The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction
Open accessAbstract
TNF-alpha-mediated apoptosis is enhanced in aged rodent muscles, suggesting that this pathway may be involved in sarcopenia. Interleukin-15 (IL-15), a muscle-derived anabolic cytokine, mitigates muscle wasting and apoptosis in cachectic rats. This effect is thought to occur through inhibition of TNF-alpha-triggered apoptosis. We investigated IL-15 signaling and the TNF-alpha-mediated pathway of apoptosis in the gastrocnemius muscle of Fischer344xBrown Norway rats across the ages of 8, 18, 29 and 37 months, in relation to life-long calorie restriction (CR, 40% calorie intake reduction). Aging caused loss of muscle mass and increased apoptotic DNA fragmentation, which were mitigated by CR. Protein levels of IL-15 and mRNA abundance of IL-15 receptor a-chain decreased in senescent ad libitum (AL) fed rats, but were maintained in CR rodents. Elevations of TNF-alpha, TNF-receptor 1, cleaved caspase-8 and -3 were observed at advanced age in AL rats. These changes were prevented or mitigated by CR. Our results indicate that aging is associated with decreased IL-15 signaling in rat gastrocnemius muscle, which may contribute to sarcopenia partly through enhanced TNF-alpha-mediated apoptosis. Preservation of IL-15 signaling by CR may therefore represent a further mechanism contributing to the anti-aging effect of this dietary intervention in skeletal muscle.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Apoptosis signaling has been reported in muscle and neuronal cells of aged rodents (4, 7, 26, 34, 47, 77, 88, 130), and humans (44, 145).”
From Mitochondria initiate and regulate sarcopenia (2017) · cites this paper as [88]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Bulfone‐Paus, S., Bulanova, E., Pohl, T., Budagian, V., Dürkop, H., Ruckert, R., Kunzendorf, U., Paus, R., & Krause, H. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.12.1575 · Cited by 152
RetractedBulanova, E., Budagian, V., Duitman, E. H., Orinska, Z., Krause, H., Rückert, R., Reiling, N., & Bulfone‐Paus, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610036200 · Cited by 63
RetractedAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950
Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor
Grabstein, K. H., Eisenman, J. R., Shanebeck, K. D., Rauch, C. T., Srinivasan, S., Fung, V., Beers, C., Richardson, J. S., Schoenborn, M. A., Ahdieh, M., et al. (1994) · Science · doi:10.1126/science.8178155 · Cited by 1,422
Visser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., Nevitt, M., & Harris, T. B. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.5.m326 · Cited by 1,294
Carson, W. E., Giri, J. G., Lindemann, M. J., Linett, M. L., Ahdieh, M., Paxton, R. J., Anderson, D. M., Eisenmann, J., Grabstein, K. H., & Caligiuri, M. A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.4.1395 · Cited by 1,094
Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives
Rolland, Y., Czerwinski, S., van Kan, G. A., Morley, J. E., Cesari, M., Onder, G., Woo, J., Baumgartner, R., Pillard, F., Boirie, Y., et al. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982704 · Cited by 1,071
Utilization of the beta and gamma chains of the IL‐2 receptor by the novel cytokine IL‐15.
Giri, J. G., Ahdieh, M., Eisenman, J. R., Shanebeck, K. D., Grabstein, K. H., Kumaki, S., Namen, A. E., Park, L. S., Cosman, D. J., & Anderson, D. M. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06576.x · Cited by 980
Flagged first, then by citations
1 of the 65 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–113 of 113
Rahman, M. S., & Islam, M. R. (2019) · Bangladesh Journal of Neuroscience · doi:10.3329/bjn.v35i1.57624 · Cited by 1
Barry, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00217-x · Cited by 1
Nuclear Apoptosis and Sarcopenia
Alway, S. E., & Siu, P. M. (2010) · Springer eBooks · doi:10.1007/978-90-481-9713-2_9 · Cited by 2
Exercise in the Maintenance of Muscle Mass
Dirks‐Naylor, A. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-397155-5.00020-9
Soares, D. B. D. S. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2020.tde-11062021-125050
(2009) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3283339c93
Pereira, B. C. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2015.tde-31012022-183800
Lan, J., Guo, H., Zou, J., Xue, J., Ni, H., Wang, L., Ren, T., Chai, S., Jiang, H., Gou, C., et al. (2024) · Portal hypertension & cirrhosis · doi:10.1002/poh2.89
Disruption of the Muscle–Brain Axis in Ageing: Role of Myokines in Sarcopenia and Neurodegeneration
Molina, V. A. M., Salinas, C. N. L., Vásquez, C. A., Matos, A., & Riofrío, D. A. (2026) · Cells · doi:10.3390/cells15201910
Hyödynmaa, J. (2015) · Jyväskylä University Digital Archive (University of Jyväskylä)
Metadata
- Authors
- Marzetti, E., Carter, C. S., Wohlgemuth, S. E., Lees, H. A., Giovannini, S., Anderson, B., Quinn, L. S., & Leeuwenburgh, C.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- University of Florida (US)
- University of Washington (US)
- Corresponding author
- Marzetti, Emanuele
- Leeuwenburgh, Christiaan
- ORCID
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 130
- Issue
- 4
- Pages
- 272-280
- ISSN
- 0047-6374 (ISSN-L)
- PMC
- PMC2768529
- OpenAlex
- W1999472449
- Cited by
- 113
- References
- 65
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 7 · 2012: 13
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, other-oa)
- Funders
- National Institute on Aging (R01AG024136, R01AG024526, R01AG017994, AG-21042, R01AG021042, P30AG028740)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- IL-15, caloric restriction, muscle aging, sarcopenia, TNF-α, apoptosis, death receptor signaling, gastrocnemius, skeletal muscle, caspase-8, caspase-3, TNF receptor 1, muscle atrophy, anti-aging diet
- MeSH terms
- Aging, Animals, Body Weight, Male, Organ Size, Tumor Necrosis Factor-alpha, Signal Transduction, Apoptosis, Muscle, Skeletal, Interleukin-15, Caspases, Protein Subunits, Caloric Restriction, Rats, Receptors, Death Domain, Receptors, Interleukin-15
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
