Histone methylation makes its mark on longevity
Open accessAbstract
How long organisms live is not entirely written in their genes. Recent findings reveal that epigenetic factors that regulate histone methylation, a type of chromatin modification, can affect lifespan. The reversible nature of chromatin modifications suggests that therapeutic targeting of chromatin regulators could be used to extend lifespan and healthspan. This review describes the epigenetic regulation of lifespan in diverse model organisms, focusing on the role and mode of action of chromatin regulators that affect two epigenetic marks, trimethylated lysine 4 of histone H3 (H3K4me3) and trimethylated lysine 27 of histone H3 (H3K27me3), in longevity.
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Too much H3K4me3 tracks with an aged epigenome.
“For example, the ASH-2 trithorax complex mediates trimethylation of histone H3 on Lys4 (H3K4me3), and its deletion increases Caenorhabditis elegans lifespan, consistent with excessive H3K4me3 being associated with an aging epigenome172,173.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [173]
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- Authors
- Han, S., & Brunet, A.
- Affiliations
- Stanford University (US)
- Corresponding author
- Brunet, Anne
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 22
- Issue
- 1
- Pages
- 42-49
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC3253950
- OpenAlex
- W1968018974
- Cited by
- 204
- References
- 93
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 5 · 2023: 17 · 2022: 14 · 2021: 13 · 2020: 13 · 2019: 11 · 2018: 20 · 2017: 19 · 2016: 15 · 2015: 18 · 2014: 17 · 2013: 17 · 2012: 6
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- National Institute on Aging (R01-AG31198, R01AG031198)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- histone methylation, lifespan, longevity, epigenetic regulation, chromatin modification, H3K4me3, H3K27me3, chromatin regulators, healthspan, model organisms
- MeSH terms
- Animals, Chromatin, Histones, Humans, Longevity, Methylation, Phylogeny, Cellular Senescence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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