Cited by 204Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA MethylationGenomics and Chromatin Dynamics

Histone methylation makes its mark on longevity

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Han, Shuo, Brunet, Anne·2012·Trends in Cell Biology

Abstract

How long organisms live is not entirely written in their genes. Recent findings reveal that epigenetic factors that regulate histone methylation, a type of chromatin modification, can affect lifespan. The reversible nature of chromatin modifications suggests that therapeutic targeting of chromatin regulators could be used to extend lifespan and healthspan. This review describes the epigenetic regulation of lifespan in diverse model organisms, focusing on the role and mode of action of chromatin regulators that affect two epigenetic marks, trimethylated lysine 4 of histone H3 (H3K4me3) and trimethylated lysine 27 of histone H3 (H3K27me3), in longevity.

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Crossref · 10.1016/j.tcb.2011.11.001

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  • Too much H3K4me3 tracks with an aged epigenome.

    “For example, the ASH-2 trithorax complex mediates trimethylation of histone H3 on Lys4 (H3K4me3), and its deletion increases Caenorhabditis elegans lifespan, consistent with excessive H3K4me3 being associated with an aging epigenome172,173.”

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Authors
Han, S., & Brunet, A.
Affiliations
Stanford University (US)
Corresponding author
Brunet, Anne
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2012-01
Volume
22
Issue
1
Pages
42-49
ISSN
0962-8924 (ISSN-L)
OpenAlex
W1968018974
Cited by
204
References
93
Citations by year
2026: 5 · 2025: 14 · 2024: 5 · 2023: 17 · 2022: 14 · 2021: 13 · 2020: 13 · 2019: 11 · 2018: 20 · 2017: 19 · 2016: 15 · 2015: 18 · 2014: 17 · 2013: 17 · 2012: 6
FWCI
1.34
Type
journal article
Language
en
Open access
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health
  • National Institute on Aging (R01-AG31198, R01AG031198)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
histone methylation, lifespan, longevity, epigenetic regulation, chromatin modification, H3K4me3, H3K27me3, chromatin regulators, healthspan, model organisms
MeSH terms
Animals, Chromatin, Histones, Humans, Longevity, Methylation, Phylogeny, Cellular Senescence

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