chem., 273, 9373, 10.1074/jbc.273.16.9373 · DOI
  59. Wang, 2003, The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation, Mol. Cell. Biol., 23, 1546, 10.1128/MCB.23.5.1546-1557.2003 · DOI
  60. Zhu, 2000, Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis, J. Biol. Chem., 275, 2103, 10.1074/jbc.275.3.2103 · DOI

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Metadata

Authors
Hsieh, C.-C., & Papaconstantinou, J.
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
2004-10
Volume
125
Issue
10-11
Pages
785-798
ISSN
0047-6374
DOI
10.1016/j.mad.2004.07.008
Cited by
44
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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